Search Results - "Bahney, Chelsea S"

Cellular biology of fracture healing by Bahney, Chelsea S., Zondervan, Robert L., Allison, Patrick, Theologis, Alekos, Ashley, Jason W., Ahn, Jaimo, Miclau, Theodore, Marcucio, Ralph S., Hankenson, Kurt D.

“…ABSTRACT The biology of bone healing is a rapidly developing science. Advances in transgenic and gene‐targeted mice have enabled tissue and cell‐specific…”
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Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes by Hu, Diane P, Ferro, Federico, Yang, Frank, Taylor, Aaron J, Chang, Wenhan, Miclau, Theodore, Marcucio, Ralph S, Bahney, Chelsea S

“…Fractures heal predominantly through the process of endochondral ossification. The classic model of endochondral ossification holds that chondrocytes mature to…”
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Stem Cell–Derived Endochondral Cartilage Stimulates Bone Healing by Tissue Transformation by Bahney, Chelsea S, Hu, Diane P, Taylor, Aaron J, Ferro, Federico, Britz, Hayley M, Hallgrimsson, Benedikt, Johnstone, Brian, Miclau, Theodore, Marcucio, Ralph S

“…ABSTRACT Although bone has great capacity for repair, there are a number of clinical situations (fracture non‐unions, spinal fusions, revision arthroplasty,…”
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Smart bone plates can monitor fracture healing by Lin, Monica C., Hu, Diane, Marmor, Meir, Herfat, Safa T., Bahney, Chelsea S., Maharbiz, Michel M.

“…There are currently no standardized methods for assessing fracture healing, with physicians relying on X-rays which are only useful at later stages of repair…”
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Local injections of β-NGF accelerates endochondral fracture repair by promoting cartilage to bone conversion by Rivera, Kevin O., Russo, Fabrizio, Boileau, Ryan M., Tomlinson, Ryan E., Miclau, Theodore, Marcucio, Ralph S., Desai, Tejal A., Bahney, Chelsea S.

“…There are currently no pharmacological approaches in fracture healing designed to therapeutically stimulate endochondral ossification. In this study, we test…”
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Origin of Reparative Stem Cells in Fracture Healing by Bragdon, Beth C., Bahney, Chelsea S.

“…Purpose of Review The identity and functional roles of stem cell population(s) that contribute to fracture repair remains unclear. This review provides a brief…”
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Growth factor delivery using extracellular matrix-mimicking substrates for musculoskeletal tissue engineering and repair by Gresham, Robert C.H., Bahney, Chelsea S., Leach, J. Kent

“…Therapeutic approaches for musculoskeletal tissue regeneration commonly employ growth factors (GFs) to influence neighboring cells and promote migration,…”
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The multifaceted role of the vasculature in endochondral fracture repair by Bahney, Chelsea S, Hu, Diane P, Miclau, 3rd, Theodore, Marcucio, Ralph S

“…Fracture healing is critically dependent upon an adequate vascular supply. The normal rate for fracture delayed or non-union is estimated to be between 10 and…”
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Wireless Measurements Using Electrical Impedance Spectroscopy to Monitor Fracture Healing by Fukase, Naomasa, Duke, Victoria R, Lin, Monica C, Stake, Ingrid K, Huard, Matthieu, Huard, Johnny, Marmor, Meir T, Maharbiz, Michel M, Ehrhart, Nicole P, Bahney, Chelsea S, Herfat, Safa T

“…There is an unmet need for improved, clinically relevant methods to longitudinally quantify bone healing during fracture care. Here we develop a smart bone…”
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Encapsulation of β-NGF in injectable microrods for localized delivery accelerates endochondral fracture repair by Rivera, Kevin O, Cuylear, Darnell L, Duke, Victoria R, O'Hara, Kelsey M, Zhong, Justin X, Elghazali, Nafisa A, Finbloom, Joel A, Kharbikar, Bhushan N, Kryger, Alex N, Miclau, Theodore, Marcucio, Ralph S, Bahney, Chelsea S, Desai, Tejal A

