Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum Linn

The article offers dataset on the expression of serotonergic nerve in the hippocampal area of Alzheimer's disease (AD) model. Since decreasing expression of serotonin linked to dementia, this data will help the neuroscientist, who work on neurodegeneration. This dataset demonstrates the potenti...

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Bibliographic Details
Published in:	Data in brief Vol. 30; p. 105654
Main Authors:	Raditya, M. Nova, Bagus, A.M. Made, Kustiati, Ulayatul, Wihadmadyatami, Hevi, Kusindarta, Dwi Liliek
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-06-2020 Elsevier
Subjects:	Hippocampal Medicine and Dentistry Neurodegenerative disease Ocimum sanctum Linn. Ethanolic extract Serotonin Neurodegenerative disease Hippocampal Ocimum sanctum Linn. Ethanolic extract Serotonin
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Summary:	The article offers dataset on the expression of serotonergic nerve in the hippocampal area of Alzheimer's disease (AD) model. Since decreasing expression of serotonin linked to dementia, this data will help the neuroscientist, who work on neurodegeneration. This dataset demonstrates the potential of Ocimum sanctum Extract (OSE) as a neuroprotective and neurodegenerative agent against AD. The OSE mechanism focusing on the expression of serotonin as a therapeutic target. To acquire the dataset, we approached using two models, in vitro and in vivo. On the In vivo model, used two months old 27 male rats and divided into three groups, non-treated (Group A, n=9), AD rats model pre-treated with OSE followed induction for TMT on the days of seventh (group B, n=9) and AD rats model treated with OSE both on pre-TMT introduction for seven days and post-TMT induction for 21 days (group C, n=9). AD rats euthanised on day seventh; 14th; and 21st. The brain samples were analysed for neuronal density and serotonin immunoreactivity qualitatively. Besides, In Vitro's data were collected from HEK-293 cells which induce by TMT as of AD model. The data expression of serotonin on the in-vitro model analysed using ELISA method.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2352-3409 2352-3409
DOI:	10.1016/j.dib.2020.105654