Search Results - "Bahar, Rumana"

B7-H1-dependent sex-related differences in tumor immunity and immunotherapy responses by Lin, Pei-Yi, Sun, Lishi, Thibodeaux, Suzanne R, Ludwig, Sara M, Vadlamudi, Ratna K, Hurez, Vincent J, Bahar, Rumana, Kious, Mark J, Livi, Carolina B, Wall, Shawna R, Chen, Lieping, Zhang, Bin, Shin, Tahiro, Curiel, Tyler J

“…CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) are immunopathogenic in cancers by impeding tumor-specific immunity. B7-homologue 1 (B7-H1) (CD274) is a…”
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Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas by Seimiya, Mika, O-Wang, Jiyang, Bahar, Rumana, Kawamura, Kiyoko, Wang, Yanqing, Saisho, Hiromitsu, Tagawa, Masatoshi

“…We have identified a CD40-regulated gene, Clast6/E3/LAPTM5, by subtraction of cDNAs derived from resting and CD40 ligand-treated B cells. Clast6/E3/LAPTM5 is…”
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Clast5/Stra13 Is a Negative Regulator of B Lymphocyte Activation by Seimiya, Mika, Bahar, Rumana, Wang, Yanqing, Kawamura, Kiyoko, Tada, Yuji, Okada, Seiji, Hatano, Masahiko, Tokuhisa, Takeshi, Saisho, Hiromitsu, Watanabe, Takeshi, Tagawa, Masatoshi, O-Wang, Jiyang

“…CD40 is a member of the tumor necrosis factor receptor family and mediates a variety of functions of B cells, including B cell survival, proliferation,…”
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Expression of herpes simplex virus‐thymidine kinase gene controlled by a promoter region of the midkine gene confers selective cytotoxicity to ganciclovir in human carcinoma cells by Miyauchi, Motohiro, Yoshida, Yu, Tada, Yuji, Narita, Mitsuro, Maeda, Tomoko, Bahar, Rumana, Kadomatsu, Kenji, Muramatsu, Takashi, Matsubara, Shuichiro, Nakagawara, Akira, Sakiyama, Shigeru, Tagawa, Masatoshi

“…A selective expression of suicide gene(s) in tumor cells should produce a preferential cytotoxic effect on tumors. Promoter region(s) of a gene that is…”
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Growth Retardation, Polyploidy, and Multinucleation Induced by Clast3, a Novel Cell Cycle-regulated Protein by Bahar, Rumana, O-Wang, Jiyang, Kawamura, Kiyoko, Seimiya, Mika, Wang, Yanqing, Hatano, Masahiko, Okada, Seiji, Tokuhisa, Takeshi, Watanabe, Takeshi, Tagawa, Masatoshi

“…We have identified a novel gene, Clast3 , by subtraction of cDNAs derived from activated and naive B lymphocytes. Clast3 expression is elevated in cycling…”
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Increased cell-to-cell variation in gene expression in ageing mouse heart by Klein, Christoph A, Chisholm, Gary B, Rodriguez, Karl A, Busuttil, Rita A, Denny, Ashley D, Dollé, Martijn E. T, Bahar, Rumana, Hartmann, Claudia H, Calder, R. Brent, Vijg, Jan, Pollock, Brad H

“…The accumulation of somatic DNA damage has been implicated as a cause of ageing in metazoa. One possible mechanism by which increased DNA damage could lead to…”
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Tissue-specific expression of a suicide gene for selective killing of neuroblastoma cells using a promoter region of the NCX gene by Narita, M, Bahar, R, Hatano, M, Kang, M M, Tokuhisa, T, Goto, S, Saisho, H, Sakiyama, S, Tagawa, M

“…The human NCX gene, a homologue of the murine neural crest homeobox (Ncx/Hox11L.1) gene whose expression is restricted to a subset of neural crest-derived…”
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Transduction of the human deoxycytidine kinase gene in rodent tumor cells induces in vivo growth retardation in syngeneic hosts by Kawamura, Kiyoko, Namba, Hiroki, Bahar, Rumana, Miyauchi, Motohiro, Maeda, Tomoko, Hamada, Hirofumi, Sakiyama, Shigeru, Tagawa, Masatoshi

