Search Results - "Baetge, E"

Efficient differentiation of human embryonic stem cells to definitive endoderm by Baetge, Emmanuel E, D'Amour, Kevin A, Agulnick, Alan D, Eliazer, Susan, Kelly, Olivia G, Kroon, Evert

“…The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use…”
Get full text

A scalable system for production of functional pancreatic progenitors from human embryonic stem cells by Schulz, Thomas C, Young, Holly Y, Agulnick, Alan D, Babin, M Josephine, Baetge, Emmanuel E, Bang, Anne G, Bhoumik, Anindita, Cepa, Igor, Cesario, Rosemary M, Haakmeester, Carl, Kadoya, Kuniko, Kelly, Jonathan R, Kerr, Justin, Martinson, Laura A, McLean, Amanda B, Moorman, Mark A, Payne, Janice K, Richardson, Mike, Ross, Kelly G, Sherrer, Eric S, Song, Xuehong, Wilson, Alistair Z, Brandon, Eugene P, Green, Chad E, Kroon, Evert J, Kelly, Olivia G, D'Amour, Kevin A, Robins, Allan J

“…Development of a human embryonic stem cell (hESC)-based therapy for type 1 diabetes will require the translation of proof-of-principle concepts into a…”
Get full text

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo by Richardson, Mike, Young, Holly, Kadoya, Kuniko, Baetge, Emmanuel E, Kelly, Olivia G, Carpenter, Melissa K, Smart, Nora G, Bang, Anne G, Eliazer, Susan, D'Amour, Kevin A, Agulnick, Alan D, Kroon, Evert, Martinson, Laura A, Cunningham, Justine

“…Development of a cell therapy for diabetes would be greatly aided by a renewable supply of human β-cells. Here we show that pancreatic endoderm derived from…”
Get full text

Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells by Baetge, Emmanuel E, D'Amour, Kevin A, Bang, Anne G, Eliazer, Susan, Kelly, Olivia G, Agulnick, Alan D, Smart, Nora G, Moorman, Mark A, Kroon, Evert, Carpenter, Melissa K

“…Of paramount importance for the development of cell therapies to treat diabetes is the production of sufficient numbers of pancreatic endocrine cells that…”
Get full text

Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells by Kelly, Olivia G, Chan, Man Yin, Martinson, Laura A, Kadoya, Kuniko, Ostertag, Traci M, Ross, Kelly G, Richardson, Mike, Carpenter, Melissa K, D'Amour, Kevin A, Kroon, Evert, Moorman, Mark, Baetge, Emmanuel E, Bang, Anne G

“…Kelly et al . describe antibodies for purifying two progenitor populations that arise during the differentiation of human embryonic stem cells to pancreatic…”
Get full text

Tolerance Induction and Reversal of Diabetes in Mice Transplanted with Human Embryonic Stem Cell-Derived Pancreatic Endoderm by Szot, Gregory L., Yadav, Mahesh, Lang, Jiena, Kroon, Evert, Kerr, Justin, Kadoya, Kuniko, Brandon, Eugene P., Baetge, Emmanuel E., Bour-Jordan, Hélène, Bluestone, Jeffrey A.

“…Type 1 diabetes (T1D) is an autoimmune disease caused by T cell-mediated destruction of insulin-producing β cells in the islets of Langerhans. In most cases,…”
Get full text

Activin A Efficiently Specifies Definitive Endoderm from Human Embryonic Stem Cells Only When Phosphatidylinositol 3‐Kinase Signaling Is Suppressed by McLean, Amanda B., D'Amour, Kevin A., Jones, Karen L., Krishnamoorthy, Malini, Kulik, Michael J., Reynolds, David M., Sheppard, Alan M., Liu, Huiqing, Xu, Ying, Baetge, Emmanuel E., Dalton, Stephen

“…Human ESCs (hESCs) respond to signals that determine their pluripotency, proliferation, survival, and differentiation status. In this report, we demonstrate…”
Get full text

Production of β-cells from human embryonic stem cells by Baetge, E. E.

“…The making of functional pancreatic islets in renewable numbers has been a goal of stem cell biologists since early 2000. Since that time, many studies have…”
Get full text

X‐Inactivation Status Varies in Human Embryonic Stem Cell Lines by Hoffman, Lisa M., Hall, Lisa, Batten, Jennifer L., Young, Holly, Pardasani, Dheerja, Baetge, E. Edward, Lawrence, Jeanne, Carpenter, Melissa K.

