Is high-dose cholecalciferol justified in children with chronic kidney disease who failed low-dose maintenance therapy?

Is high-dose cholecalciferol justified in children with chronic kidney disease who failed low-dose maintenance therapy?

Background We aimed to investigate the effect of single, high-dose intramuscular cholecalciferol on vitamin D3 and intact parathyroid hormone (iPTH) levels in children with chronic kidney disease (CKD). Methods Between January 2012 and June 2012, we conducted a prospective, uncontrolled study at the...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) Vol. 28; no. 6; pp. 933 - 937
Main Authors: Kari, Jameela Abdulaziz, Baghdadi, Osama T., El-Desoky, Sherif
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer-Verlag 01-06-2013
Springer
Springer Nature B.V
Subjects:
Adolescent
Bone diseases
Child
Child, Preschool
Cholecalciferol - administration & dosage
Cholecalciferol - blood
Cholecalciferol - therapeutic use
Chronic kidney failure
Complications and side effects
Creatinine
Creatinine - blood
Dosage and administration
Drug therapy
Female
Humans
Kidney diseases
Male
Medicine
Medicine & Public Health
Nephrology
Original Article
Parathyroid hormone
Parathyroid Hormone - blood
Pediatrics
Phosphatase
Physiological aspects
Prospective Studies
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - drug therapy
Social sciences
Statistical analysis
Urology
Vitamin D
Vitamin D3
Saudi Arabia
United States > US
Vitamin D insufficiency/deficiency
Intramuscular cholecalciferol
Chronic kidney disease
Chronic kidney disease-mineral bone disorder
Children
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Summary:Background We aimed to investigate the effect of single, high-dose intramuscular cholecalciferol on vitamin D3 and intact parathyroid hormone (iPTH) levels in children with chronic kidney disease (CKD). Methods Between January 2012 and June 2012, we conducted a prospective, uncontrolled study at the Pediatric Nephrology Unit of King Abdulaziz University Hospital, Jeddah, to investigate the effect of single, high-dose intramuscular vitamin D3 on 25(OH)D3 and iPTH levels in vitamin D insufficient/deficient children with CKD. Serum vitamin D3, iPTH, calcium, phosphate, alkaline phosphatase (ALP), and creatinine levels were measured before intramuscular vitamin D3 (300,000 IU) administration, and these were subsequently repeated at 1 and 3 months after treatment. Statistical analysis was performed with the Statistical Package for the Social Sciences (SPSS Inc., Chicago, IL, USA). Results Nineteen children fulfilled the criteria. At 3 months after treatment, vitamin D3 levels were significantly higher than at baseline ( p  < 0.001) but lower than the levels at 1 month. iPTH levels decreased significantly at 3 months ( p  = 0.01); however, the drop in iPTH levels was not significant at 1 month ( p  = 0.447). There were no changes in calcium, phosphate, ALP, or creatinine levels after treatment. Conclusions Single-dose intramuscular vitamin D3 (300,000 IU) resulted in significant improvement of vitamin D3 and iPTH levels in children with CKD.
Bibliography:ObjectType-Article-2
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ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-012-2407-2