Search Results - "Bahamon, Brittany"

The Glomuvenous Malformation Protein Glomulin Binds Rbx1 and Regulates Cullin RING Ligase-Mediated Turnover of Fbw7 by Tron, Adriana E., Arai, Takehiro, Duda, David M., Kuwabara, Hiroshi, Olszewski, Jennifer L., Fujiwara, Yuko, Bahamon, Brittany N., Signoretti, Sabina, Schulman, Brenda A., DeCaprio, James A.

“…Fbw7, a substrate receptor for Cul1-RING-ligase (CRL1), facilitates the ubiquitination and degradation of several proteins, including Cyclin E and c-Myc. In…”
Get full text

Development and Validation of an ERCC1 Immunohistochemistry Assay for Solid Tumors by Bahamon, Brittany N, Gao, Feng, Danaee, Hadi

“…- Excision repair cross-complementation 1 (ERCC1) is a key enzyme in nuclear excision repair pathway and has a critical role in helping remove DNA adducts…”
Get full text

Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor by Niu, Huifeng, Shin, Hyunjin, Gao, Feng, Zhang, Jacob, Bahamon, Brittany, Danaee, Hadi, Melichar, Bohuslav, Schilder, Russell J., Coleman, Robert L., Falchook, Gerald, Adenis, Antoine, Behbakht, Kian, DeMichele, Angela, Dees, Elizabeth Claire, Perez, Kimberly, Matulonis, Ursula, Sawrycki, Piotr, Huebner, Dirk, Ecsedy, Jeffrey

“…Alisertib (MLN8237) is an investigational, oral, selective Aurora A kinase inhibitor. Aurora A contains two functional single nucleotide polymorphisms (SNPs;…”
Get full text

NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking mice by Newman, Emily L., Chu, Adam, Bahamón, Brittany, Takahashi, Aki, DeBold, Joseph F., Miczek, Klaus A.

“…Rationale Memantine is a potential treatment for alcoholic patients, yet few studies investigate the effect of concurrent treatment with memantine and ethanol…”
Get full text

Randomized Phase II Study of Paclitaxel plus Alisertib versus Paclitaxel plus Placebo as Second-Line Therapy for SCLC: Primary and Correlative Biomarker Analyses by Owonikoko, Taofeek K, Niu, Huifeng, Nackaerts, Kristiaan, Csoszi, Tibor, Ostoros, Gyula, Mark, Zsuzsanna, Baik, Christina, Joy, Anil Abraham, Chouaid, Christos, Jaime, Jesus Corral, Kolek, Vitezslav, Majem, Margarita, Roubec, Jaromir, Santos, Edgardo S, Chiang, Anne C, Speranza, Giovanna, Belani, Chandra P, Chiappori, Alberto, Patel, Manish R, Czebe, Krisztina, Byers, Lauren, Bahamon, Brittany, Li, Cong, Sheldon-Waniga, Emily, Kong, Eric F, Williams, Miguel, Badola, Sunita, Shin, Hyunjin, Bedford, Lisa, Ecsedy, Jeffrey A, Bryant, Matthew, Jones, Sian, Simmons, John, Leonard, E Jane, Ullmann, Claudio Dansky, Spigel, David R

“…We assessed the Aurora A kinase inhibitor, alisertib, plus paclitaxel (henceforth referred to as alisertib/paclitaxel) as second-line treatment for SCLC. In…”
Get more information

A phase I, first-in-human study of TAK-164, an antibody–drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C by Kim, Richard, Leal, Alexis D., Parikh, Aparna, Ryan, David P., Wang, Shining, Bahamon, Brittany, Gupta, Neeraj, Moss, Aaron, Pye, Joanna, Miao, Harry, Inguilizian, Haig, Cleary, James M.

“…Purpose Guanylyl cyclase C (GCC) is highly expressed in several gastrointestinal malignancies and preclinical studies suggest that it is a promising target for…”
Get full text

Correction to: A phase I, first-in-human study of TAK-164, an antibody–drug conjugate, in patients with advanced gastrointestinal cancers expressing guanylyl cyclase C by Kim, Richard, Leal, Alexis D., Parikh, Aparna, Ryan, David P., Wang, Shining, Bahamon, Brittany, Gupta, Neeraj, Moss, Aaron, Pye, Joanna, Miao, Harry, Inguilizian, Haig, Cleary, James M.

Get full text

A phase 1 study of TAK-164, an anti-guanylyl cyclase C (GCC) antibody-drug conjugate (ADC), in patients (pts) with advanced gastrointestinal (GI) cancers expressing GCC by Kim, Richard D., Cleary, James M., Leal, Alexis Diane, Parikh, Aparna Raj, Ryan, David P., Wang, Shining, Bahamon, Brittany, Gupta, Neeraj, Moss, Aaron, Pye, Joanna, Miao, Harry H., Bendell, Johanna C.