“…Deoxycytidine kinase (dCK) mediates the phosphorylation of nucleoside analogues that can be used as anti-cancer agents. We examined whether susceptibility of…”
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Genome dynamics and transcriptional deregulation in aging by Busuttil, R, Bahar, R, Vijg, J

“…Abstract Genome instability has been implicated as a major cause of both cancer and aging. Using a lacZ -plasmid transgenic mouse model we have shown that…”
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DNA polymerase θ is preferentially expressed in lymphoid tissues and upregulated in human cancers by Kawamura, Kiyoko, Bahar, Rumana, Seimiya, Mika, Chiyo, Masako, Wada, Akihiko, Okada, Seiji, Hatano, Masahiko, Tokuhisa, Takeshi, Kimura, Hideki, Watanabe, Satoshi, Honda, Ichiro, Sakiyama, Shigeru, Tagawa, Masatoshi, O‐Wang, Jiyang

“…DNA polymerase θ (Pol θ) is a recently identified family A polymerase that contains an intrinsic helicase domain. Drosophila Pol θ mutants are hypersensitive…”
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Aging and Genome Maintenance by VIJG, JAN, BUSUTTIL, RITA A., BAHAR, RUMANA, DOLLÉ, MARTIJN E.T.

“…Genomic instability in somatic cells has been implicated as a major stochastic mechanism of aging. Using a transgenic mouse model with chromosomally integrated…”
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In vivo responses to vaccination with Mage-b, GM-CSF and thioglycollate in a highly metastatic mouse breast tumor model, 4T1 by Gravekamp, Claudia, Leal, Belinda, Denny, Ashley, Bahar, Rumana, Lampkin, Shellye, Castro, Francisco, Kim, Sun Hee, Moore, Dan, Reddick, Robert

“…Metastatic breast cancer is an important contributor to morbidity and mortality. Hence, new therapies are needed that target breast cancer metastases. Here, we…”
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Secretion of interleukin-10 from murine colon carcinoma cells suppresses systemic antitumor immunity and impairs protective immunity induced against the tumors by Kawamura, Kiyoko, Bahar, Rumana, Natsume, Waka, Sakiyama, Shigeru, Tagawa, Masatoshi

“…Interleukin-10 (IL-10) is a T helper type 2 (Th2) cytokine that suppresses Th1-mediated, cell-mediated immune responses and reciprocally enhances…”
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CD44 variant 6 (CD44v6) expression as a progression marker in benign, premalignant and malignant oral epithelial tissues by Bahar, Rumana, Kunishi, Masanori, Kayada, Yoshiaki, Yoshiga, Koji

“…The change in the expression pattern of CD44 variant 6 (CD44v6) protein in benign, premalignant, and malignant (SCC) oral epithelial lesions was studied…”
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A promoter region of midkine gene can activate transcription of an exogenous suicide gene in human pancreatic cancer by Yoshida, Yu, Tomizawa, Minoru, Bahar, Rumana, Miyauchi, Motohiro, Yamaguchi, Taketo, Saisho, Hiromitsu, Kadomatsu, Kenji, Muramatsu, Takashi, Matsubara, Shuichiro, Sakiyama, Shigeru, Tagawa, Masatoshi

“…We examined a possible application of regulatory regions of the midkine (MK) gene for suicide gene therapy of pancreatic cancer. The expression of MK has been…”
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The error-prone DNA polymerase zeta catalytic subunit (Rev3) gene is ubiquitously expressed in normal and malignant human tissues by Kawamura, K, O-Wang, J, Bahar, R, Koshikawa, N, Shishikura, T, Nakagawara, A, Sakiyama, S, Kajiwara, K, Kimura, M, Tagawa, M

“…Mutagenesis induced by UV light and chemical agents in yeast is largely dependent on the function of Rev3, the catalytic subunit of DNA polymerase zeta that…”
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Bystander effect in uracil phosphoribosyltransferase/5-fluorouracil-mediated suicide gene therapy is correlated with the level of intercellular communication by Kawamura, K, Bahar, R, Namba, H, Seimiya, M, Takenaga, K, Hamada, H, Sakiyama, S, Tagawa, M

“…We examined whether a suicide gene/prodrug system using the uracil phosphoribosyltransferase (UPRT) of E. coli origin and 5-fluorouracil (5-FU) could achieve a…”
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