Aloin protects against arsenic trioxide–induced myocardial membrane damage and release of inflammatory cytokines
Aloin exerts concentration-dependent pro-oxidant and antioxidant effects when tested in vitro. Such duality of effects has not been investigated through in vivo studies on aloin. We evaluated the effects of aloin at doses ranging between 1 and 125 mg/kg against the arsenic trioxide (As 2 O 3 )–induc...
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| Published in: | Naunyn-Schmiedeberg's archives of pharmacology Vol. 393; no. 8; pp. 1365 - 1372 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Berlin/Heidelberg
Springer Berlin Heidelberg
01-08-2020
Springer Nature B.V |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Aloin exerts concentration-dependent pro-oxidant and antioxidant effects when tested in vitro. Such duality of effects has not been investigated through in vivo studies on aloin. We evaluated the effects of aloin at doses ranging between 1 and 125 mg/kg against the arsenic trioxide (As
2
O
3
)–induced cardiotoxicity in mice. As
2
O
3
(5 mg/kg/day) was intraperitoneally administrated for 10 days. Aloin was administered through oral gavage at 1, 5, 25, and 125 mg/kg/day. As
2
O
3
induced rise in ST height and QT interval in ECG, increased oxidative stress, and depleted the antioxidative defense. As
2
O
3
increased inflammatory cytokine concentrations in the heart. Aloin dose dependently inhibited the As
2
O
3
-induced cardiotoxicity. There was no evidence of increased oxidative stress in the low-dose aloin-treated mice receiving As
2
O
3.
Our results indicate that aloin possesses cardioprotective potentials and its pro-oxidant effect is not evident in vivo at tested doses. |
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| ISSN: | 0028-1298 1432-1912 |
| DOI: | 10.1007/s00210-020-01833-1 |