Search Results - "Baer, Mark"

Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment by VAIL, Mary E, MURONE, Carmel, YARRANTON, Geoffrey, LLERENA, Carmen, GARIC, Slavisa, ABRAMSON, David, CARTWRIGHT, Glenn, SCOTT, Andrew M, LACKMANN, Martin, TAN, April, HII, Linda, ABEBE, Degu, JANES, Peter W, LEE, Fook-Thean, BAER, Mark, PALATH, Varghese, BEBBINGTON, Christopher

“…Eph receptor tyrosine kinases are critical for cell-cell communication during normal and oncogenic tissue patterning and tumor growth. Somatic mutation…”
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Engineered Human Antibody Fab Fragment Specific for Pseudomonas aeruginosa PcrV Antigen Has Potent Antibacterial Activity by Baer, Mark, Sawa, Teiji, Flynn, Peter, Luehrsen, Kenneth, Martinez, David, Wiener-Kronish, Jeanine P, Yarranton, Geoffrey, Bebbington, Christopher

“…Pseudomonas aeruginosa is an opportunistic pathogen that can cause acute lung injury and mortality through the delivery of exotoxins by the type III secretion…”
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The eosinophil surface receptor epidermal growth factor–like module containing mucin-like hormone receptor 1 (EMR1): A novel therapeutic target for eosinophilic disorders by Legrand, Fanny, PhD, PharmD, Tomasevic, Nenad, PhD, Simakova, Olga, PhD, Lee, Chyi-Chia Richard, MD, PhD, Wang, Zengfang, PhD, Raffeld, Mark, MD, Makiya, Michelle A., MS, Palath, Varghese, PhD, Leung, John, BS, Baer, Mark, PhD, Yarranton, Geoffrey, PhD, Maric, Irina, MD, Bebbington, Christopher, PhD, Klion, Amy D., MD

“…Background Although several novel agents are currently in clinical trials for eosinophilic disorders, none has demonstrated efficacy in reducing blood and…”
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The Highly Productive Thermothelomyces heterothallica C1 Expression System as a Host for Rapid Development of Influenza Vaccines by Keresztes, Gabor, Baer, Mark, Alfenito, Mark R, Verwoerd, Theo C, Kovalchuk, Andriy, Wiebe, Marilyn G, Andersen, Tor Kristian, Saloheimo, Markku, Tchelet, Ronen, Kensinger, Richard, Grødeland, Gunnveig, Emalfarb, Mark

“…(1) Influenza viruses constantly change and evade prior immune responses, forcing seasonal re-vaccinations with updated vaccines. Current FDA-approved vaccine…”
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Tumor Necrosis Factor Alpha Transcription in Macrophages Is Attenuated by an Autocrine Factor That Preferentially Induces NF-κB p50 by Baer, Mark, Dillner, Allan, Schwartz, Richard C., Sedon, Constance, Nedospasov, Sergei, Johnson, Peter F.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The C/EBP bZIP Domain Can Mediate Lipopolysaccharide Induction of the Proinflammatory Cytokines Interleukin-6 and Monocyte Chemoattractant Protein-1 by Hu, Hsien-Ming, Tian, Qiang, Baer, Mark, Spooner, Chauncey J., Williams, Simon C., Johnson, Peter F., Schwartz, Richard C.

“…C/EBPα, β, and δ are all expressed by bone marrow-derived macrophages. Ectopic expression of any of these transcription factors is sufficient to confer…”
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How Interactive Video Games Helped Shape the Modern Computer World by Baer, Mark W., Hui, Jason K.

“…This paper briefly describes the development of "Brown Box" interactive video game console, developed by IEEE Fellow, Masaru Ibuka Consumer Electronics Award…”
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GM-CSF–dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia by Padron, Eric, Painter, Jeffrey S., Kunigal, Sateesh, Mailloux, Adam W., McGraw, Kathy, McDaniel, Jessica M., Kim, Eunhee, Bebbington, Christopher, Baer, Mark, Yarranton, Geoffrey, Lancet, Jeffrey, Komrokji, Rami S., Abdel-Wahab, Omar, List, Alan F., Epling-Burnette, Pearlie K.

“…Granulocyte-macrophage–colony-stimulating factor (GM-CSF) hypersensitivity is a hallmark of juvenile myelomonocytic leukemia (JMML) but has not been…”
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BCL-3 and NF-κB p50 Attenuate Lipopolysaccharide-induced Inflammatory Responses in Macrophages by Wessells, Jennifer, Baer, Mark, Young, Howard A., Claudio, Estefania, Brown, Keith, Siebenlist, Ulrich, Johnson, Peter F.

“…Lipopolysaccharide (LPS) induces expression of tumor necrosis factor α (TNFα) and other pro-inflammatory cytokines in macrophages. Following its induction,…”
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'Graduate education in the humanities': a surresponse to William Pannapacker by Baer, Marc

“…Let us review where we stand: Professor Pannapacker and I agree that there is a serious problem, existing as it has for a generation. There are more students…”
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'Graduate education in the humanities': a response to William Pannapacker by Baer, Marc

“…Let me begin by thanking my colleague Bill Pannapacker for raising a number of important issues. On several of these I stand in almost complete agreement. Yet…”
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High-resolution characterization of antibody fragment/antigen interactions using Biacore T100 by Papalia, Giuseppe A., Baer, Mark, Luehrsen, Kenneth, Nordin, Helena, Flynn, Peter, Myszka, David G.

