Search Results - "Bae, You Han"

In Vivo Evaluation of Doxorubicin-Loaded Polymeric Micelles Targeting Folate Receptors and Early Endosomal pH in Drug-Resistant Ovarian Cancer by Kim, Dongin, Gao, Zhong Gao, Lee, Eun Seong, Bae, You Han

“…The second generation of pH-sensitive micelles composed of poly(l-histidine-co-l-phenlyalanine(16 mol %))(MW:5K)-b-PEG(MW:2K) and poly(l-lactic…”
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Doxorubicin Loaded pH-sensitive Micelle: Antitumoral Efficacy against Ovarian A2780/DOXR Tumor by Kim, Dongin, Lee, Eun Seong, Park, Kyeongsoon, Kwon, Ick Chan, Bae, You Han

“…Purpose To evaluate pH-sensitive mixed micelles for multidrug resistant (MDR) ovarian tumor targeting and optical imaging of solid tumors. Method Doxorubicin…”
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Perspectives on the past, present, and future of cancer nanomedicine by Youn, Yu Seok, Bae, You Han

“…The justification of cancer nanomedicine relies on enhanced permeation (EP) and retention (R) effect and the capability of intracellular targeting due…”
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Self-Organized Nanogels Responding to Tumor Extracellular pH:  pH-Dependent Drug Release and in Vitro Cytotoxicity against MCF-7 Cells by Na, Kun, Lee, Eun Seong, Bae, You Han

“…The principal objective of this study was to fabricate doxorubicin-loaded self-organized nanogels composed of hydrophobized pullulan (PUL)-N α-Boc-l-histidine…”
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Thermosensitive sol–gel reversible hydrogels by Jeong, Byeongmoon, Kim, Sung Wan, Bae, You Han

“…Aqueous polymer solutions that are transformed into gels by changes in environmental conditions, such as temperature and pH, thus resulting in in situ hydrogel…”
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Odyssey of a cancer nanoparticle: From injection site to site of action by Nichols, Joseph W., Bae, You Han

“…[Display omitted] ► No drug can be effective against cancer until it is successfully delivered from the administration site to its site of action within the…”
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The tumor EPR effect for cancer drug delivery: Current status, limitations, and alternatives by Sun, Rui, Xiang, Jiajia, Zhou, Quan, Piao, Ying, Tang, Jianbin, Shao, Shiqun, Zhou, Zhuxian, Bae, You Han, Shen, Youqing

“…[Display omitted] Over the past three decades, the enhanced permeability and retention (EPR) effect has been considered the basis of tumor-targeted drug…”
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Recent progress in tumor pH targeting nanotechnology by Lee, Eun Seong, Gao, Zhonggao, Bae, You Han

“…pH-sensitive polymeric micelles and nanogels have recently been developed to target slightly acidic extracellular pH environment of solid tumors. The pH…”
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Lipid raft-mediated and upregulated coordination pathways assist transport of glycocholic acid-modified nanoparticle in a human breast cancer cell line of SK-BR-3 by Deng, Feiyang, Han Bae, You

“…[Display omitted] Bile acid transporter-targeting has been proven to be an effective strategy to improve drug delivery to hepatocytes and enterocytes. With…”
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Long-term oral administration of Exendin-4 to control type 2 diabetes in a rat model by Suzuki, Kenichi, Kim, Kyoung Sub, Bae, You Han

“…Exendin-4 is a glucagon-like peptide-1 (GLP-1) receptor agonist and potent insulinotropic agent for type 2 diabetes patients; however, its therapeutic utility…”
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Self-assembled hydrogel nanoparticles responsive to tumor extracellular pH from pullulan derivative/sulfonamide conjugate: Characterization, aggregation, and adriamycin release in vitro by Na, Kun, Bae, You Han

“…To investigate some physicochemical properties of self-assembled hydrogel nanoparticles of pullulan acetate (PA) and sulfonamide conjugates, as a potential…”
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Stability of bovine serum albumin complexed with PEG-poly( l-histidine) diblock copolymer in PLGA microspheres by Kim, Jong-Ho, Taluja, Ajay, Knutson, Kristine, Han Bae, You

“…The aim of this study was to examine the stability of bovine serum albumin (BSA) in poly( dl-lactic acid- co-glycolic acid) (PLGA) microspheres upon addition…”
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Immune-triggered cancer treatment by intestinal lymphatic delivery of docetaxel-loaded nanoparticle by Kim, Kyoung Sub, Youn, Yu Seok, Bae, You Han

“…The maximally tolerated dose (MTD) approach in conventional chemotherapy accompanies adverse effects, primarily due to high drug concentrations in the blood…”
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Role of a Novel Excipient Poly(ethylene glycol)-b-poly(l-histidine) in Retention of Physical Stability of Insulin at Aqueous/Organic Interface by Taluja, Ajay, Bae, You Han

“…The aim of this study was to investigate whether a cationic polyelectrolyte, poly(ethylene glycol)-b-poly(l-histidine) diblock copolymer (PEG-polyHis), can…”
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Targeted drug delivery to tumors: Myths, reality and possibility by Bae, You Han, Park, Kinam

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Stability issues of polymeric micelles by Bae, You Han, Yin, Haiqing

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Nano-sized drug carriers: Extravasation, intratumoral distribution, and their modeling by Nichols, Joseph W., Sakurai, Yu, Harashima, Hideyoshi, Bae, You Han

“…Navigating intratumoral drug distribution has proven to be one of the most challenging aspects of drug delivery. The barriers are significant and varied;…”
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Tumor heterogeneity and its implication for drug delivery by Denison, Tracy A., Bae, You Han

“…Evidence continues to accumulate that patient tumors contain heterogeneous cell populations, each of which may contribute differently in extent and mechanism…”
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Ovalbumin and Poly(i:c) Encapsulated Dendritic Cell‐Targeted Nanoparticles for Immune Activation in the Small Intestinal Lymphatic System by Kim, Kyoung Sub, Lee, Sanghee, Na, Kun, Bae, You Han

“…Here, antigen and adjuvant encapsulated dendritic cell‐targeted nanoparticles for immune activation in the small intestinal lymphatic system to inhibit…”
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TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors by Sethuraman, Vijay A., Bae, You Han

“…A novel drug targeting system for acidic solid tumors has been developed based on ultra pH-sensitive polymer and cell penetrating TAT. The delivery system…”
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