“…Currently, there are no non-surgical FDA-approved biological approaches to accelerate fracture repair. Injectable therapies designed to stimulate bone healing…”
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Preclinical models of orthopaedic trauma: Orthopaedic Research Society (ORS) and Orthopaedic Trauma Association (OTA) symposium 2022 by Wise, Patrick M, Saiz, Augustine M, Haller, Justin, Wenke, Joseph C, Schaer, Thomas, Schneider, Prism, Morshed, Saam, Bahney, Chelsea S

“…Orthopaedic trauma remains a leading cause of patient morbidity, mortality, and global health care burden. Although significant advances have been made in the…”
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Bone turnover markers as surrogates of fracture healing after intramedullary fixation of tibia and femur fractures by Stewart, Christopher C, O'Hara, Nathan N, Bzovsky, Sofia, Bahney, Chelsea S, Sprague, Sheila, Slobogean, Gerard P

“…Bone turnover markers (BTMs) follow distinct trends after fractures and limited evidence suggests differential levels in BTMs in patients with delayed healing…”
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Sustained-release losartan from peptide nanofibers promotes chondrogenesis by Yamaura, Kohei, Sather, Nicholas A, Metlushko, Anna, Nishimura, Haruki, Pavlović, Radoslav Z, Hambright, Sealy, Ravuri, Sudheer K, Philippon, Marc J, Stupp, Samuel I, Bahney, Chelsea S, Huard, Johnny

“…The central pathologic feature of osteoarthritis (OA) is the progressive loss of articular cartilage, which has a limited regenerative capacity. The TGF-β1…”
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Promoting Endochondral Bone Repair Using Human Osteoarthritic Articular Chondrocytes by Bahney, Chelsea S, Jacobs, Linsey, Tamai, Robert, Hu, Diane, Luan, Tammy F, Wang, Miqi, Reddy, Sanjay, Park, Michelle, Limburg, Sonja, Kim, Hubert T, Marcucio, Ralph, Kuo, Alfred C

“…Current tissue engineering strategies to heal critical-size bone defects through direct bone formation are limited by incomplete integration of grafts with…”
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Microenvironmental Regulation of Chondrocyte Plasticity in Endochondral Repair-A New Frontier for Developmental Engineering by Wong, Sarah A, Rivera, Kevin O, Miclau, 3rd, Theodore, Alsberg, Eben, Marcucio, Ralph S, Bahney, Chelsea S

“…The majority of fractures heal through the process of endochondral ossification, in which a cartilage intermediate forms between the fractured bone ends and is…”
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A bioresponsive hydrogel tuned to chondrogenesis of human mesenchymal stem cells by Bahney, Chelsea S., Hsu, Chih-Wei, Yoo, Jung U., West, Jennifer L., Johnstone, Brian

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Stimulating Fracture Healing in Ischemic Environments: Does Oxygen Direct Stem Cell Fate during Fracture Healing? by Miclau, Katherine R, Brazina, Sloane A, Bahney, Chelsea S, Hankenson, Kurt D, Hunt, Thomas K, Marcucio, Ralph S, Miclau, Theodore

“…Bone fractures represent an enormous societal and economic burden as one of the most prevalent causes of disability worldwide. Each year, nearly 15 million…”
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Cellular expansion of MSCs: Shifting the regenerative potential by Miclau, Katherine, Hambright, William S., Huard, Johnny, Stoddart, Martin J., Bahney, Chelsea S.

“…Mesenchymal‐derived stromal or progenitor cells, commonly called “MSCs,” have attracted significant clinical interest for their remarkable abilities to promote…”
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Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling by Haffner-Luntzer, Melanie, Foertsch, Sandra, Fischer, Verena, Prystaz, Katja, Tschaffon, Miriam, Mödinger, Yvonne, Bahney, Chelsea S., Marcucio, Ralph S., Miclau, Theodore, Ignatius, Anita, Reber, Stefan O.

“…Chronic psychosocial stress/trauma represents an increasing burden in our modern society and a risk factor for the development of mental disorders, including…”
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Mechanical strain drives exosome production, function, and miRNA cargo in C2C12 muscle progenitor cells by Mullen, Michael, Williams, Katherine, LaRocca, Tom, Duke, Victoria, Hambright, William S., Ravuri, Sudheer K., Bahney, Chelsea S., Ehrhart, Nicole, Huard, Johnny

“…Mesenchymal stem cells (MSCs) have been proven to promote tissue repair. However, concerns related to their clinical application and regulatory hurdles remain…”
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