Search Results - "Baetselier, Patrick"

Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression by Laoui, Damya, Van Overmeire, Eva, De Baetselier, Patrick, Van Ginderachter, Jo A, Raes, Geert

“…The current review article describes the functional relationship between tumor-associated macrophages (TAM) as key cellular contributors to cancer malignancy…”
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Myeloid‐derived suppressor cells in parasitic infections by Van Ginderachter, Jo A, Beschin, Alain, De Baetselier, Patrick, Raes, Geert

“…Myeloid‐derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that share a common property of suppressing immune responses…”
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Targeting the tsetse-trypanosome interplay using genetically engineered Sodalis glossinidius by De Vooght, Linda, De Ridder, Karin, Hussain, Shahid, Stijlemans, Benoît, De Baetselier, Patrick, Caljon, Guy, Van Den Abbeele, Jan

“…Sodalis glossinidius, a secondary bacterial symbiont of the tsetse fly, is currently considered as a potential delivery system for anti-trypanosomal components…”
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MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis by Stijlemans, Benoît, Brys, Lea, Korf, Hannelie, Bieniasz-Krzywiec, Pawel, Sparkes, Amanda, Vansintjan, Liese, Leng, Lin, Vanbekbergen, Nele, Mazzone, Massimiliano, Caljon, Guy, Van Den Abbeele, Jan, Odongo, Steven, De Trez, Carl, Magez, Stefan, Van Ginderachter, Jo A, Beschin, Alain, Bucala, Richard, De Baetselier, Patrick

“…Animal African trypanosomosis is a major threat to the economic development and human health in sub-Saharan Africa. Trypanosoma congolense infections represent…”
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Trypanosoma brucei modifies the tsetse salivary composition, altering the fly feeding behavior that favors parasite transmission by Van Den Abbeele, Jan, Caljon, Guy, De Ridder, Karin, De Baetselier, Patrick, Coosemans, Marc

“…Tsetse flies are the notorious transmitters of African trypanosomiasis, a disease caused by the Trypanosoma parasite that affects humans and livestock on the…”
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Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages by Morias, Yannick, Abels, Chloé, Laoui, Damya, Van Overmeire, Eva, Guilliams, Martin, Schouppe, Elio, Tacke, Frank, deVries, Carlie J, De Baetselier, Patrick, Beschin, Alain

“…Monocytes consist of two well-defined subsets, the Ly6C+ and Ly6C- monocytes. Both CD11b+ myeloid cells populations have been proposed to infiltrate tissues…”
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High affinity nanobodies against the Trypanosome brucei VSG are potent trypanolytic agents that block endocytosis by Stijlemans, Benoît, Caljon, Guy, Natesan, Senthil Kumar A, Saerens, Dirk, Conrath, Katja, Pérez-Morga, David, Skepper, Jeremy N, Nikolaou, Alexandros, Brys, Lea, Pays, Etienne, Magez, Stefan, Field, Mark C, De Baetselier, Patrick, Muyldermans, Serge

“…The African trypanosome Trypanosoma brucei, which persists within the bloodstream of the mammalian host, has evolved potent mechanisms for immune evasion…”
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Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis by Stijlemans, Benoit, Cnops, Jennifer, Naniima, Peter, Vaast, Axel, Bockstal, Viki, De Baetselier, Patrick, Magez, Stefan

“…Extracellular trypanosomes can cause a wide range of diseases and pathological complications in a broad range of mammalian hosts. One common feature of…”
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Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells by Scott, Charlotte L., Zheng, Fang, De Baetselier, Patrick, Martens, Liesbet, Saeys, Yvan, De Prijck, Sofie, Lippens, Saskia, Abels, Chloé, Schoonooghe, Steve, Raes, Geert, Devoogdt, Nick, Lambrecht, Bart N., Beschin, Alain, Guilliams, Martin

“…Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also…”
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The transduction pattern of IL‐12‐encoding lentiviral vectors shapes the immunological outcome by Goyvaerts, Cleo, Broos, Katrijn, Escors, David, Heirman, Carlo, Raes, Geert, Baetselier, Patrick, Thielemans, Kris, Breckpot, Karine

“…In situ modification of antigen‐presenting cells garnered interest in cancer immunotherapy. Therefore, we developed APC‐targeted lentiviral vectors (LVs)…”
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Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas by Gassen, Naomi, Overmeire, Eva, Leuckx, Gunter, Heremans, Yves, Groef, Sofie, Cai, Ying, Elkrim, Yvon, Gysemans, Conny, Stijlemans, Benoît, Casteele, Mark, Baetselier, Patrick, Leu, Nico, Heimberg, Harry, Ginderachter, Jo A.

