Search Results - "Baeuerle, P.A."

H2O2 and antioxidants have opposite effects on activation of NF‐kappa B and AP‐1 in intact cells: AP‐1 as secondary antioxidant‐responsive factor by Meyer, M., Schreck, R., Baeuerle, P.A.

“…We show that AP‐1 is an antioxidant‐responsive transcription factor. DNA binding and transactivation by AP‐1 were induced in HeLa cells upon treatment with the…”
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Phosphorylation of human I kappa B‐alpha on serines 32 and 36 controls I kappa B‐alpha proteolysis and NF‐kappa B activation in response to diverse stimuli by Traenckner, E.B., Pahl, H.L., Henkel, T., Schmidt, K.N., Wilk, S., Baeuerle, P.A.

“…Post‐translational activation of the higher eukaryotic transcription factor NF‐kappa B requires both phosphorylation and proteolytic degradation of the…”
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A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF‐kappa B by Pahl, H.L., Baeuerle, P.A.

“…The inducible, higher eukaryotic transcription factor NF‐kappa B is activated by a variety of external stimuli including inflammatory cytokines, viral and…”
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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1 by Schreck, R., Rieber, P., Baeuerle, P.A.

“…Hydrogen peroxide and oxygen radicals are agents commonly produced during inflammatory processes. In this study, we show that micromolar concentrations of H2O2…”
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The p65 subunit is responsible for the strong transcription activating potential of NF‐kappa B by Schmitz, M.L., Baeuerle, P.A.

“…The nuclear form of the NF‐kappa B transcription factor binds to DNA as a heterodimer of a 50 kDa (p50) and 65 kDa (p65) polypeptide. The two polypeptides are…”
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Nuclear uptake control of NF‐kappa B by MAD‐3, an I kappa B protein present in the nucleus by Zabel, U., Henkel, T., Silva, M.S., Baeuerle, P.A.

“…I kappa B proteins specifically inhibit the DNA binding of NF‐kappa B/Rel transcription factors. An additional role as inhibitors of nuclear uptake was…”
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NF‐kappa B contacts DNA by a heterodimer of the p50 and p65 subunit by Urban, M.B., Schreck, R., Baeuerle, P.A.

“…We recently reported that the apparently non‐DNA‐binding 65 kd subunit (p65) of the NF‐kappa B transcription factor can modulate the DNA‐binding specificity of…”
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A novel complex between the p65 subunit of NF‐kappa B and c‐Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene by Hansen, S.K., Nerlov, C., Zabel, U., Verde, P., Johnsen, M., Baeuerle, P.A., Blasi, F.

“…The NF‐kappa B subunits, p50 and p65, have extensive sequence homology with the c‐rel proto‐oncogene and the Drosophila morphogen dorsal. It has recently been…”
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T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct by Aigner, M, Feulner, J, Schaffer, S, Kischel, R, Kufer, P, Schneider, K, Henn, A, Rattel, B, Friedrich, M, Baeuerle, P A, Mackensen, A, Krause, S W

“…Patients with acute myelogenous leukemia (AML) are in high need of novel targeted therapies. Here we explored the ex vivo activity of AMG330, a novel…”
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The primary structure of bovine chromogranin A: a representative of a class of acidic secretory proteins common to a variety of peptidergic cells by Benedum, U.M., Baeuerle, P.A., Konecki, D.S., Frank, R., Powell, J., Mallet, J., Huttner, W.B.

“…We have determined the primary structure of bovine chromogranin A as a first step in the elucidation of the function of this widespread protein. After…”
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BiTEs: bispecific antibody constructs with unique anti-tumor activity by Wolf, Evelyn, Hofmeister, Robert, Kufer, Peter, Schlereth, Bernd, Baeuerle, Patrick A.

“…Many new cancer therapies under development are trying to elicit specific T-cell responses against tumor cells. BiTE, a new class of bispecific antibodies, is…”
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A revival of bispecific antibodies by Kufer, Peter, Lutterbüse, Ralf, Baeuerle, Patrick A.

“…Bispecific antibodies usually do not occur in nature but are constructed by recombinant DNA or cell-fusion technologies. Most are designed to recruit cytotoxic…”
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Phase IB study of the EpCAM antibody adecatumumab combined with docetaxel in patients with EpCAM-positive relapsed or refractory advanced-stage breast cancer by Schmidt, M., Rüttinger, D., Sebastian, M., Hanusch, C.A., Marschner, N., Baeuerle, P.A., Wolf, A., Göppel, G., Oruzio, D., Schlimok, G., Steger, G.G., Wolf, C., Eiermann, W., Lang, A., Schuler, M.

“…Targeted therapy options in HER2-negative breast cancer are limited. This open-label, multicenter phase IB dose-escalation trial was conducted to determine…”
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A proteasome inhibitor prevents activation of NF‐kappa B and stabilizes a newly phosphorylated form of I kappa B‐alpha that is still bound to NF‐kappa B by Traenckner, E.B., Wilk, S., Baeuerle, P.A.

“…Activation of the inducible transcription factor NF‐kappa B involves removal of the inhibitory subunit I kappa B‐alpha from a latent cytoplasmic complex. It…”
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Hepatitis B virus transactivator MHBst: activation of NF‐kappa B, selective inhibition by antioxidants and integral membrane localization by Meyer, M., Caselmann, W.H., Schlüter, V., Schreck, R., Hofschneider, P.H., Baeuerle, P.A.

“…C‐terminal truncation of the middle surface antigen from hepatitis B virus (MHBs) gives rise to a novel transactivating protein, called MHBst. In this study we…”
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Nuclear import-export: in search of signals and mechanisms by Nigg, E A, Baeuerle, P A, Lührmann, R

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Highly efficient T cell stimulation by targeting of HCV-epitope antibody conjugates to antigen-presenting cells by Diepolder, H.M., Mende, I., de Baey, A., Baeuerle, P.A.

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224 POSTER Characterization of a murine EpCAM/CD3-bispecific BiTE molecule as a surrogate for preclinical development of the human EpCAM/CD3-bispecific BiTE molecule MT110 by Schlereth, B., Brischwein, K., Lutterbuese, P., Parr, L., Lorenczewski, G., Aman, M., Kischel, R., Kufer, P., Locher, M., Baeuerle, P.A.

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200 POSTER Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BITE class by Brischwein, K., Parr, L., Pflanz, S., Volkland, J., Lumsden, J., Klinger, M., Schlereth, B., Locher, M., Kufer, P., Baeuerle, P.A.

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Tyrosine Sulfation Is a trans-Golgi-Specific Protein Modification by Baeuerle, Patrick A., Huttner, Wieland B.

“…The trans-Golgi has been recognized as having a key role in terminal glycosylation and sorting of proteins. Here we show that tyrosine sulfation, a frequent…”
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