Search Results - "Baeyens, Jose M."

Sigma‐1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury by Bravo‐Caparrós, Inmaculada, Ruiz‐Cantero, M. Carmen, Perazzoli, Gloria, Cronin, Shane J. F., Vela, José M., Hamed, Mohamed F., Penninger, Josef M., Baeyens, José M., Cobos, Enrique J., Nieto, Francisco R.

“…Neuron‐immune interaction in the dorsal root ganglia (DRG) plays a pivotal role in the neuropathic pain development after nerve injury. Sigma‐1 receptor…”
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Paclitaxel antitumor effect improvement in lung cancer and prevention of the painful neuropathy using large pegylated cationic liposomes by Jiménez-López, Julia, Bravo-Caparrós, Inmaculada, Cabeza, Laura, Nieto, Francisco R., Ortiz, Raúl, Perazzoli, Gloria, Fernández-Segura, Eduardo, Cañizares, Francisco J., Baeyens, José M., Melguizo, Consolación, Prados, José

“…[Display omitted] •Large and small liposomes (MLV and SUV) improve PTX efficacy in lung cancer cells.•Both, MLV and SUV, improve PTX antitumor activity in…”
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σ1 Receptors Are Involved in the Visceral Pain Induced by Intracolonic Administration of Capsaicin in Mice by GONZALEZ-CANO, Rafael, MERLOS, Manuel, BAEYENS, Jose M, CENDAN, Cruz M

“…Visceral pain is an important and prevalent clinical condition whose treatment is challenging. Sigma-1 (σ1) receptors modulate somatic pain, but their…”
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Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors by Ruiz-Cantero, M. Carmen, Huerta, Miguel Á., Tejada, Miguel Á., Santos-Caballero, Miriam, Fernández-Segura, Eduardo, Cañizares, Francisco J., Entrena, José M., Baeyens, José M., Cobos, Enrique J.

“…The analgesic effects of sigma-1 antagonists are undisputed, but the effects of sigma-1 agonists on pain are not well studied. Here, we used a mouse model to…”
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The sigma‐1 receptor curtails endogenous opioid analgesia during sensitization of TRPV1 nociceptors by Ruiz‐Cantero, M. Carmen, Cortés‐Montero, Elsa, Jain, Aakanksha, Montilla‐García, Ángeles, Bravo‐Caparrós, Inmaculada, Shim, Jaehoon, Sánchez‐Blázquez, Pilar, Woolf, Clifford J., Baeyens, José M., Cobos, Enrique J.

“…Background and Purpose Peripheral sensitization contributes to pathological pain. While prostaglandin E2 (PGE2) and nerve growth factor (NGF) sensitize…”
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Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice by Tejada, Miguel A., Montilla-García, Angeles, Cronin, Shane J., Cikes, Domagoj, Sánchez-Fernández, Cristina, González-Cano, Rafael, Ruiz-Cantero, M. Carmen, Penninger, Josef M., Vela, José M., Baeyens, José M., Cobos, Enrique J.

“…Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced…”
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Intracolonic Mustard Oil Induces Visceral Pain in Mice by TRPA1-Dependent and -Independent Mechanisms: Role of Tissue Injury and P2X Receptors by Gonzalez-Cano, Rafael, Montilla-García, Ángeles, Perazzoli, Gloria, Torres, Jesús M, Cañizares, Francisco J, Fernández-Segura, Eduardo, Costigan, Michael, Baeyens, José M, Cobos, Enrique J

“…Both TRPA1 and purinergic P2X receptors have been proposed as potential targets for the treatment of visceral pain. We found that the intracolonic…”
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Irreversible blockade of sigma-1 receptors by haloperidol and its metabolites in guinea pig brain and SH-SY5Y human neuroblastoma cells by Cobos, Enrique J, Pozo, Esperanza del, Baeyens, José M

“…We evaluated the effect of haloperidol (HP) and its metabolites on [³H](+)-pentazocine binding to σ₁ receptors in SH-SY5Y human neuroblastoma cells and guinea…”
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Evaluation of poly (lactic-co-glycolic acid) nanoparticles to improve the therapeutic efficacy of paclitaxel in breast cancer by Cabeza, Laura, El-Hammadi, Mazen M., Ortiz, Raul, Cayero-Otero, Maria D., Jiménez-López, Julia, Perazzoli, Gloria, Martin-Banderas, Lucia, Baeyens, Jose M., Melguizo, Consolación, Prados, Jose

“…Introduction: Paclitaxel (PTX) is a cornerstone in the treatment of breast cancer, the most common type of cancer in women. However, this drug has serious…”
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Changes in morphine-induced activation of cerebral Na+,K+-ATPase during morphine tolerance: Biochemical and behavioral consequences by Gonzalez, Luis G., Masocha, Willias, Sánchez-Fernández, Cristina, Agil, Ahmad, Ocaña, Maria, Del Pozo, Esperanza, Baeyens, José M.