“…Abstract only 3050 Background: TAK-164 is a second-generation ADC comprising a human IgG1 monoclonal antibody targeting GCC conjugated to a DNA-damaging…”
Get full text

Sapanisertib Plus Exemestane or Fulvestrant in Women with Hormone Receptor-Positive/HER2-Negative Advanced or Metastatic Breast Cancer by Lim, Bora, Potter, David A, Salkeni, Mohamad A, Silverman, Paula, Haddad, Tufia C, Forget, Frederic, Awada, Ahmad, Canon, Jean-Luc, Danso, Michael, Lortholary, Alain, Bourgeois, Hugues, Tan-Chiu, Elizabeth, Vincent, Sylvie, Bahamon, Brittany, Galinsky, Kevin J, Patel, Chirag, Neuwirth, Rachel, Leonard, E Jane, Diamond, Jennifer R

“…This open-label, multicenter, phase IB/II study evaluated sapanisertib, a dual inhibitor of mTOR kinase complexes 1/2, plus exemestane or fulvestrant in…”
Get full text

The Role of Aberrant VHL/HIF Pathway Elements in Predicting Clinical Outcome to Pazopanib Therapy in Patients with Metastatic Clear-Cell Renal Cell Carcinoma by CHOUEIRI, Toni K, FAY, André P, YUAN LIU, PANDITE, Lini, SIGNORETTI, Sabina, GAGNON, Robert, YING LIN, BAHAMON, Brittany, BROWN, Victoria, ROSENBERG, Jonathan E, HUTSON, Thomas E, BAKER-NEBLETT, Katherine L, CARPENTER, Christopher

“…Inactivation of von Hippel-Lindau (VHL) gene in clear-cell renal cell carcinoma (RCC) leads to increased levels of hypoxia-inducible factors (HIF) and…”
Get full text

Abstract 3916: Relationship of guanylyl cyclase C (GCC) expression and efficacy of TAK-164, a GCC-targeted antibody-drug conjugate in a panel of 68 subcutaneous HuPrime colorectal cancer PDX models by Koenig, Erik M., Li, Cong, Yang, Huyuan, Zhu, Andy, Shah, Pooja, Nishimura, Kazuho, Bannerman, Bret, zhang, Mengkun, Stringer, Bradley, Bahamon, Brittany, Veiby, O. Petter, Abu-Yousif, Adnan

“…Guanylyl cyclase C (GCC) is a cell surface protein expressed in more than 95% of metastatic colorectal cancers and in the majority of gastric and pancreatic…”
Get full text

Abstract 4535: Automated image analysis algorithm development for cell surface-binding therapeutic agent target & its comparison to manual pathology scoring by Bahamon, Brittany, Cholewinski, Andrzej, Cardenes, Ruben, Zuraw, Aleksandra, Barragan, Israel, McNeeley, Marise B., Luff, Ronald D., Abu-Yousif, Adnan, Danaee, Hadi

“…Standard pathology scoring of cell surface targets in tumor tissue is done routinely by semi-quantitative scoring and is usually performed by a pathologist…”
Get full text

First-in-human phase 1 study of TAK-931, an oral cell division cycle 7 (CDC7) inhibitor, in patients (pts) with advanced solid tumors by Shimizu, Toshio, Doi, Toshihiko, Kondo, Shunsuke, Takahashi, Hideaki, Yamamoto, Noboru, Sheldon-Waniga, Emily, Zhou, Xiaofei, Bahamon, Brittany, Li, Hongmei, Kuboki, Yasutoshi

“…Abstract only…”
Get full text

Correlation of an Aurora A single nucleotide polymorphism (SNP) with clinical responses to alisertib in patients (pts) with advanced solid tumors by Niu, Huifeng, Shin, Hyunjin, Gao, Feng, Zhang, Jacob, Bahamon, Brittany, Danaee, Hadi, Melichar, Bohuslav, Schilder, Russell J., Coleman, Robert L., Adenis, Antoine, Behbakht, Kian, DeMichele, Angela, Dees, Elizabeth Claire, Perez, Kimberly, Matulonis, Ursula A., Huebner, Dirk, Ecsedy, Jeffrey

“…Abstract only…”
Get full text

NMDA receptor antagonism: escalation of aggressive behavior in alcohol-drinking mice: Drug Action in Social Context by NEWMAN, Emily L, CHU, Adam, BAHAMON, Brittany, TAKAHASHI, Aki, DEBOLD, Joseph F, MICZEK, Klaus A

Get full text

Abstract LB-313: ALK1-Fc inhibits tumor growth in a VEGF pathway resistance model of renal cell carcinoma by Wang, Xiaoen, Solban, Nicolas, Bhasin, Manoj K., Bahamon, Brittany, Zhang, Liang, Signoretti, Sabina, Alsop, David C., Atkins, Michael B., Pearsall, R. Scott, Mier, James W., Kumar, Ravindra, Bhatt, Rupal S.

“…Treatment of metastatic RCC with agents that block signaling through VEGFR2 induces disease stabilization or regression in a substantial fraction of patients…”
Get full text