Search Results - "Baggerly, Keith"

Maternal 25(OH)D concentrations ≥40 ng/mL associated with 60% lower preterm birth risk among general obstetrical patients at an urban medical center by McDonnell, Sharon L, Baggerly, Keith A, Baggerly, Carole A, Aliano, Jennifer L, French, Christine B, Baggerly, Leo L, Ebeling, Myla D, Rittenberg, Charles S, Goodier, Christopher G, Mateus Niño, Julio F, Wineland, Rebecca J, Newman, Roger B, Hollis, Bruce W, Wagner, Carol L

“…Given the high rate of preterm birth (PTB) nationwide and data from RCTs demonstrating risk reduction with vitamin D supplementation, the Medical University of…”
Get full text

Differential Response to Neoadjuvant Chemotherapy Among 7 Triple-Negative Breast Cancer Molecular Subtypes by MASUDA, Hiroko, BAGGERLY, Keith A, FRASER SYMMANS, W, UENO, Naoto T, YING WANG, YA ZHANG, GONZALEZ-ANGULO, Ana Maria, MERIC-BERNSTAM, Funda, VALERO, Vicente, LEHMANN, Brian D, PIETENPOL, Jennifer A, HORTOBAGYI, Gabriel N

“…The clinical relevancy of the 7-subtype classification of triple-negative breast cancer (TNBC) reported by Lehmann and colleagues is unknown. We investigated…”
Get full text

Tackling the widespread and critical impact of batch effects in high-throughput data by Irizarry, Rafael A, Leek, Jeffrey T, Scharpf, Robert B, Bravo, Héctor Corrada, Simcha, David, Langmead, Benjamin, Johnson, W. Evan, Geman, Donald, Baggerly, Keith

“…Batch effects can lead to incorrect biological conclusions but are not widely considered. The authors show that batch effects are relevant to a range of…”
Get full text

Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers by Aparicio, Ana M, Shen, Li, Tapia, Elsa Li Ning, Lu, Jing-Fang, Chen, Hsiang-Chun, Zhang, Jiexin, Wu, Guanglin, Wang, Xuemei, Troncoso, Patricia, Corn, Paul, Thompson, Timothy C, Broom, Bradley, Baggerly, Keith, Maity, Sankar N, Logothetis, Christopher J

“…Morphologically heterogeneous prostate cancers that behave clinically like small-cell prostate cancers (SCPC) share their chemotherapy responsiveness. We asked…”
Get full text

Gene Expression Profile of the Clinically Aggressive Micropapillary Variant of Bladder Cancer by Guo, Charles Chuanhai, Dadhania, Vipulkumar, Zhang, Li, Majewski, Tadeusz, Bondaruk, Jolanta, Sykulski, Maciej, Wronowska, Weronika, Gambin, Anna, Wang, Yan, Zhang, Shizhen, Fuentes-Mattei, Enrique, Kamat, Ashish Madhav, Dinney, Colin, Siefker-Radtke, Arlene, Choi, Woonyoung, Baggerly, Keith A, McConkey, David, Weinstein, John N, Czerniak, Bogdan

“…Abstract Background Progression of conventional urothelial carcinoma of the bladder to a tumor with unique microscopic features referred to as micropapillary…”
Get full text

Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration: Independent Statistical Evaluations of Data from the Age-Related Eye Disease Study by Assel, Melissa J, Li, Fan, Wang, Ying, Allen, Andrew S, Baggerly, Keith A, Vickers, Andrew J

“…Considerable controversy has erupted in recent years regarding whether genotyping should be part of standard care for patients with age-related macular…”
Get full text

DERIVING CHEMOSENSITIVITY FROM CELL LINES: FORENSIC BIOINFORMATICS AND REPRODUCIBLE RESEARCH IN HIGH-THROUGHPUT BIOLOGY by Baggerly, Keith A., Coombes, Kevin R.

“…High-throughput biological assays such as microarrays let us ask very detailed questions about how diseases operate, and promise to let us personalize therapy…”
Get full text

FABP4 as a key determinant of metastatic potential of ovarian cancer by Gharpure, Kshipra M., Pradeep, Sunila, Sans, Marta, Rupaimoole, Rajesha, Ivan, Cristina, Wu, Sherry Y., Bayraktar, Emine, Nagaraja, Archana S., Mangala, Lingegowda S., Zhang, Xinna, Haemmerle, Monika, Hu, Wei, Rodriguez-Aguayo, Cristian, McGuire, Michael, Mak, Celia Sze Ling, Chen, Xiuhui, Tran, Michelle A., Villar-Prados, Alejandro, Pena, Guillermo Armaiz, Kondetimmanahalli, Ragini, Nini, Ryan, Koppula, Pranavi, Ram, Prahlad, Liu, Jinsong, Lopez-Berestein, Gabriel, Baggerly, Keith, S. Eberlin, Livia, Sood, Anil K.

