Search Results - "Baghdoyan, Sandrine"

Pluripotent Stem Cells in Disease Modeling and Drug Discovery for Myotonic Dystrophy Type 1 by Bérenger-Currias, Noémie, Martinat, Cécile, Baghdoyan, Sandrine

“…Myotonic dystrophy type 1 (DM1) is a progressive multisystemic disease caused by the expansion of a CTG repeat tract within the 3' untranslated region (3' UTR)…”
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In Vitro and In Vivo Modulation of Alternative Splicing by the Biguanide Metformin by Laustriat, Delphine, Gide, Jacqueline, Barrault, Laetitia, Chautard, Emilie, Benoit, Clara, Auboeuf, Didier, Boland, Anne, Battail, Christophe, Artiguenave, François, Deleuze, Jean-François, Bénit, Paule, Rustin, Pierre, Franc, Sylvia, Charpentier, Guillaume, Furling, Denis, Bassez, Guillaume, Nissan, Xavier, Martinat, Cécile, Peschanski, Marc, Baghdoyan, Sandrine

“…Major physiological changes are governed by alternative splicing of RNA, and its misregulation may lead to specific diseases. With the use of a genome-wide…”
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Pluripotent Stem Cell-Based Drug Screening Reveals Cardiac Glycosides as Modulators of Myotonic Dystrophy Type 1 by Maury, Yves, Poydenot, Pauline, Brinon, Benjamin, Lesueur, Lea, Gide, Jacqueline, Roquevière, Sylvain, Côme, Julien, Polvèche, Hélène, Auboeuf, Didier, Alexandre Denis, Jérome, Pietu, Geneviève, Furling, Denis, Lechuga, Marc, Baghdoyan, Sandrine, Peschanski, Marc, Martinat, Cécile

“…There is currently no treatment for myotonic dystrophy type 1 (DM1), the most frequent myopathy of genetic origin. This progressive neuromuscular disease is…”
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Improved mobility with metformin in patients with myotonic dystrophy type 1: a randomized controlled trial by Bassez, Guillaume, Audureau, Etienne, Hogrel, Jean-Yves, Arrouasse, Raphaëlle, Baghdoyan, Sandrine, Bhugaloo, Hamza, Gourlay-Chu, Marie-Laurence, Le Corvoisier, Philippe, Peschanski, Marc

“…Metformin, the classic anti-diabetic drug, improves motor symptoms in the DMSXL mouse model of myotonic dystrophy type 1. Bassez et al. now report a…”
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Capture of cytokine-responsive genes (NACA and RBM3) using a gene trap approach by BAGHDOYAN, S, DUBREUIL, P, EBERLE, F, GOMEZ, S

“…We have developed a gene trap approach to select specific cytokine receptor/ligand responsive genes in the cell line TF-1. This cell line exhibits a dependency…”
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Capture of cytokine-responsive genes (NACA and RBM3) using a gene trap approach by Baghdoyan, Sandrine, Dubreuil, Patrice, Eberlé, Frédéric, Gomez, Sophie

“…We have developed a gene trap approach to select specific cytokine receptor/ligand responsive genes in the cell line TF-1. This cell line exhibits a dependency…”
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Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood by van Cruchten, Remco T. P., van As, Daniël, Glennon, Jeffrey C., van Engelen, Baziel G. M., ‘t Hoen, Peter A. C., Okkersen, K, Jimenez-Moreno, C, Wenninger, S, Daidj, F, Cumming, S, Littleford, R, Monckton, D G, Lochmüller, H, Catt, M, Faber, C G, Hapca, A, Donnan, P T, Gorman, G, Bassez, G, Schoser, B, Knoop, H, Treweek, S, Wansink, Derick G., Impens, Francis, Gabriels, Ralf, Claeys, Tine, Ravel-Chapuis, Aymeric, Jasmin, Bernard J., Mahon, Niamh, Nieuwenhuis, Sylvia, Martens, Lennart, Novak, Petr, Furling, Denis, Baak, Arie, Gourdon, Genevieve, MacKenzie, Alex, Martinat, Cecile, Neault, Nafisa, Roos, Andreas, Duchesne, Elise, Salz, Renee, Thompson, Rachel, Baghdoyan, Sandrine, Varghese, Anu Mary, Blom, Paul, Spendiff, Sally, Manta, Alexander

