Search Results - "Bahirvani, Avinash Govind"
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Highly efficient Runx1 enhancer eR1-mediated genetic engineering for fetal, child and adult hematopoietic stem cells
Published in Gene (30-01-2023)“…•eR1-CreERT2 Tg mice useful for HSC-specific genetic engineering are generated.•Highly efficient gene targeting in fetal, child and adult HSC is achievable.•No…”
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Activation of EVI1 transcription by the LEF1/β-catenin complex with p53-alteration in myeloid blast crisis of chronic myeloid leukemia
Published in Biochemical and biophysical research communications (22-01-2017)“…The presence of a BCR-ABL1 fusion gene is necessary for the pathogenesis of chronic myeloid leukemia (CML) through t(9;22)(q34;q11) translocation. Imatinib, an…”
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Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines
Published in Gene (30-03-2021)“…•Pharmacological inhibition on seR3s suppresses EBV-positive B cell proliferation.•CRISPR/Cas9-medicated excision of seR3s reduces propagation of the…”
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Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia
Published in Experimental hematology (01-09-2024)“…•NOTCH pathway genes are frequently mutated in acute megakaryoblastic leukemia (AMKL).•Pharmacological NOTCH activation suppresses AMKL cell…”
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