“…The standard treatment for high-grade serous ovarian cancer is primary debulking surgery followed by chemotherapy. The extent of metastasis and invasive…”
Get full text

Clinically relevant microRNAs in ovarian cancer by Zhang, Shu, Lu, Zhen, Unruh, Anna K, Ivan, Cristina, Baggerly, Keith A, Calin, George A, Li, Zongfang, Bast, Jr, Robert C, Le, Xiao-Feng

“…microRNAs (miRNAs/miRs) belong to a class of small noncoding RNAs that can negatively regulate messenger RNA (mRNA) expression of target genes. miRNAs are…”
Get full text

Tumour angiogenesis regulation by the miR-200 family by Pecot, Chad V., Rupaimoole, Rajesha, Yang, Da, Akbani, Rehan, Ivan, Cristina, Lu, Chunhua, Wu, Sherry, Han, Hee-Dong, Shah, Maitri Y., Rodriguez-Aguayo, Cristian, Bottsford-Miller, Justin, Liu, Yuexin, Kim, Sang Bae, Unruh, Anna, Gonzalez-Villasana, Vianey, Huang, Li, Zand, Behrouz, Moreno-Smith, Myrthala, Mangala, Lingegowda S., Taylor, Morgan, Dalton, Heather J., Sehgal, Vasudha, Wen, Yunfei, Kang, Yu, Baggerly, Keith A., Lee, Ju-Seog, Ram, Prahlad T., Ravoori, Murali K., Kundra, Vikas, Zhang, Xinna, Ali-Fehmi, Rouba, Gonzalez-Angulo, Ana-Maria, Massion, Pierre P., Calin, George A., Lopez-Berestein, Gabriel, Zhang, Wei, Sood, Anil K.

“…The miR-200 family is well known to inhibit the epithelial–mesenchymal transition, suggesting it may therapeutically inhibit metastatic biology. However,…”
Get full text

Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer by Lee, Sanghoon, Zhao, Li, Rojas, Christine, Bateman, Nicholas W., Yao, Hui, Lara, Olivia D., Celestino, Joseph, Morgan, Margaret B., Nguyen, Tri V., Conrads, Kelly A., Rangel, Kelly M., Dood, Robert L., Hajek, Richard A., Fawcett, Gloria L., Chu, Randy A., Wilson, Katlin, Loffredo, Jeremy L., Viollet, Coralie, Jazaeri, Amir A., Dalgard, Clifton L., Mao, Xizeng, Song, Xingzhi, Zhou, Ming, Hood, Brian L., Banskota, Nirad, Wilkerson, Matthew D., Te, Jerez, Soltis, Anthony R., Roman, Kristin, Dunn, Andrew, Cordover, David, Eterovic, Agda Karina, Liu, Jinsong, Burks, Jared K., Baggerly, Keith A., Fleming, Nicole D., Lu, Karen H., Westin, Shannon N., Coleman, Robert L., Mills, Gordon B., Casablanca, Yovanni, Zhang, Jianhua, Conrads, Thomas P., Maxwell, George L., Futreal, P. Andrew, Sood, Anil K.

“…The diversity and heterogeneity within high-grade serous ovarian cancer (HGSC), which is the most lethal gynecologic malignancy, is not well understood. Here,…”
Get full text

Genome-wide hypomethylation in head and neck cancer is more pronounced in HPV-negative tumors and is associated with genomic instability by Richards, Kristy L, Zhang, Baili, Baggerly, Keith A, Colella, Stefano, Lang, James C, Schuller, David E, Krahe, Ralf

“…Loss of genome-wide methylation is a common feature of cancer, and the degree of hypomethylation has been correlated with genomic instability. Global…”
Get full text

A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer by Wu, Sherry Y., Rupaimoole, Rajesha, Shen, Fangrong, Pradeep, Sunila, Pecot, Chad V., Ivan, Cristina, Nagaraja, Archana S., Gharpure, Kshipra M., Pham, Elizabeth, Hatakeyama, Hiroto, McGuire, Michael H., Haemmerle, Monika, Vidal-Anaya, Viviana, Olsen, Courtney, Rodriguez-Aguayo, Cristian, Filant, Justyna, Ehsanipour, Ehsan A., Herbrich, Shelley M., Maiti, Sourindra N., Huang, Li, Kim, Ji Hoon, Zhang, Xinna, Han, Hee-Dong, Armaiz-Pena, Guillermo N., Seviour, Elena G., Tucker, Sue, Zhang, Min, Yang, Da, Cooper, Laurence J. N., Ali-Fehmi, Rouba, Bar-Eli, Menashe, Lee, Ju-Seog, Ram, Prahlad T., Baggerly, Keith A., Lopez-Berestein, Gabriel, Hung, Mien-Chie, Sood, Anil K.

