Search Results - "Bahna, Fabiana"

Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class by Rapp, Micah, Guo, Yicheng, Reddem, Eswar R., Yu, Jian, Liu, Lihong, Wang, Pengfei, Cerutti, Gabriele, Katsamba, Phinikoula, Bimela, Jude S., Bahna, Fabiana A., Mannepalli, Seetha M., Zhang, Baoshan, Kwong, Peter D., Huang, Yaoxing, Ho, David D., Shapiro, Lawrence, Sheng, Zizhang

“…Antibodies with heavy chains that derive from the VH1-2 gene constitute some of the most potent severe acute respiratory syndrome coronavirus 2…”
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Visualization of clustered protocadherin neuronal self-recognition complexes by Brasch, Julia, Goodman, Kerry M., Noble, Alex J., Rapp, Micah, Mannepalli, Seetha, Bahna, Fabiana, Dandey, Venkata P., Bepler, Tristan, Berger, Bonnie, Maniatis, Tom, Potter, Clinton S., Carragher, Bridget, Honig, Barry, Shapiro, Lawrence

“…Neurite self-recognition and avoidance are fundamental properties of all nervous systems 1 . These processes facilitate dendritic arborization 2 , 3 , prevent…”
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Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions by Rubinstein, Rotem, Thu, Chan Aye, Goodman, Kerry Marie, Wolcott, Holly Noelle, Bahna, Fabiana, Mannepalli, Seetha, Ahlsen, Goran, Chevee, Maxime, Halim, Adnan, Clausen, Henrik, Maniatis, Tom, Shapiro, Lawrence, Honig, Barry

“…Self-avoidance, a process preventing interactions of axons and dendrites from the same neuron during development, is mediated in vertebrates through the…”
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How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition by Goodman, Kerry Marie, Katsamba, Phinikoula S, Rubinstein, Rotem, Ahlsén, Göran, Bahna, Fabiana, Mannepalli, Seetha, Dan, Hanbin, Sampogna, Rosemary V, Shapiro, Lawrence, Honig, Barry

“…The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms provides diverse identities to individual vertebrate neurons and a…”
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The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins by Harrison, Oliver J., Jin, Xiangshu, Hong, Soonjin, Bahna, Fabiana, Ahlsen, Goran, Brasch, Julia, Wu, Yinghao, Vendome, Jeremie, Felsovalyi, Klara, Hampton, Cheri M., Troyanovsky, Regina B., Ben-Shaul, Avinoam, Frank, Joachim, Troyanovsky, Sergey M., Shapiro, Lawrence, Honig, Barry

“…Adherens junctions, which play a central role in intercellular adhesion, comprise clusters of type I classical cadherins that bind via extracellular domains…”
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Neutralizing antibody 5-7 defines a distinct site of vulnerability in SARS-CoV-2 spike N-terminal domain by Cerutti, Gabriele, Guo, Yicheng, Wang, Pengfei, Nair, Manoj S., Wang, Maple, Huang, Yaoxing, Yu, Jian, Liu, Lihong, Katsamba, Phinikoula S., Bahna, Fabiana, Reddem, Eswar R., Kwong, Peter D., Ho, David D., Sheng, Zizhang, Shapiro, Lawrence

“…Antibodies that potently neutralize SARS-CoV-2 target mainly the receptor-binding domain or the N-terminal domain (NTD). Over a dozen potently neutralizing…”
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Robust Prediction of Relative Binding Energies for Protein–Protein Complex Mutations Using Free Energy Perturbation Calculations by Sampson, Jared M., Cannon, Daniel A., Duan, Jianxin, Epstein, Jordan C.K., Sergeeva, Alina P., Katsamba, Phinikoula S., Mannepalli, Seetha M., Bahna, Fabiana A., Adihou, Hélène, Guéret, Stéphanie M., Gopalakrishnan, Ranganath, Geschwindner, Stefan, Rees, D. Gareth, Sigurdardottir, Anna, Wilkinson, Trevor, Dodd, Roger B., De Maria, Leonardo, Mobarec, Juan Carlos, Shapiro, Lawrence, Honig, Barry, Buchanan, Andrew, Friesner, Richard A., Wang, Lingle

“…[Display omitted] •Reliable calculation of relative binding free energy changes for most protein mutations to within ∼1 kcal/mol.•Automated Protein FEP+ Groups…”
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γ-Protocadherin structural diversity and functional implications by Goodman, Kerry Marie, Rubinstein, Rotem, Thu, Chan Aye, Mannepalli, Seetha, Bahna, Fabiana, Ahlsén, Göran, Rittenhouse, Chelsea, Maniatis, Tom, Honig, Barry, Shapiro, Lawrence

“…Stochastic cell-surface expression of α-, β-, and γ-clustered protocadherins (Pcdhs) provides vertebrate neurons with single-cell identities that underlie…”
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Structural and energetic determinants of adhesive binding specificity in type I cadherins by Vendome, Jeremie, Felsovalyi, Klara, Song, Hang, Yang, Zhongyu, Jin, Xiangshu, Brasch, Julia, Harrison, Oliver J., Ahlsen, Goran, Bahna, Fabiana, Kaczynska, Anna, Katsamba, Phinikoula S., Edmond, Darwin, Hubbell, Wayne L., Shapiro, Lawrence, Honig, Barry

“…Type I cadherin cell-adhesion proteins are similar in sequence and structure and yet are different enough to mediate highly specific cell-cell recognition…”
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Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules by Xu, Shuwa, Sergeeva, Alina P., Katsamba, Phinikoula S., Mannepalli, Seetha, Bahna, Fabiana, Bimela, Jude, Zipursky, S. Lawrence, Shapiro, Lawrence, Honig, Barry, Zinn, Kai