“…Abstract Background Myotonic dystrophy type 1 (DM1) is an incurable multisystem disease caused by a CTG-repeat expansion in the DM1 protein kinase ( DMPK )…”
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Expression of miRNAs from the Imprinted DLK1/DIO3 Locus Signals the Osteogenic Potential of Human Pluripotent Stem Cells by Barrault, Laetitia, Gide, Jacqueline, Qing, Tingting, Lesueur, Lea, Tost, Jorg, Denis, Jerome Alexandre, Cailleret, Michel, Aubry, Laetitia, Peschanski, Marc, Martinat, Cécile, Baghdoyan, Sandrine

“…Substantial variations in differentiation properties have been reported among human pluripotent cell lines (hPSC), which could affect their utility and…”
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Pharmacological research and pluripotent stem cells: from the innovative experimental paradigm to the successful clinical trial by Baghdoyan, Sandrine, Bassez, Guillaume, Audureau, Etienne, Peschanski, Marc

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Quantitative analysis of highly parallel transfection in cell microarrays by Baghdoyan, Sandrine, Roupioz, Yoann, Pitaval, Amandine, Castel, David, Khomyakova, Elena, Papine, Alexandre, Soussaline, Françoise, Gidrol, Xavier

“…As more genomes are sequenced, we are facing the challenge of rapidly unraveling the functions of genes. To that end, cell microarrays have recently been…”
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Id2 Reverses Cell Cycle Arrest Induced by γ-Irradiation in Human HaCaT Keratinocytes by Baghdoyan, Sandrine, Lamartine, Jérôme, Castel, David, Pitaval, Amandine, Roupioz, Yoann, Franco, Noreli, Duarte, Mariela, Martin, Michèle T., Gidrol, Xavier

“…Id2 plays a key role in epithelial cells, regulating differentiation, the cell cycle, and proliferation. Because human skin constantly renews itself and is the…”
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Id2 reverses cell cycle arrest induced by {gamma}-irradiation in human HaCaT keratinocytes by Baghdoyan, Sandrine, Lamartine, Jérôme, Castel, David, Pitaval, Amandine, Roupioz, Yoann, Franco, Noreli, Duarte, Mariela, Martin, Michèle T, Gidrol, Xavier

“…Id2 plays a key role in epithelial cells, regulating differentiation, the cell cycle, and proliferation. Because human skin constantly renews itself and is the…”
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Id2 Reverses Cell Cycle Arrest Induced by g-Irradiation in Human HaCaT Keratinocytes by Baghdoyan, Sandrine, Lamartine, Jerome, Castel, David, Pitaval, Amandine, Roupioz, Yoann, Franco, Noreli, Duarte, Mariela, Martin, Michele T, Gidrol, Xavier

“…Id2 plays a key role in epithelial cells, regulating differentiation, the cell cycle, and proliferation. Because human skin constantly renews itself and is the…”
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Id2 Reverses Cell Cycle Arrest Induced by γ-Irradiation in Human HaCaT Keratinocytes by Sandrine Baghdoyan, Jérôme Lamartine, David Castel, Amandine Pitaval, Yoann Roupioz, Noreli Franco, Mariela Duarte, Michèle T. Martin, Xavier Gidrol

“…Id2 plays a key role in epithelial cells, regulating differentiation, the cell cycle, and proliferation. Because human skin constantly renews itself and is the…”
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Cell microarrays and functional genomics by Roupioz, Yoann, Castel, David, Pitaval, Amandine, Baghdoyan, Sandrine, Gidrol, Xavier

“…With the complete sequencing of the human genome, research priorities have shifted from the identification of genes to the elucidation of their function…”
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