Search Results - "Bahr, Ben A"

Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways by Farizatto, Karen L G, Ikonne, Uzoma S, Almeida, Michael F, Ferrari, Merari F R, Bahr, Ben A

“…Impaired protein clearance likely increases the risk of protein accumulation disorders including Alzheimer's disease (AD). Protein degradation through the…”
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The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer's Disease and Parkinson's Disease and Models of Mild Cognitive Impairment by Hwang, Jeannie, Estick, Candice M, Ikonne, Uzoma S, Butler, David, Pait, Morgan C, Elliott, Lyndsie H, Ruiz, Sarah, Smith, Kaitlan, Rentschler, Katherine M, Mundell, Cary, Almeida, Michael F, Stumbling Bear, Nicole, Locklear, James P, Abumohsen, Yara, Ivey, Cecily M, Farizatto, Karen L G, Bahr, Ben A

“…Many neurodegenerative disorders have lysosomal impediments, and the list of proposed treatments targeting lysosomes is growing. We investigated the role of…”
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Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models by Butler, David, Hwang, Jeannie, Estick, Candice, Nishiyama, Akiko, Kumar, Saranya Santhosh, Baveghems, Clive, Young-Oxendine, Hollie B, Wisniewski, Meagan L, Charalambides, Ana, Bahr, Ben A

“…Alzheimer's disease (AD) is an age-related neurodegenerative pathology in which defects in proteolytic clearance of amyloid β peptide (Aβ) likely contribute to…”
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Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: A neuroprotective therapeutic modality by Hwang, Jeannie, Adamson, Crista, Butler, David, Janero, David R., Makriyannis, Alexandros, Bahr, Ben A.

“…This review posits that fatty acid amide hydrolase (FAAH) inhibition has therapeutic potential against neuropathological states including traumatic brain…”
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The neuropathogenic contributions of lysosomal dysfunction by Bahr, Ben A., Bendiske, Jennifer

“…Multiple lines of evidence implicate lysosomes in a variety of pathogenic events that produce neurodegeneration. Genetic mutations that cause specific enzyme…”
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Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage by Karanian, David A, Karim, Sanjida L, Wood, JodiAnne T, Williams, John S, Lin, Sonyuan, Makriyannis, Alexandros, Bahr, Ben A

“…Endocannabinoids are released in response to pathogenic insults, and inhibitors of endocannabinoid inactivation enhance such on-demand responses that promote…”
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Dual Modulation of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Protects against Excitotoxicity by Karanian, David A, Brown, Queenie B, Makriyannis, Alexandros, Kosten, Therese A, Bahr, Ben A

“…The endocannabinoid system has been suggested to elicit signals that defend against several disease states including excitotoxic brain damage. Besides direct…”
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Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases by Wang, Chao, Telpoukhovskaia, Maria A, Bahr, Ben A, Chen, Xu, Gan, Li

“…•Multiple genes for AD, PD and FTD are involved in the endo-lysosomal pathways.•Dysfunction of endo-lysosomal pathways impairs degradation of pathogenic…”
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Two pools of Triton X‐100‐insoluble GABAA receptors are present in the brain, one associated to lipid rafts and another one to the post‐synaptic GABAergic complex by Li, Xuejing, Serwanski, David R., Miralles, Celia P., Bahr, Ben A., De Blas, Angel L.

“…Rat forebrain synaptosomes were extracted with Triton X‐100 at 4°C and the insoluble material, which is enriched in post‐synaptic densities (PSDs), was…”
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Distinct ginseng extracts produce disparate effects on proteostatic support through the autophagy‐lysosomal pathway that is linked to synaptic resilience and cognitive health by Almeida, Michael F., Strangman, Wendy, Bahr, Ben A.