“…Pancreas injury by partial duct ligation (PDL) activates a healing response, encompassing β‐cell neogenesis and proliferation. Macrophages (MΦs) were recently…”
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MIF contributes to Trypanosoma brucei associated immunopathogenicity development by Stijlemans, Benoît, Leng, Lin, Brys, Lea, Sparkes, Amanda, Vansintjan, Liese, Caljon, Guy, Raes, Geert, Van Den Abbeele, Jan, Van Ginderachter, Jo A, Beschin, Alain, Bucala, Richard, De Baetselier, Patrick

“…African trypanosomiasis is a chronic debilitating disease affecting the health and economic well-being of many people in developing countries. The…”
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Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis by Stijlemans, Benoit, De Baetselier, Patrick, Caljon, Guy, Van Den Abbeele, Jan, Van Ginderachter, Jo A, Magez, Stefan

“…African trypanosomes are strictly extracellular protozoan parasites that cause diseases in humans and livestock and significantly affect the economic…”
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Instruction of myeloid cells by the tumor microenvironment: Open questions on the dynamics and plasticity of different tumor-associated myeloid cell populations by Schouppe, Elio, De Baetselier, Patrick, Van Ginderachter, Jo A., Sarukhan, Adelaida

“…The versatility and plasticity of myeloid cell polarization/differentiation has turned out to be crucial in health and disease, and has become the subject of…”
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Targeting of Human Antigen-Presenting Cell Subsets by Goyvaerts, Cleo, Dingemans, Jozef, De Groeve, Kurt, Heirman, Carlo, Van Gulck, Ellen, Vanham, Guido, De Baetselier, Patrick, Thielemans, Kris, Raes, Geert, Breckpot, Karine

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice by Magez, Stefan, Schwegmann, Anita, Atkinson, Robert, Claes, Filip, Drennan, Michael, De Baetselier, Patrick, Brombacher, Frank

“…African trypanosomes are extracellular parasitic protozoa, predominantly transmitted by the bite of the haematophagic tsetse fly. The main mechanism considered…”
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M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment by Van Overmeire, Eva, Stijlemans, Benoît, Heymann, Felix, Keirsse, Jiri, Morias, Yannick, Elkrim, Yvon, Brys, Lea, Abels, Chloé, Lahmar, Qods, Ergen, Can, Vereecke, Lars, Tacke, Frank, De Baetselier, Patrick, Van Ginderachter, Jo A, Laoui, Damya

“…Tumors contain a heterogeneous myeloid fraction comprised of discrete MHC-II(hi) and MHC-II(lo) tumor-associated macrophage (TAM) subpopulations that originate…”
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The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity by Laoui, Damya, Keirsse, Jiri, Morias, Yannick, Van Overmeire, Eva, Geeraerts, Xenia, Elkrim, Yvon, Kiss, Mate, Bolli, Evangelia, Lahmar, Qods, Sichien, Dorine, Serneels, Jens, Scott, Charlotte L., Boon, Louis, De Baetselier, Patrick, Mazzone, Massimiliano, Guilliams, Martin, Van Ginderachter, Jo A.

“…Various steady state and inflamed tissues have been shown to contain a heterogeneous DC population consisting of developmentally distinct subsets, including…”
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A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity by De Muylder, Géraldine, Daulouède, Sylvie, Lecordier, Laurence, Uzureau, Pierrick, Morias, Yannick, Van Den Abbeele, Jan, Caljon, Guy, Hérin, Michel, Holzmuller, Philippe, Semballa, Silla, Courtois, Pierrette, Vanhamme, Luc, Stijlemans, Benoît, De Baetselier, Patrick, Barrett, Michael P, Barlow, Jillian L, McKenzie, Andrew N J, Barron, Luke, Wynn, Thomas A, Beschin, Alain, Vincendeau, Philippe, Pays, Etienne

“…In order to promote infection, the blood-borne parasite Trypanosoma brucei releases factors that upregulate arginase expression and activity in myeloid cells…”
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The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages by Scott, Charlotte L., T’Jonck, Wouter, Martens, Liesbet, Todorov, Helena, Sichien, Dorine, Soen, Bieke, Bonnardel, Johnny, De Prijck, Sofie, Vandamme, Niels, Cannoodt, Robrecht, Saelens, Wouter, Vanneste, Bavo, Toussaint, Wendy, De Bleser, Pieter, Takahashi, Nozomi, Vandenabeele, Peter, Henri, Sandrine, Pridans, Clare, Hume, David A., Lambrecht, Bart N., De Baetselier, Patrick, Milling, Simon W.F., Van Ginderachter, Jo A., Malissen, Bernard, Berx, Geert, Beschin, Alain, Saeys, Yvan, Guilliams, Martin

“…Heterogeneity between different macrophage populations has become a defining feature of this lineage. However, the conserved factors defining macrophages…”
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