Search Results - "Bahia, Parmvir K"

The exceptionally high reactivity of Cys 621 is critical for electrophilic activation of the sensory nerve ion channel TRPA1 by Bahia, Parmvir K, Parks, Thomas A, Stanford, Katherine R, Mitchell, David A, Varma, Sameer, Stevens, Jr, Stanley M, Taylor-Clark, Thomas E

“…Activation of the sensory nerve ion channel TRPA1 by electrophiles is the key mechanism that initiates nociceptive signaling, and leads to defensive reflexes…”
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Differential sensitivity of cinnamaldehyde-evoked calcium fluxes to ruthenium red in guinea pig and mouse trigeminal sensory neurons by Bahia, Parmvir K, Taylor-Clark, Thomas E

“…Transient receptor potential ankyrin 1 (TRPA1) is an excitatory ion channel expressed on a subset of sensory neurons. TRPA1 is activated by a host of noxious…”
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Sensory nerve terminal mitochondrial dysfunction activates airway sensory nerves via transient receptor potential (TRP) channels by Nesuashvili, Lika, Hadley, Stephen H, Bahia, Parmvir K, Taylor-Clark, Thomas E

“…Mitochondrial dysfunction and subsequent oxidative stress has been reported for a variety of cell types in inflammatory diseases. Given the abundance of…”
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Dietary flavonoid (−)epicatechin stimulates phosphatidylinositol 3‐kinase‐dependent anti‐oxidant response element activity and up‐regulates glutathione in cortical astrocytes by Bahia, Parmvir K., Rattray, Marcus, Williams, Robert J.

“…Flavonoids are plant‐derived polyphenolic compounds with neuroprotective properties. Recent work suggests that, in addition to acting as hydrogen donors, they…”
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Thy1.2 YFP-16 transgenic mouse labels a subset of large-diameter sensory neurons that lack TRPV1 expression by Taylor-Clark, Thomas E, Wu, Kevin Y, Thompson, Julie-Ann, Yang, Kiseok, Bahia, Parmvir K, Ajmo, Joanne M

“…The Thy1.2 YFP-16 mouse expresses yellow fluorescent protein (YFP) in specific subsets of peripheral and central neurons. The original characterization of this…”
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Functional evidence of distinct electrophile-induced activation states of the ion channel TRPA1 by Parks, Thomas A., Bahia, Parmvir K., Taylor-Clark, Thomas E.

“…Transient Receptor Potential Ankyrin 1 (TRPA1) is a tetrameric, nonselective cation channel expressed on nociceptive sensory nerves whose activation elicits…”
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Improving redox sensitivity of roGFP1 by incorporation of selenocysteine at position 147 by Stanford, Katherine R, Ajmo, Joanne M, Bahia, Parmvir K, Hadley, Stephen H, Taylor-Clark, Thomas E

“…Redox-sensitive green fluorescent protein (roGFP) is a genetically-encoded redox-sensitive protein used to detect cellular oxidative stress associated with…”
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Reductions in external divalent cations evoke novel voltage-gated currents in sensory neurons by Bahia, Parmvir K, Bennett, Eric S, Taylor-Clark, Thomas E

“…It has long been recognized that divalent cations modulate cell excitability. Sensory nerve excitability is of critical importance to peripheral diseases…”
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Small conductance Ca2+-activated K+ channels formed by the expression of rat SK1 and SK2 genes in HEK 293 cells by Benton, David C. H., Monaghan, Alan S., Hosseini, Ramine, Bahia, Parmvir K., Haylett, Dennis G., Moss, Guy W. J.

“…The rat SK1 gene ( rSK1 ) does not form functional Ca 2+ -activated potassium channels when expressed alone in mammalian cell lines. Using a selective antibody…”
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The SK3 Subunit of Small Conductance Ca2+-activated K+ Channels Interacts with Both SK1 and SK2 Subunits in a Heterologous Expression System by Monaghan, Alan S., Benton, David C.H., Bahia, Parmvir K., Hosseini, Ramine, Shah, Yousaf A., Haylett, Dennis G., Moss, Guy W.J.

