Search Results - "Bagg, Eleanor A"

Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO) by Aik, WeiShen, Demetriades, Marina, Hamdan, Muhammad K. K, Bagg, Eleanor. A. L, Yeoh, Kar Kheng, Lejeune, Clarisse, Zhang, Zhihong, McDonough, Michael A, Schofield, Christopher J

“…The fat mass and obesity associated protein (FTO) is a potential target for anti-obesity medicines. FTO is a 2-oxoglutarate (2OG)-dependent N-methyl nucleic…”
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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases by Chowdhury, Rasheduzzaman, Yeoh, Kar Kheng, Tian, Ya-Min, Hillringhaus, Lars, Bagg, Eleanor A, Rose, Nathan R, Leung, Ivanhoe K H, Li, Xuan S, Woon, Esther C Y, Yang, Ming, McDonough, Michael A, King, Oliver N, Clifton, Ian J, Klose, Robert J, Claridge, Timothy D W, Ratcliffe, Peter J, Schofield, Christopher J, Kawamura, Akane

“…Mutations in isocitrate dehydrogenases (IDHs) have a gain‐of‐function effect leading to R (−)‐2‐hydroxyglutarate ( R‐ 2HG) accumulation. By using biochemical,…”
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A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene by Church, Chris, Lee, Sheena, Bagg, Eleanor A L, McTaggart, James S, Deacon, Robert, Gerken, Thomas, Lee, Angela, Moir, Lee, Mecinović, Jasmin, Quwailid, Mohamed M, Schofield, Christopher J, Ashcroft, Frances M, Cox, Roger D

“…Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether…”
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Emulsion PCR Significantly Improves Nonequilibrium Capillary Electrophoresis of Equilibrium Mixtures-Based Aptamer Selection: Allowing for Efficient and Rapid Selection of Aptamer to Unmodified ABH2 Protein by Yufa, Roman, Krylova, Svetlana M, Bruce, Christine, Bagg, Eleanor A, Schofield, Christopher J, Krylov, Sergey N

“…Nonequilibrium capillary electrophoresis of equilibrium mixtures (NECEEM), a homogeneous approach to select DNA aptamers, is among the most efficient…”
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Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6 by Mantri, Monica, Krojer, Tobias, Bagg, Eleanor A., Webby, Celia J., Butler, Danica S., Kochan, Grazyna, Kavanagh, Kathryn L., Oppermann, Udo, McDonough, Michael A., Schofield, Christopher J.

“…Lysyl and prolyl hydroxylations are well-known post-translational modifications to animal and plant proteins with extracellular roles. More recent work has…”
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Dynamic Combinatorial Mass Spectrometry Leads to Inhibitors of a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase by Woon, Esther C. Y, Demetriades, Marina, Bagg, Eleanor A. L, Aik, WeiShen, Krylova, Svetlana M, Ma, Jerome H. Y, Chan, MunChiang, Walport, Louise J, Wegman, David W, Dack, Kevin N, McDonough, Michael A, Krylov, Sergey N, Schofield, Christopher J

“…2-Oxoglutarate-dependent nucleic acid demethylases are of biological interest because of their roles in nucleic acid repair and modification. Although some of…”
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Specificity of localization and phosphotransfer in the CheA proteins of Rhodobacter sphaeroides by Scott, Kathryn A, Porter, Steven L, Bagg, Eleanor A.L, Hamer, Rebecca, Hill, Jennifer L, Wilkinson, David A, Armitage, Judith P

“…Specificity of protein-protein interactions plays a vital role in signal transduction. The chemosensory pathway of Rhodobacter sphaeroides comprises multiple…”
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Kinetic Rationale for Selectivity toward N- and C-terminal Oxygen-dependent Degradation Domain Substrates Mediated by a Loop Region of Hypoxia-Inducible Factor Prolyl Hydroxylases by Flashman, Emily, Bagg, Eleanor A.L., Chowdhury, Rasheduzzaman, Mecinović, Jasmin, Loenarz, Christoph, McDonough, Michael A., Hewitson, Kirsty S., Schofield, Christopher J.

“…Hydroxylation of two conserved prolyl residues in the N- and C-terminal oxygen-dependent degradation domains (NODD and CODD) of the α-subunit of…”
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DNA aptamers for as analytical tools for the quantitative analysis of DNA-dealkylating enzymes by Krylova, Svetlana M., Karkhanina, Anna A., Musheev, Michael U., Bagg, Eleanor A.L., Schofield, Christopher J., Krylov, Sergey N.

“…The AlkB family of oxygenases catalyze the removal of alkyl groups from nucleic acid substrates in an iron and 2-oxoglutarate-dependent manner and have roles…”
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Performance evaluation of Sanger sequencing for the diagnosis of primary hyperoxaluria and comparison with targeted next generation sequencing by Williams, Emma L., Bagg, Eleanor A. L., Mueller, Michael, Vandrovcova, Jana, Aitman, Timothy J., Rumsby, Gill

“…Definitive diagnosis of primary hyperoxaluria (PH) currently utilizes sequential Sanger sequencing of the AGXT, GRPHR, and HOGA1 genes but efficacy is…”
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Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6 by Mantri, Monica, Krojer, Tobias, Bagg, Eleanor A, Webby, Celia A, Butler, Danica S, Kochan, Grazyna, Kavanagh, Kathryn L, Oppermann, Udo, McDonough, Michael A, Schofield, Christopher J

“…Lysyl and prolyl hydroxylations are well-known post-translational modifications to animal and plant proteins with extracellular roles. More recent work has…”
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A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene: e1000599 by Church, Chris, Lee, Sheena, Bagg, Eleanor AL, McTaggart, James S, Deacon, Robert, Gerken, Thomas, Lee, Angela, Moir, Lee, Mecinovic, Jasmin, Quwailid, Mohamed M, Schofield, Christopher J, Ashcroft, Frances M, Cox, Roger D

“…Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether…”
Get full text