Search Results - "Bahr, Melissa"
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High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis
Published in The Journal of clinical investigation (15-03-2022)“…Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated…”
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Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies
Published in Nature communications (29-12-2022)“…Pretomanid is a nitroimidazole antimicrobial active against drug-resistant Mycobacterium tuberculosis and approved in combination with bedaquiline and…”
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3
Intravenous BCG vaccination reduces SARS-CoV-2 severity and promotes extensive reprogramming of lung immune cells
Published in iScience (20-10-2023)“…Bacillus Calmette-Guérin (BCG) confers heterologous immune protection against viral infections and has been proposed as vaccine against SARS-CoV-2 (SCV2)…”
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4
Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model
Published in mBio (31-08-2021)“…In the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more severe outcomes are…”
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5
Linezolid does not improve bactericidal activity of rifampin-containing first-line regimens in animal models of TB meningitis
Published in International journal of antimicrobial agents (01-01-2024)“…Tuberculous meningitis (TB meningitis) is the most devastating form of tuberculosis (TB) and there is a critical need to optimize treatment. Linezolid is…”
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Visual read of F-18florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease
Published in Alzheimer's & dementia (19-11-2024)“…Patterns of signal from tau positron emission tomography (tau-PET) confined to the medial temporal lobe (MTL) or extended into the neocortex may be relevant…”
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Visual read of [F‐18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease
Published in Alzheimer's & dementia (19-11-2024)“…Abstract INTRODUCTION Patterns of signal from tau positron emission tomography (tau‐PET) confined to the medial temporal lobe (MTL) or extended into the…”
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8
High-dose rifampin improves bactericidal activity without increased intracerebral inflammation in animal models of tuberculous meningitis
Published in The Journal of clinical investigation (01-03-2022)“…Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated…”
Get full text
Journal Article -
9
124I-Iodo-DPA-713 Positron Emission Tomography in a Hamster Model of SARS-CoV-2 Infection
Published in Molecular imaging and biology (01-02-2022)“…Purpose Molecular imaging has provided unparalleled opportunities to monitor disease processes, although tools for evaluating infection remain limited…”
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The SARS-CoV-2 spike protein binds and modulates estrogen receptors
Published in Science advances (02-12-2022)“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein binds angiotensin-converting enzyme 2 as its primary infection mechanism…”
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1411. Noninvasive Assessment of Intralesional Antimicrobial Concentration-Time Profiles in Pulmonary and Central Nervous System Tuberculosis using Dynamic 18F-Pretomanid Positron Emission Tomography
Published in Open forum infectious diseases (04-12-2021)“…Abstract Background Pretomanid is used in combination with bedaquiline and linezolid (BPaL regimen) in the treatment of multidrug-resistant tuberculosis…”
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191. High-Dose Rifampin-containing Regimens for the Treatment of TB Meningitis
Published in Open forum infectious diseases (04-12-2021)“…Abstract Background TB meningitis is the most severe form of tuberculosis (TB), associated with high morbidity and mortality. High-dose rifampin (35mg/kg/day)…”
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Dynamic 18 F-Pretomanid PET imaging in animal models of TB meningitis and human studies
Published in Nature communications (29-12-2022)“…Pretomanid is a nitroimidazole antimicrobial active against drug-resistant Mycobacterium tuberculosis and approved in combination with bedaquiline and…”
Get full text
Journal Article -
14
124 I-Iodo-DPA-713 Positron Emission Tomography in a Hamster Model of SARS-CoV-2 Infection
Published in Molecular imaging and biology (01-02-2022)“…Molecular imaging has provided unparalleled opportunities to monitor disease processes, although tools for evaluating infection remain limited. Coronavirus…”
Get full text
Journal Article