“…The aim of this study was to determine whether functional heteromeric channels can be formed by co-assembly of rat SK3 (rSK3) potassium channel subunits with…”
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SPARC: Development of a TRPA1 Reporter Mouse Model by Bahia, Parmvir K., Patil, Mayur, Kim, Seol‐Hee, Harsányiová, Jana, Kollarik, Marian, Taylor‐Clark, Thomas

“…Transient receptor potential ankyrin 1 (TRPA1) is a cation channel activated by electrophilic irritants and oxidative stress. It is expressed in nociceptive…”
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Antimycin A-induced mitochondrial dysfunction activates vagal sensory neurons via ROS-dependent activation of TRPA1 and ROS-independent activation of TRPV1 by Stanford, Katherine R., Hadley, Stephen H., Barannikov, Ivan, Ajmo, Joanne M., Bahia, Parmvir K., Taylor-Clark, Thomas E.

“…•Antimycin A-induced mitochondrial dysfunction activates a subset of vagal nociceptors.•Antimycin A-evoked Ca2+ fluxes correlate with capsaicin (TRPV1)…”
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Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity by Bahia, Parmvir K., Pugh, Victoria, Hoyland, Kimberley, Hensley, Victoria, Rattray, Marcus, Williams, Robert J.

“…The Forkhead transcription factor, FoxO3a induces genomic death responses in neurones following translocation from the cytosol to the nucleus. Nuclear…”
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Sensory nerve terminal mitochondrial dysfunction induces hyperexcitability in airway nociceptors via protein kinase C by Hadley, Stephen H, Bahia, Parmvir K, Taylor-Clark, Thomas E

“…Airway sensory nerve excitability is a key determinant of respiratory disease-associated reflexes and sensations such as cough and dyspnea. Inflammatory…”
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Antimycin A increases bronchopulmonary C-fiber excitability via protein kinase C alpha by Bahia, Parmvir K, Hadley, Stephen H, Barannikov, Ivan, Sowells, Isobel, Kim, Seol-Hee, Taylor-Clark, Thomas E

“…•Vagal sensory neurons express multiple PKC isoforms.•Antimycin causes translocation of only PKCα, only in TRPV1-lineage vagal neurons.•Antimycin causes…”
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Mapping of the Sensory Innervation of the Mouse Lung by Specific Vagal and Dorsal Root Ganglion Neuronal Subsets by Kim, Seol-Hee, Patil, Mayur J, Hadley, Stephen H, Bahia, Parmvir K, Butler, Shane G, Madaram, Meghana, Taylor-Clark, Thomas E

“…The airways are densely innervated by sensory afferent nerves, whose activation regulates respiration and triggers defensive reflexes (e.g., cough,…”
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A Novel Flp Reporter Mouse Shows That TRPA1 Expression Is Largely Limited to Sensory Neuron Subsets by Patil, Mayur J, Kim, Seol-Hee, Bahia, Parmvir K, Nair, Sanjay S, Darcey, Teresa S, Fiallo, Jailene, Zhu, Xiao Xia, Frisina, Robert D, Hadley, Stephen H, Taylor-Clark, Thomas E

“…Transient receptor potential ankyrin 1 (TRPA1) is a polymodal cation channel that is activated by electrophilic irritants, oxidative stress, cold temperature,…”
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Development of a Mouse Reporter Strain for the Purinergic P2X2 Receptor by Kim, Seol-Hee, Bahia, Parmvir K, Patil, Mayur, Sutton, Sydney, Sowells, Isobel, Hadley, Stephen H, Kollarik, Marian, Taylor-Clark, Thomas E

“…The ATP-sensitive P2X 2 ionotropic receptor plays a critical role in a number of signal processes including taste and hearing, carotid body detection of…”
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Development of a Mouse Reporter Strain for the Purinergic P2X 2 Receptor by Kim, Seol-Hee, Bahia, Parmvir K, Patil, Mayur, Sutton, Sydney, Sowells, Isobel, Hadley, Stephen H, Kollarik, Marian, Taylor-Clark, Thomas E

“…The ATP-sensitive P2X ionotropic receptor plays a critical role in a number of signal processes including taste and hearing, carotid body detection of hypoxia,…”
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A Functional Role for Small-Conductance Calcium-Activated Potassium Channels in Sensory Pathways Including Nociceptive Processes by Bahia, Parmvir K, Suzuki, Rie, Benton, David C. H, Jowett, Amanda J, Chen, Mao Xiang, Trezise, Derek. J, Dickenson, Anthony H, Moss, Guy W. J

“…We investigated the role of small-conductance calcium-activated potassium (SK) and intermediate-conductance calcium-activated potassium channels in modulating…”
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