“…Human embryonic stem cells (hESCs) derived from human blastocysts have an apparently unlimited proliferative capacity and can differentiate into ectoderm,…”
Get full text

Are stem cells a cure for diabetes? by McCall, Michael D, Toso, Christian, Baetge, Emmanuel E, Shapiro, A M James

“…With the already heightened demand placed on organ donation, stem cell therapy has become a tantalizing idea to provide glucose-responsive insulin-producing…”
Get more information

Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease by Emerich, Dwaine F, Winn, Shelley R, Hantraye, Philippe M, Peschanski, Marc, Chen, Er-Yun, Chu, Yaping, McDermott, Patricia, Baetge, E. Edward, Kordower, Jeffrey H

“…Huntington's disease is a genetic disorder that results from degeneration of striatal neurons, particularly those containing GABA (gamma-aminobutyric acid)…”
Get full text

Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients by Aebischer, P, Schluep, M, Déglon, N, Joseph, J M, Hirt, L, Heyd, B, Goddard, M, Hammang, J P, Zurn, A D, Kato, A C, Regli, F, Baetge, E E

“…Neuronal growth factors hold promise for providing therapeutic benefits in various neurological disorders. As a means of ensuring adequate central nervous…”
Get full text

Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones by Zurn, A D, Baetge, E E, Hammang, J P, Tan, S A, Aebischer, P

“…Glial cell line-derived neurotrophic factor (GDNF) has been postulated to be a specific dopaminergic neurotrophic factor since it selectively enhances the…”
Get more information

GDNF Reduces Drug-Induced Rotational Behavior after Medial Forebrain Bundle Transection by a Mechanism Not Involving Striatal Dopamine by Tseng, Jack L, Baetge, E. Edward, Zurn, Anne D, Aebischer, Patrick

“…Parkinson's disease (PD) is characterized by the progressive loss of the substantia nigra (SN) dopaminergic neurons projecting to the striatum. Neurotrophic…”
Get full text

The Aged Monkey Basal Forebrain: Rescue and Sprouting of Axotomized Basal Forebrain Neurons After Grafts of Encapsulated Cells Secreting Human Nerve Growth Factor by Kordower, Jeffrey H., Winn, Shelley R., Liu, Yue-Ting, Mufson, Elliott J., Sladek, John R., Hammang, Joseph P., Baetge, E. Edward, Emerich, Dwaine F.

“…Six Rhesus monkeys between 24 and 29 years of age received unilateral transections of the fornix. Three monkeys then received intraventricular transplants of…”
Get full text

Polymer-Encapsulated Cells Genetically Modified to Secrete Human Nerve Growth Factor Promote the Survival of Axotomized Septal Cholinergic Neurons by Winn, Shelley R., Hammang, Joseph P., Emerich, Dwaine F., Lee, Alice, Palmiter, Richard D., Baetge, E. Edward

“…Effective treatments for neurodegenerative disorders are limited by our inability to alter the progression of the diseases. A number of proteins have specific…”
Get full text

Implants of polymer-encapsulated human NGF-secreting cells in the nonhuman primate: rescue and sprouting of degenerating cholinergic basal forebrain neurons by Emerich, D F, Winn, S R, Harper, J, Hammang, J P, Baetge, E E, Kordower, J H

“…Baby hamster kidney (BHK) cells were genetically modified to secrete high levels of human nerve growth factor (BHK-hNGF). Following polymer encapsulation,…”
Get more information

Implantation of encapsulated catecholamine and GDNF-producing cells in rats with unilateral dopamine depletions and parkinsonian symptoms by Lindner, Mark D., Winn, Shelley R., Baetge, E.E., Hammang, Joseph P., Gentile, Frank T., Doherty, Ed, McDermott, Patricia E., Frydel, Beata, Ullman, M.David, Schallert, Timothy, Emerich, Dwaine F.

“…Studies in rodents suggest that PC12 cells, encapsulated in semipermeable ultrafiltration membranes and implanted in the striatum, have some potential efficacy…”
Get full text

Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse by Sagot, Y, Tan, S A, Baetge, E, Schmalbruch, H, Kato, A C, Aebischer, P

“…Ciliary neurotrophic factor (CNTF) has recently generated great interest due to its potential as a therapeutic agent for the treatment of human…”
Get more information

Summary on Future Horizons by Baetge, Emmanuel E

Get more information