“…A Biacore T100 optical biosensor was used to characterize the binding kinetics of a panel of antigen binding fragments (Fabs) directed against the PcrV protein…”
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A high affinity recombinant antibody to the human EphA3 receptor with enhanced ADCC activity by Tomasevic, Nenad, Luehrsen, Kenneth, Baer, Mark, Palath, Varghese, Martinez, David, Williams, Jason, Yi, Christina, Sujatha-Bhaskar, Swathi, Lanke, Rohini, Leung, John, Ching, Wendy, Lee, Andreia, Bai, Lu, Yarranton, Geoffrey, Bebbington, Christopher

“…Abstract EphA3is expressed in solid tumors and leukemias and is an attractive target for the therapy. We have generated a panel of Humaneered® antibodies to…”
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Eosinophil surface receptor EMR1: a novel therapeutic target for eosinophilic disorders by Legrand, Fanny, Tomasevic, Nenad, Simakova, Olga, Lee, Chyi-Chia Richard, Wang, Zengfang, Raffeld, Mark, Makiya, Michelle A., Palath, Varghese, Leung, John, Baer, Mark, Yarranton, Geoffrey, Maric, Irina, Bebbington, Christopher, Klion, Amy D.

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GM-CSF Signaling Abnormalities in Chronic Myelomonocytic Leukemia by Padron, Eric, Painter, Jeffrey S., Mailloux, Adam W, McDaniel, Jessica M., Bebbington, Christopher, Baer, Mark, Komrokji, Rami S., List, Alan F., Epling-Burnette, Pearlie K

“…Abstract 1713 Chronic Myelomonocytic Leukemia (CMML) and Juvenile Myelomonocytic leukemia (JMML) are classified as MDS/MPN in the WHO classification system…”
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Preclinical Characterization of KB003, a Novel Humaneered™ Monoclonal Anti-GM-CSF Antibody, Demonstrates That the GM-CSF Signaling Axis Is a Therapeutic Target in Chronic Myelomonocytic Leukemia (CMML) by Padron, Eric, Painter, Jeffrey S, Mailloux, Adam W, McGraw, Kathy L., McDaniel, Jessica M., Bebbington, Christopher, Baer, Mark, Yarranton, Geoffrey, Lancet, Jeffrey E, Komrokji, Rami S., List, Alan F., Epling-Burnette, P.K.

“…Abstract 3793 Chronic Myelomonocytic Leukemia (CMML) is a genetically diverse hematologic malignancy characterized by cytopenias with or without leukocytosis,…”
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Generation of Truncated C/EBP beta Isoforms by in Vitro Proteolysis by Baer, M, Johnson, P F

“…Multiple forms of the transcriptional regulator CCAAT/enhancer-binding protein beta (C/EBP beta ) with molecular masses of approximately 38, 34, 20, and 14 kDa…”
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A Recombinant Antibody to EphA3 with Pro-Apoptotic and Enhanced ADCC Activity Against Various Hematologic Malignancies Shows Selective Inhibition of Colony Formation From Long-Term Culture-Initiating Cells (LTC-ICs) In Primary Leukemia Samples by Palath, Varghese, Vekhande, Rohini, Baer, Mark, Ching, Wendy, Tomasevic, Nenad, Martinez, David, Yi, Christina, Bhaskar, Swathi, Luehrsen, Kenneth, Williams, Jason, Leung, John, List, Alan F., Zhang, Ling, Lackmann, Martin, Boyd, Andrew, Scott, Andrew, Cilloni, Daniela, Yarranton, Geoffrey, Bebbington, Christopher

“…Abstract 2897 EphA3 is a receptor tyrosine kinase expressed at high level on the surface of some solid tumors and certain leukemias. KB004 is a high-affinity…”
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An Engineered Human Antibody Fab Fragment Specific for Pseudomonas aeruginosa PcrV Antigen Has Potent Antibacterial Activitv by BAER, Mark, SAWA, Teiji, FLYNN, Peter, LUEHRSEN, Kenneth, MARTINEZ, David, WIENER-KRONISH, Jeanine P, YARRANTON, Geoffrey, BEBBINGTON, Christopher

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Antibody to Granulocyte Macrophage Colony–stimulating Factor Reduces the Number of Activated Tissue Macrophages and Improves Left Ventricular Function After Myocardial Infarction in a Rat Coronary Artery Ligation Model by Kellar, Robert S, Lancaster, Jordan J, Thai, Hoang M, Juneman, Elizabeth, Johnson, Nicholle M, Byrne, Howard G, Stansifer, Maribeth, Arsanjani, Reza, Baer, Mark, Bebbington, Christopher, Flashner, Michael, Yarranton, Geoffrey, Goldman, Steven

“…Granulocyte macrophage colony-stimulating factor (GM-CSF) promotes infarct expansion and inappropriate collagen synthesis in a myocardial infarction (MI). This…”
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