Search Results - "Baeten, Dominique L.P."

Killer immunoglobulin receptor genes in spondyloarthritis by Kuijpers, Taco W, Vendelbosch, Sanne, Berg, Merlijn van den, Baeten, Dominique L.P

“…PURPOSE OF REVIEWWe focus on the role of killer immunoglobulin receptor (KIR) interactions with the human leukocyte antigens (HLA)-B27 ligand and the potential…”
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Interleukin-17 and a tale of two autoimmune diseases by Baeten, Dominique L.P, Kuchroo, Vijay K

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New treatment paradigms in spondyloarthritis by van Mens, Leonieke J.J, van de Sande, Marleen G.H, Baeten, Dominique L.P

“…PURPOSE OF REVIEWThe review presents the recent rapid expansion of therapeutical options in spondyloarthritis. Additionally, it focuses on the importance of…”
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BOB.1 controls memory B-cell fate in the germinal center reaction by Levels, Maartje J., Fehres, Cynthia M., van Baarsen, Lisa G.M., van Uden, Nathalie O.P., Germar, Kristine, O'Toole, Tom G., Blijdorp, Iris C.J., Semmelink, Johanna F., Doorenspleet, Marieke E., Bakker, Arjen Q., Krasavin, Mikhail, Tomilin, Alexey, Brouard, Sophie, Spits, Hergen, Baeten, Dominique L.P., Yeremenko, Nataliya G.

“…During T cell-dependent (TD) germinal center (GC) responses, naïve B cells are instructed to differentiate towards GC B cells (GCBC), high-affinity long-lived…”
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The inflammatory function of human IgA by Hansen, Ivo S., Baeten, Dominique L. P., den Dunnen, Jeroen

“…The prevailing concept regarding the immunological function of immunoglobulin A (IgA) is that it binds to and neutralizes pathogens to prevent infection at…”
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The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium by Frey, Silke, Derer, Anja, Messbacher, Maria-Elena, Baeten, Dominique L P, Bugatti, Serena, Montecucco, Carlomaurizio, Schett, Georg, Hueber, Axel J

“…Interleukin (IL)-36α is a recently described member of the IL-1 cytokine family with pro-inflammatory and clearly pathogenic properties in psoriasis. To…”
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The IL-17A-Producing CD8+ T-Cell Population in Psoriatic Lesional Skin Comprises Mucosa-Associated Invariant T Cells and Conventional T Cells by Teunissen, Marcel B.M., Yeremenko, Nataliya G., Baeten, Dominique L.P., Chielie, Saskia, Spuls, Phyllis I., de Rie, Menno A., Lantz, Olivier, Res, Pieter C.M.

“…IL-17A is pivotal in the etiology of psoriasis, and CD8+ T cells with the ability to produce this cytokine (Tc17 cells) are over-represented in psoriatic…”
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C-Reactive Protein Promotes Inflammation through FcγR-Induced Glycolytic Reprogramming of Human Macrophages by Newling, Melissa, Sritharan, Lathees, van der Ham, Alwin J, Hoepel, Willianne, Fiechter, Renée H, de Boer, Leonie, Zaat, Sebastian A J, Bisoendial, Radjesh J, Baeten, Dominique L P, Everts, Bart, den Dunnen, Jeroen

“…C-reactive protein (CRP) is an acute-phase protein produced in high quantities by the liver in response to infection and during chronic inflammatory disorders…”
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IgG Subclasses Shape Cytokine Responses by Human Myeloid Immune Cells through Differential Metabolic Reprogramming by Hoepel, Willianne, Allahverdiyeva, Sona, Harbiye, Haneen, de Taeye, Steven W, van der Ham, Alwin J, de Boer, Leonie, Zaat, Sebastiaan A J, van Weeghel, Michel, Baeten, Dominique L P, Houtkooper, Riekelt H, Everts, Bart, Vidarsson, Gestur, den Dunnen, Jeroen

“…IgG Abs are crucial for various immune functions, including neutralization, phagocytosis, and Ab-dependent cellular cytotoxicity. In this study, we identified…”
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Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis by Kerkman, Priscilla F, Fabre, Emeline, van der Voort, Ellen I H, Zaldumbide, Arnaud, Rombouts, Yoann, Rispens, Theo, Wolbink, Gertjan, Hoeben, Rob C, Spits, Hergen, Baeten, Dominique L P, Huizinga, Tom W J, Toes, René E M, Scherer, Hans U

“…Immunity to citrullinated antigens is a hallmark of rheumatoid arthritis (RA). We set out to elucidate its biology by identifying and characterising…”
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Interleukin‐17A Is Produced by CD4+ but Not CD8+ T Cells in Synovial Fluid Following T Cell Receptor Activation and Regulates Different Inflammatory Mediators Compared to Tumor Necrosis Factor in a Model of Psoriatic Arthritis Synovitis by Xu, Xiaofei, Davelaar, Nadine, Mus, Anne‐Marie, Asmawidjaja, Patrick S., Hazes, Johanna M. W., Baeten, Dominique L. P., Vis, Marijn, Bisoendial, Radjesh J., Prens, Errol P., Lubberts, Erik

