Search Results - "Bagley, Joshua A."

Genetically engineered cerebral organoids model brain tumor formation by Bian, Shan, Repic, Marko, Guo, Zhenming, Kavirayani, Anoop, Burkard, Thomas, Bagley, Joshua A., Krauditsch, Christian, Knoblich, Jürgen A.

“…Brain tumors are among the most lethal and devastating cancers. Their study is limited by genetic heterogeneity and the incompleteness of available laboratory…”
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Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects by Kwon, Min Jee, Han, Myeong Hoon, Bagley, Joshua A., Hyeon, Do Young, Ko, Byung Su, Lee, Yun Mi, Cha, In Jun, Kim, Seung Yeol, Kim, Dong Young, Kim, Ho Min, Hwang, Daehee, Lee, Sung Bae, Jan, Yuh Nung

“…Neurodegenerative disorders, such as Huntington’s diseases and spinocerebellar ataxias (SCAs), are driven by proteins with expanded polyglutamine (polyQ)…”
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Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons by Meltzer, Shan, Bagley, Joshua A., Perez, Gerardo Lopez, O’Brien, Caitlin E., DeVault, Laura, Guo, Yanmeng, Jan, Lily Yeh, Jan, Yuh-Nung

“…Disruptions in lipid homeostasis have been observed in many neurodevelopmental disorders that are associated with dendrite morphogenesis defects. However, the…”
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Pathogenic polyglutamine proteins cause dendrite defects associated with specific actin cytoskeletal alterations in Drosophila by Lee, Sung Bae, Bagley, Joshua A, Lee, Hye Young, Jan, Lily Yeh, Jan, Yuh-Nung

“…Whereas the neurodegeneration associated with various polyglutamine (polyQ) diseases has prompted extensive studies of polyQ-induced cell death, the neuronal…”
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Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism by Rumpf, Sebastian, Bagley, Joshua A., Thompson-Peer, Katherine L., Zhu, Sijun, Gorczyca, David, Beckstead, Robert B., Jan, Lily Yeh, Jan, Yuh Nung

“…The dendritic arbors of the larval Drosophila peripheral class IV dendritic arborization neurons degenerate during metamorphosis in an ecdysone-dependent…”
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Fused cerebral organoids model interactions between brain regions by Bagley, Joshua A, Reumann, Daniel, Bian, Shan, Lévi-Strauss, Julie, Knoblich, Juergen A

“…The fusion of patterned cerebral organoids into more complex structures enables modeling of inter-regional processes such as neuronal migration. Human brain…”
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A human tissue screen identifies a regulator of ER secretion as a brain-size determinant by Esk, Christopher, Lindenhofer, Dominik, Haendeler, Simon, Wester, Roelof A, Pflug, Florian, Schroeder, Benoit, Bagley, Joshua A, Elling, Ulrich, Zuber, Johannes, von Haeseler, Arndt, Knoblich, Jürgen A

“…Loss-of-function (LOF) screens provide a powerful approach to identify regulators in biological processes. Pioneered in laboratory animals, LOF screens of…”
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Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration by Bajaj, Sunanjay, Bagley, Joshua A, Sommer, Christoph, Vertesy, Abel, Nagumo Wong, Sakurako, Krenn, Veronica, Lévi‐Strauss, Julie, Knoblich, Juergen A

“…Inhibitory GABAergic interneurons migrate over long distances from their extracortical origin into the developing cortex. In humans, this process is uniquely…”
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Human blood vessel organoids as a model of diabetic vasculopathy by Wimmer, Reiner A., Leopoldi, Alexandra, Aichinger, Martin, Wick, Nikolaus, Hantusch, Brigitte, Novatchkova, Maria, Taubenschmid, Jasmin, Hämmerle, Monika, Esk, Christopher, Bagley, Joshua A., Lindenhofer, Dominik, Chen, Guibin, Boehm, Manfred, Agu, Chukwuma A., Yang, Fengtang, Fu, Beiyuan, Zuber, Johannes, Knoblich, Juergen A., Kerjaschki, Dontscho, Penninger, Josef M.

“…The increasing prevalence of diabetes has resulted in a global epidemic 1 . Diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and…”
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Author Correction: Genetically engineered cerebral organoids model brain tumor formation by Bian, Shan, Repic, Marko, Guo, Zhenming, Kavirayani, Anoop, Burkard, Thomas, Bagley, Joshua A., Krauditsch, Christian, Knoblich, Jürgen A.

“…In the originally published paper, the “before” image for the afatinib condition in Fig. 6c was incorrect. Instead of an image displaying a GBM-3 neoplastic…”
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Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function by Bagley, Joshua A, Yan, Zhiqiang, Zhang, Wei, Wildonger, Jill, Jan, Lily Yeh, Jan, Yuh Nung

“…A complex array of genetic factors regulates neuronal dendrite morphology. Epigenetic regulation of gene expression represents a plausible mechanism to control…”
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Genetically engineered cerebral organoids model brain tumor formation by Bian, Shan, Repic, Marko, Guo, Zhenming, Kavirayani, Anoop, Burkard, Thomas, Bagley, Joshua A., Krauditsch, Christian, Knoblich, Jürgen A.

“…Brain tumors are among the most lethal and devastating cancers. Their study is limited by genetic heterogeneity and the incompleteness of available laboratory…”
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Fused dorsal-ventral cerebral organoids model complex interactions between diverse brain regions by Bagley, Joshua A, Reumann, Daniel, Bian, Shan, Lévi-Strauss, Julie, Knoblich, Juergen A

“…Human brain development involves complex interactions between different areas, including long distance neuronal migration or formation of major axonal tracts…”
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Dynamic imaging reveals that BDNF can independently regulate motility and direction of RMS neuroblast migration by Bagley, Joshua A., Belluscio, Leonardo

“…Neuronal precursors generated in the subventricular zone (SVZ) migrate through the rostral migratory stream (RMS) to the olfactory bulb (OB). Although, the…”
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The Molecular Regulation of Dendritic Arbor Shape during Development and Disease by Bagley, Joshua A

“…The brain is composed of a network of neural cells which have elaborate cellular structures, especially their dendritic arbors. The correct function of neural…”
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The Molecular Regulation of Dendritic Arbor Shape during Development and Disease by Bagley, Joshua A

“…The brain is composed of a network of neural cells which have elaborate cellular structures, especially their dendritic arbors. The correct function of neural…”
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