“…There is ample evidence of the biological changes produced by the sustained activation of opioid receptors. We evaluated the adaptive changes of cerebral…”
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Sigma-1 receptors do not regulate calcium influx through voltage-dependent calcium channels in mouse brain synaptosomes by González, Luis G., Sánchez-Fernández, Cristina, Cobos, Enrique J., Baeyens, José M., del Pozo, Esperanza

“…Several lines of evidence suggest that σ1 receptors regulate intracellular calcium concentration [Ca2+]i. However, no previous studies have demonstrated a…”
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A novel nanoformulation of PLGA with high non-ionic surfactant content improves in vitro and in vivo PTX activity against lung cancer by Jiménez-López, Julia, El-Hammadi, Mazen M., Ortiz, Raul, Cayero-Otero, Maria D., Cabeza, Laura, Perazzoli, Gloria, Martin-Banderas, Lucia, Baeyens, Jose M., Prados, Jose, Melguizo, Consolación

“…[Display omitted] Paclitaxel (PTX), a chemotherapy agent widely used to treat lung cancer, is characterised by high toxicity, low bioavailability and the need…”
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Modality-specific peripheral antinociceptive effects of μ-opioid agonists on heat and mechanical stimuli: Contribution of sigma-1 receptors by Montilla-García, Ángeles, Perazzoli, Gloria, Tejada, Miguel Á., González-Cano, Rafael, Sánchez-Fernández, Cristina, Cobos, Enrique J., Baeyens, José M.

“…Morphine induces peripherally μ-opioid-mediated antinociception to heat but not to mechanical stimulation. Peripheral sigma-1 receptors tonically inhibit…”
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Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study by Ruiz-Cantero, M. Carmen, Entrena, José M., Artacho-Cordón, Antonia, Huerta, Miguel Á., Portillo-Salido, Enrique, Nieto, Francisco R., Baeyens, José M., Costigan, Michael, González-Cano, Rafael, Cobos, Enrique J.

“…The mechanisms for neuropathic pain amelioration by sigma-1 receptor inhibition are not fully understood. We studied genome-wide transcriptomic changes…”
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Urinary bladder sigma-1 receptors: A new target for cystitis treatment by González-Cano, Rafael, Artacho-Cordón, Antonia, Romero, Lucía, Tejada, Miguel A., Nieto, Francisco R., Merlos, Manuel, Cañizares, Francisco J., Cendán, Cruz M., Fernández-Segura, Eduardo, Baeyens, José M.

“…[Display omitted] No adequate treatment is available for painful urinary bladder disorders such as interstitial cystitis/bladder pain syndrome, and the…”
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Genetic Inactivation and Pharmacological Blockade of Sigma-1 Receptors Prevent Paclitaxel-Induced Sensory-Nerve Mitochondrial Abnormalities and Neuropathic Pain in Mice by Nieto, Francisco R, Cendán, Cruz M, Cañizares, Francisco J, Cubero, María A, Vela, José M, Fernández-Segura, Eduardo, Baeyens, José M

“…Background: Paclitaxel, a widely-used antineoplastic drug, produces a painful peripheral neuropathy that in rodents is associated with peripheral-nerve…”
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Paclitaxel-loaded hollow-poly(4-vinylpyridine) nanoparticles enhance drug chemotherapeutic efficacy in lung and breast cancer cell lines by Contreras-Cáceres, Rafael, Leiva, María C., Ortiz, Raúl, Díaz, Amelia, Perazzoli, Gloria, Casado-Rodríguez, Miguel A., Melguizo, Consolación, Baeyens, Jose M., López-Romero, Juan M., Prados, Jose

“…Paclitaxel (PTX), one of the most effective cytotoxins for the treatment of breast and lung cancer, is limited by its severe side effects and low tumor…”
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Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors by Entrena, José M., Cobos, Enrique J., Nieto, Francisco R., Cendán, Cruz M., Baeyens, José M., Del Pozo, Esperanza

“…Rationale We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain…”
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Phenytoin differentially modulates the affinity of agonist and antagonist ligands for sigma 1 receptors of guinea pig brain by Cobos, Enrique J, Baeyens, José M, Del Pozo, Esperanza

“…We evaluated the effects of phenytoin (DPH) on the affinity for sigma-1 (sigma(1)) receptors of agonist or antagonist sigma(1) ligands in guinea pig brain…”
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Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States by Pitcher, Mark H, Gonzalez-Cano, Rafael, Vincent, Kathleen, Lehmann, Michael, Cobos, Enrique J, Coderre, Terence J, Baeyens, José M, Cervero, Fernando

“…Visceral pain has a greater emotional component than somatic pain. To determine if the stress-induced analgesic response is differentially expressed in…”
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