“…A deeper mechanistic understanding of tumour angiogenesis regulation is needed to improve current anti-angiogenic therapies. Here we present evidence from…”
Get full text

Refining statistics clarifies leukaemic stem cell genomics by Herbrich, Shelley M., Baggerly, Keith A., Konopleva, Marina

Get full text

Functional CAR Models for Large Spatially Correlated Functional Datasets by Zhang, Lin, Baladandayuthapani, Veerabhadran, Zhu, Hongxiao, Baggerly, Keith A., Majewski, Tadeusz, Czerniak, Bogdan A., Morris, Jeffrey S.

“…We develop a functional conditional autoregressive (CAR) model for spatially correlated data for which functions are collected on areal units of a lattice. Our…”
Get full text

Elevation of TP53 Autoantibody Before CA125 in Preclinical Invasive Epithelial Ovarian Cancer by Yang, Wei-Lei, Gentry-Maharaj, Aleksandra, Simmons, Archana, Ryan, Andy, Fourkala, Evangelia Ourania, Lu, Zhen, Baggerly, Keith A, Zhao, Yang, Lu, Karen H, Bowtell, David, Jacobs, Ian, Skates, Steven J, He, Wei-Wu, Menon, Usha, Bast, Jr, Robert C

“…The tumor-suppressor gene is mutated in >95% of high-grade serous ovarian cancers. Detecting an autologous antibody response to TP53 that might improve early…”
Get full text

Surface PD-L1, E-cadherin, CD24, and VEGFR2 as markers of epithelial cancer stem cells associated with rapid tumorigenesis by Jinesh, Goodwin G., Manyam, Ganiraju C., Mmeje, Chinedu O., Baggerly, Keith A., Kamat, Ashish M.

“…Cancer cells require both migratory and tumorigenic property to establish metastatic tumors outside the primary microenvironment. Identifying the…”
Get full text

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment by Zeng, Zhihong, Shi, Yue Xi, Tsao, Twee, Qiu, YiHua, Kornblau, Steven M., Baggerly, Keith A., Liu, Wenbin, Jessen, Katti, Liu, Yi, Kantarjian, Hagop, Rommel, Christian, Fruman, David A., Andreeff, Michael, Konopleva, Marina

“…The interactions between the bone marrow (BM) microenvironment and acute myeloid leukemia (AML) is known to promote survival of AML cells. In this study, we…”
Get full text

Meta-Analysis of the Luminal and Basal Subtypes of Bladder Cancer and the Identification of Signature Immunohistochemical Markers for Clinical Use by Dadhania, Vipulkumar, Zhang, Miao, Zhang, Li, Bondaruk, Jolanta, Majewski, Tadeusz, Siefker-Radtke, Arlene, Guo, Charles C., Dinney, Colin, Cogdell, David E., Zhang, Shizhen, Lee, Sangkyou, Lee, June G., Weinstein, John N., Baggerly, Keith, McConkey, David, Czerniak, Bogdan

“…It has been suggested that bladder cancer can be divided into two molecular subtypes referred to as luminal and basal with distinct clinical behaviors and…”
Get full text

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics by HENNESSY, Bryan T, GONZALEZ-ANGULO, Ana-Maria, WENBIN LIU, STIVERS, David, BAGGERLY, Keith, CAREY, Mark, LLUCH, Ana, MONTEAGUDO, Carlos, XIAPING HE, WEIGMAN, Victor, CHENG FAN, PALAZZO, Juan, STEMKE-HALE, Katherine, HORTOBAGYI, Gabriel N, NOLDEN, Laura K, WANG, Nicholas J, VALERO, Vicente, GRAY, Joe W, PEROU, Charles M, MILLS, Gordon B, GILCREASE, Michael Z, KRISHNAMURTHY, Savitri, LEE, Ju-Seog, FRIDLYAND, Jane, SAHIN, Aysegul, AGARWAL, Roshan, JOY, Corwin

“…Metaplastic breast cancers (MBC) are aggressive, chemoresistant tumors characterized by lineage plasticity. To advance understanding of their pathogenesis and…”
Get full text