“…The growing incidence of age‐related proteinopathies like Alzheimer’s disease (AD) warrants high‐level understanding of protein quality control pathways and…”
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The critical role of calpain versus caspase activation in excitotoxic injury induced by nitric oxide by Volbracht, Christiane, Chua, Boon Tin, Ng, Chee Peng, Bahr, Ben A., Hong, Wanjin, Li, Peng

“…The pathogenesis of various acute and chronic neurodegenerative disorders has been linked to excitotoxic processes and excess generation of nitric oxide. We…”
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Cleavage of the vesicular glutamate transporters under excitotoxic conditions by Lobo, Andrea C, Gomes, João R, Catarino, Tatiana, Mele, Miranda, Fernandez, Pedro, Inácio, Ana R, Bahr, Ben A, Santos, Armanda E, Wieloch, Tadeusz, Carvalho, Ana Luísa, Duarte, Carlos B

“…Abstract Glutamate is loaded into synaptic vesicles by vesicular glutamate transporters (VGLUTs), and alterations in the transporters expression directly…”
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Calpain activation is involved in early caspase-independent neurodegeneration in the hippocampus following status epilepticus by Araújo, Inês M, Gil, Joana M, Carreira, Bruno P, Mohapel, Paul, Petersen, Åsa, Pinheiro, Paulo S, Soulet, Denis, Bahr, Ben A, Brundin, Patrik, Carvalho, Caetana M

“…Evidence for increased calpain activity has been described in the hippocampus of rodent models of temporal lobe epilepsy. However, it is not known whether…”
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The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states by Vanderklish, Peter W., Bahr, Ben A.

“…Over‐activation of calpain, a ubiquitous calcium‐sensitive protease, has been linked to a variety of degenerative conditions in the brain and several other…”
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Stimulation of autophagy and synaptic maintenance are commonalities induced by an exercise‐mimetic and diet supplement to avoid initiators of age‐related cognitive decline by Almeida, Michael F., Kinsey, Stephen A., Bahr, Ben A.

“…Brain aging causes synaptic and cellular vulnerabilities, leading to cognitive impairment and an increased risk for dementia. Removal of old and damaged…”
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Protein kinase C is a common component of CGRP receptor desensitization induced by distinct agonists by Pin, Sokhom S., Bahr, Ben A.

“…The calcitonin gene-related peptide (CGRP) is a neuropeptide involved in vasodilation and other physiological functions throughout the body. The receptor for…”
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Role of the proteasome in excitotoxicity-induced cleavage of glutamic acid decarboxylase in cultured hippocampal neurons by Baptista, Márcio S, Melo, Carlos V, Armelão, Mário, Herrmann, Dennis, Pimentel, Diogo O, Leal, Graciano, Caldeira, Margarida V, Bahr, Ben A, Bengtson, Mário, Almeida, Ramiro D, Duarte, Carlos B

“…Glutamic acid decarboxylase is responsible for synthesizing GABA, the major inhibitory neurotransmitter, and exists in two isoforms--GAD65 and GAD67. The…”
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Nuclear translocation and calpain-dependent reduction of Bcl-2 after neonatal cerebral hypoxia–ischemia by Zhu, Changlian, Hallin, Ulrika, Ozaki, Yasuhiko, Grandér, Rita, Gatzinsky, Kliment, Bahr, Ben A, Karlsson, Jan-Olof, Shibasaki, Futoshi, Hagberg, Henrik, Blomgren, Klas

“…Abstract Apoptosis-related mechanisms are important in the pathophysiology of hypoxic–ischemic injury in the neonatal brain. Caspases are the major…”
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Ampakine CX516 ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation by Kanju, Patrick M., Parameshwaran, Kodeeswaran, Sims, Catrina, Bahr, Ben A., Shonesy, Brian C., Suppiramaniam, Vishnu

“…AMPAkines are positive modulators of AMPA receptors, and previous work has shown that these compounds can facilitate synaptic plasticity and improve learning…”
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Lifestyle strategies to promote proteostasis and reduce the risk of Alzheimer's disease and other proteinopathies by Almeida, Michael F, Farizatto, Karen L G, Almeida, Renato S, Bahr, Ben A

“…Unhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition, gradually increasing the risk for mild cognitive impairment (MCI)…”
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