“…Neurons in the developing brain express many different cell adhesion molecules (CAMs) on their surfaces. CAM-binding affinities can vary by more than 200-fold,…”
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Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function by Blockus, Heike, Rolotti, Sebi V., Szoboszlay, Miklos, Peze-Heidsieck, Eugénie, Ming, Tiffany, Schroeder, Anna, Apostolo, Nuno, Vennekens, Kristel M., Katsamba, Phinikoula S., Bahna, Fabiana, Mannepalli, Seetha, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence, de Wit, Joris, Losonczy, Attila, Polleux, Franck

“…Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and subcellular specificity. We report that the axon guidance receptor…”
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Mechanism of E-cadherin dimerization probed by NMR relaxation dispersion by Li, Ying, Altorelli, Nicole L., Bahna, Fabiana, Honig, Barry, Shapiro, Lawrence, Palmer, Arthur G.

“…Epithelial cadherin (E-cadherin), a member of the classical cadherin family, mediates calcium-dependent homophilic cell–cell adhesion. Crystal structures of…”
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Lipocalin-2 is an anorexigenic signal in primates by Petropoulou, Peristera-Ioanna, Mosialou, Ioanna, Shikhel, Steven, Hao, Lihong, Panitsas, Konstantinos, Bisikirska, Brygida, Luo, Na, Bahna, Fabiana, Kim, Jongho, Carberry, Patrick, Zanderigo, Francesca, Simpson, Norman, Bakalian, Mihran, Kassir, Suham, Shapiro, Lawrence, Underwood, Mark D, May, Christina M, Soligapuram Sai, Kiran Kumar, Jorgensen, Matthew J, Confavreux, Cyrille B, Shapses, Sue, Laferrère, Blandine, Mintz, Akiva, Mann, J John, Rubin, Mishaela, Kousteni, Stavroula

“…In the mouse, the osteoblast-derived hormone Lipocalin-2 (LCN2) suppresses food intake and acts as a satiety signal. We show here that meal challenges increase…”
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Type II Cadherin Ectodomain Structures: Implications for Classical Cadherin Specificity by Patel, Saurabh D., Ciatto, Carlo, Chen, Chien Peter, Bahna, Fabiana, Rajebhosale, Manisha, Arkus, Natalie, Schieren, Ira, Jessell, Thomas M., Honig, Barry, Price, Stephen R., Shapiro, Lawrence

“…Type I and II classical cadherins help to determine the adhesive specificities of animal cells. Crystal-structure determination of ectodomain regions from…”
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Crystal structures of Drosophila N-cadherin ectodomain regions reveal a widely used class of Ca2+-free interdomain linkers by Jin, Xiangshu, Walker, Melissa A, Felsövályi, Klára, Vendome, Jeremie, Bahna, Fabiana, Mannepalli, Seetha, Cosmanescu, Filip, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence

“…Vertebrate classical cadherins mediate selective calcium-dependent cell adhesion by mechanisms now understood at the atomic level. However, structures and…”
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Dynamic Properties of a Type II Cadherin Adhesive Domain: Implications for the Mechanism of Strand-Swapping of Classical Cadherins by Miloushev, Vesselin Z., Bahna, Fabiana, Ciatto, Carlo, Ahlsen, Goran, Honig, Barry, Shapiro, Lawrence, Palmer, Arthur G.

“…Cadherin-mediated cell adhesion is achieved through dimerization of cadherin N-terminal extracellular (EC1) domains presented from apposed cells. The dimer…”
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Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite by Cerutti, Gabriele, Guo, Yicheng, Zhou, Tongqing, Gorman, Jason, Lee, Myungjin, Rapp, Micah, Reddem, Eswar R., Yu, Jian, Bahna, Fabiana, Bimela, Jude, Huang, Yaoxing, Katsamba, Phinikoula S., Liu, Lihong, Nair, Manoj S., Rawi, Reda, Olia, Adam S., Wang, Pengfei, Zhang, Baoshan, Chuang, Gwo-Yu, Ho, David D., Sheng, Zizhang, Kwong, Peter D., Shapiro, Lawrence

“…Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally target either the receptor-binding domain (RBD) or the N-terminal…”
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Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies by Cerutti, Gabriele, Rapp, Micah, Guo, Yicheng, Bahna, Fabiana, Bimela, Jude, Reddem, Eswar R., Yu, Jian, Wang, Pengfei, Liu, Lihong, Huang, Yaoxing, Ho, David D., Kwong, Peter D., Sheng, Zizhang, Shapiro, Lawrence

“…Emerging SARS-CoV-2 strains, B.1.1.7 and B.1.351, from the UK and South Africa, respectively, show decreased neutralization by monoclonal antibodies and…”
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Free Energy Perturbation Calculations of Mutation Effects on SARS-CoV-2 RBD::ACE2 Binding Affinity by Sergeeva, Alina P., Katsamba, Phinikoula S., Liao, Junzhuo, Sampson, Jared M., Bahna, Fabiana, Mannepalli, Seetha, Morano, Nicholas C., Shapiro, Lawrence, Friesner, Richard A., Honig, Barry

“…[Display omitted] •Effects of mutations on RBD::ACE2 binding are calculated and tested experimentally.•Free energy perturbation (FEP) produces the most…”
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Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins by Goodman, Kerry Marie, Rubinstein, Rotem, Thu, Chan Aye, Bahna, Fabiana, Mannepalli, Seetha, Ahlsén, Göran, Rittenhouse, Chelsea, Maniatis, Tom, Honig, Barry, Shapiro, Lawrence

“…Clustered protocadherin proteins (α-, β-, and γ-Pcdhs) provide a high level of cell-surface diversity to individual vertebrate neurons, engaging in highly…”
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