Search Results - "Baeten, Jeremy T."

Smooth muscle cell-specific Notch1 haploinsufficiency restricts the progression of abdominal aortic aneurysm by modulating CTGF expression by Sachdeva, Jaspreet, Mahajan, Advitiya, Cheng, Jeeyun, Baeten, Jeremy T, Lilly, Brenda, Kuivaniemi, Helena, Hans, Chetan P

“…Infiltration of macrophages and apoptosis of vascular smooth muscle cells (VSMCs) promote the development of abdominal aortic aneurysm (AAA). Previously, we…”
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Genomic studies controvert the existence of the CUX1 p75 isoform by Krishnan, Manisha, Senagolage, Madhavi D., Baeten, Jeremy T., Wolfgeher, Donald J., Khan, Saira, Kron, Stephen J., McNerney, Megan E.

“…CUX1 , encoding a homeodomain-containing transcription factor, is recurrently deleted or mutated in multiple tumor types. In myeloid neoplasms, CUX1 deletion…”
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Loss of Notch2 and Notch3 in vascular smooth muscle causes patent ductus arteriosus by Baeten, Jeremy T., Jackson, Ashley R., McHugh, Kirk M., Lilly, Brenda

“…Summary The overlapping roles of the predominant Notch receptors in vascular smooth muscle cells, Notch2 and Notch3, have not been clearly defined in vivo. In…”
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The side population enriches for leukemia-propagating cell activity and Wnt pathway expression in zebrafish acute lymphoblastic leukemia by Baeten, Jeremy T, Waarts, Michael R, Pruitt, Margaret M, Chan, Wen-Ching, Andrade, Jorge, de Jong, Jill L O

“…Cancer stem cells have been strongly linked to resistance and relapse in many malignancies. However, purifying them from within the bulk tumor has been…”
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Genetic Models of Leukemia in Zebrafish by Baeten, Jeremy T, de Jong, Jill L O

“…The zebrafish animal model is gaining increasing popularity as a tool for studying human disease. Over the past 15 years, many models of leukemia and other…”
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Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells by Baeten, Jeremy T., Lilly, Brenda

“…Notch signaling is a key regulator of vascular smooth muscle cell (VSMC) phenotypes, including differentiation, proliferation, and cell survival. However, the…”
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CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions by Baeten, Jeremy T., Liu, Weihan, Preddy, Isabelle C., Zhou, Ningxuan, McNerney, Megan E.

“…Monosomy 7 and del(7q) are among the most common cytogenetic abnormalities in myeloid malignancies, yet their underlying pathogenesis remains unclear. Using an…”
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Generation of transgenic mice that conditionally express microRNA miR‐145 by Sawant, Dwitiya, Klevenow, Emilie, Baeten, Jeremy T., Thomas, Shelby, Manivannan, Sathiyanarayanan, Conway, Simon J., Lilly, Brenda

“…Summary MicroRNAs are modulators of cellular phenotypes and their functions contribute to development, homeostasis, and disease. miR‐145 is a conserved…”
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TP53 Null AML Line Does Not Selectively Expand Under Lenalidomide Treatment by Johansson, Kimberly B., Baeten, Jeremy T, Link, Daniel C.

“…Lenalidomide is an immunomodulatory therapeutic (IMiD) with known anti-proliferative and anti-angiogenic effects, and is an approved therapy for both 5q-…”
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Effects of PARP Inhibitor Therapy on p53-Deficient Hematopoietic Stem and Progenitor Cell Fitness by Baeten, Jeremy T, Chan, Irenaeus C.C., Link, Daniel C., Bolton, Kelly L.

“…▪ Poly (ADP-ribose) polymerase (PARP) inhibitors are an important new class of anti-cancer therapies. Therapy-related myeloid neoplasia (tMN) has been reported…”
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Targeting ATR in TP53-Mutant AML/MDS by Baeten, Jeremy T, Agashe, Sumedha, Quinet, Annabel, Johansson, Kimberly B., Vindigni, Alessandro, Uy, Geoffrey L., Link, Daniel C.

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Impact of PARP Inhibitor and Platinum Therapy on Clonal Hematopoiesis by Baeten, Jeremy T., Chan, Irenaeus C.C., Moukarzel, Lea, Carter, Amber C., Patel, Minal, Stopsack, Konrad H., Pharoah, Paul, Brenton, James, Li, Bob T, Abida, Wassim, Schram, Alison M., Cadoo, Karen, Weigelt, Britta, Cruchaga, Carlos, Scher, Howard, Levine, Ross L, Papaemmanuil, Elli, Link, Daniel C., Bolton, Kelly L.

“…Poly (ADP-ribose) polymerase inhibitors (PARPi) are a promising new class of targeted therapy used in a variety of solid tumors with homologous recombination…”
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Germline Homologous Recombination Deficiency (HRD) Influences the Fitness Impact of Oncologic Therapy on DNA Damage Response Gene Clonal Hematopoiesis (CH) by Baeten, Jeremy T., Chan, Irenaeus C.C., Moukarzel, Lea, Carter, Amber C., Patel, Minal, Stopsack, Konrad, Pharoah, Paul, Brenton, James, Li, Bob, Abida, Wassim, Schram, Alison, Cadoo, Karen, Weigelt, Britta, Cruchaga, Carlos, Scher, Howard, Levine, Ross, Papaemmanuil, Elli, Link, Daniel C., Bolton, Kelly L.

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AML-743 Germline Homologous Recombination Deficiency (HRD) Influences the Fitness Impact of Oncologic Therapy on DNA Damage Response Gene Clonal Hematopoiesis (CH) by Baeten, Jeremy T., Chan, Irenaeus C.C., Moukarzel, Lea, Carter, Amber C., Patel, Minal, Stopsack, Konrad, Pharoah, Paul, Brenton, James, Li, Bob, Abida, Wassim, Schram, Alison, Cadoo, Karen, Weigelt, Britta, Cruchaga, Carlos, Scher, Howard, Levine, Ross, Papaemmanuil, Elli, Link, Daniel C., Bolton, Kelly L.

“…Previous studies have linked poly(ADP-ribose) polymerase inhibitors (PARPi) and platinum-based agents to therapy-related myeloid neoplasia. However,…”
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