“…Objective Interleukin‐17A (IL‐17A) and tumor necrosis factor (TNF) contribute to the pathogenesis of psoriatic arthritis (PsA). However, their functional…”
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Transmembrane TNF drives osteoproliferative joint inflammation reminiscent of human spondyloarthritis by Kaaij, Merlijn H, van Tok, Melissa N, Blijdorp, Iris C, Ambarus, Carmen A, Stock, Michael, Pots, Désiree, Knaup, Véronique L, Armaka, Marietta, Christodoulou-Vafeiadou, Eleni, van Melsen, Tessa K, Masdar, Huriatul, Eskes, Harry J P P, Yeremenko, Nataliya G, Kollias, George, Schett, Georg, Tas, Sander W, van Duivenvoorde, Leonie M, Baeten, Dominique L P

“…TNF plays a key role in immune-mediated inflammatory diseases including rheumatoid arthritis (RA) and spondyloarthritis (SpA). It remains incompletely…”
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Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages by Vogelpoel, Lisa T. C., Hansen, Ivo S., Rispens, Theo, Muller, Femke J. M., van Capel, Toni M. M., Turina, Maureen C., Vos, Joost B., Baeten, Dominique L. P., Kapsenberg, Martien L., de Jong, Esther C., den Dunnen, Jeroen

“…M2 macrophages suppress inflammation in numerous disorders, including tumour formation, infection and obesity. However, the exact role of M2 macrophages in the…”
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APRIL Induces a Novel Subset of IgA + Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1 by Fehres, Cynthia M, van Uden, Nathalie O, Yeremenko, Nataliya G, Fernandez, Leticia, Franco Salinas, Gabriela, van Duivenvoorde, Leonie M, Huard, Bertrand, Morel, Jacques, Spits, Hergen, Hahne, Michael, Baeten, Dominique L P

“…Regulatory B cells (Bregs) are immunosuppressive cells that modulate immune responses through multiple mechanisms. The signals required for the differentiation…”
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Intimal lining layer macrophages but not synovial sublining macrophages display an IL-10 polarized-like phenotype in chronic synovitis by Ambarus, Carmen A, Noordenbos, Troy, de Hair, Maria J H, Tak, Paul P, Baeten, Dominique L P

“…Synovial tissue macrophages play a key role in chronic inflammatory arthritis, but the contribution of different macrophage subsets in this process remains…”
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Control of cytokine production by human fc gamma receptors: implications for pathogen defense and autoimmunity by Vogelpoel, Lisa T C, Baeten, Dominique L P, de Jong, Esther C, den Dunnen, Jeroen

“…Control of cytokine production by immune cells is pivotal for counteracting infections via orchestration of local and systemic inflammation. Although their…”
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Interleukin 17A and IL-17F Expression and Functional Responses in Rheumatoid Arthritis and Peripheral Spondyloarthritis by Chen, Sijia, Blijdorp, Iris C, van Mens, Leonieke J J, Bowcutt, Rowann, Latuhihin, Talia E, van de Sande, Marleen G H, Shaw, Stevan, Yeremenko, Nataliya G, Baeten, Dominique L P

“…Targeting the interleukin 17 (IL-17) axis is efficacious in psoriasis and spondyloarthritis (SpA), but not in rheumatoid arthritis (RA). We investigated…”
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Expansion of Interleukin‐22– and Granulocyte–Macrophage Colony‐Stimulating Factor–Expressing, but Not Interleukin‐17A–Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis by Blijdorp, Iris C. J., Menegatti, Silvia, Mens, Leonike J. J., Sande, Marleen G. H., Chen, Sijia, Hreggvidsdottir, Hulda S., Noordenbos, Troy, Latuhihin, Talia E., Bernink, Jochem H., Spits, Hergen, Rogge, Lars, Baeten, Dominique L. P., Yeremenko, Nataliya G.

“…Objective Clinical trials of the anti–interleukin‐17A (anti–IL‐17A) antibody secukinumab have demonstrated a crucial role of the cytokine IL‐17A in the…”
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Brief Report: Interleukin‐17 Blockade With Secukinumab in Peripheral Spondyloarthritis Impacts Synovial Immunopathology Without Compromising Systemic Immune Responses by Mens, Leonieke J. J., Sande, Marleen G. H., Menegatti, Silvia, Chen, Sijia, Blijdorp, Iris C. J., Jong, Henriette M., Fluri, Inka A., Latuhihin, Talia E., Kuijk, Arno W. R., Rogge, Lars, Yeremenko, Nataliya G., Baeten, Dominique L. P.

“…Objective Secukinumab (anti–interleukin‐17A [anti–IL‐17A]) is an effective therapy for ankylosing spondylitis and psoriatic arthritis, the prototypical forms…”
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C-Reactive Protein Controls IL-23 Production by Human Monocytes by Geyer, Chiara E, Newling, Melissa, Sritharan, Lathees, Griffith, Guillermo R, Chen, Hung-Jen, Baeten, Dominique L P, den Dunnen, Jeroen

“…C-reactive protein (CRP) is an acute-phase protein in humans that is produced in high quantities by the liver upon infection and under inflammatory conditions…”
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