Search Results - "Badii, Medeea"

GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells by Gaal, Orsolya I., Liu, Ruiqi, Marginean, Dragoș, Badii, Medeea, Cabău, Georgiana, Hotea, Ioana, Nica, Valentin, Colcear, Doina, Pamfil, Cristina, Merriman, Tony R., Rednic, Simona, Popp, Radu A., Crișan, Tania O., Joosten, Leo A. B.

“…Gout is a common autoinflammatory joint diseases characterized by deposition of monosodium urate (MSU) crystals which trigger an innate immune response…”
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Immune Profiling of Patients with Systemic Sclerosis through Targeted Proteomic Analysis by Szabo, Iulia, Badii, Medeea, Gaál, Ildikó O, Szabo, Robert, Sîrbe, Claudia, Humiță, Oana, Joosten, Leo A B, Crișan, Tania O, Rednic, Simona

“…High-throughput proteomic analysis could offer new insights into the pathogenesis of systemic sclerosis (SSc) and reveal non-invasive biomarkers for diagnosis…”
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Enhanced Innate and Acquired Immune Responses in Systemic Sclerosis Primary Peripheral Blood Mononuclear Cells (PBMCs) by Szabo, Iulia, Badii, Medeea, Gaál, Ildikó O., Szabo, Robert, Popp, Radu A., Joosten, Leo A. B., Crişan, Tania O., Rednic, Simona

“…Chronic immune activation in systemic sclerosis is supported by the production of a plethora of cytokines with proven regulatory activities of the immune…”
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Detection of Novel Biomarkers in Pediatric Autoimmune Hepatitis by Proteomic Profiling by Sîrbe, Claudia, Badii, Medeea, Crişan, Tania O, Bența, Gabriel, Grama, Alina, Joosten, Leo A B, Rednic, Simona, Pop, Tudor Lucian

“…Autoimmune hepatitis (AIH) is characterized by immune-mediated hepatocyte injury resulting in the destruction of liver cells, causing inflammation, liver…”
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Hyperuricemia remodels the serum proteome toward a higher inflammatory state by Cabău, Georgiana, Gaal, Orsolya, Badii, Medeea, Nica, Valentin, Mirea, Andreea-Manuela, Hotea, Ioana, Pamfil, Cristina, Popp, Radu A., Netea, Mihai G., Rednic, Simona, Crișan, Tania O., Joosten, Leo A.B.

“…Gout is an autoinflammatory disease triggered by a complex innate immune response to MSU crystals and inflammatory triggers. While hyperuricemia is an…”
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Long-Lasting Enhanced Cytokine Responses Following SARS-CoV-2 BNT162b2 mRNA Vaccination by Cabău, Georgiana, Badii, Medeea, Mirea, Andreea M, Gaal, Orsolya I, van Emst, Liesbeth, Popp, Radu A, Crișan, Tania O, Joosten, Leo A B

“…The mRNA vaccine against COVID-19 protects against severe disease by the induction of robust humoral and cellular responses. Recent studies have shown the…”
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Epigenetic, transcriptional, and functional characterization of myeloid cells in familial Mediterranean fever by Röring, Rutger J., Li, Wenchao, Liu, Ruiqi, Bruno, Mariolina, Zhang, Bowen, Debisarun, Priya A., Gaal, Orsolya, Badii, Medeea, Klück, Viola, Moorlag, Simone J.C.F.M., van de Veerdonk, Frank, Li, Yang, Joosten, Leo A.B., Netea, Mihai G.

“…Familial Mediterranean fever (FMF) is a periodic fever syndrome caused by variation in MEFV. FMF is known for IL-1β dysregulation, but the innate immune…”
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Trained immunity and inflammation in rheumatic diseases by Badii, Medeea, Gaal, Orsolya, Popp, Radu A., Crișan, Tania O., Joosten, Leo A.B.

“…•Innate immune cells can mount an immunological memory called trained immunity.•Long-term innate immune adaptations occur via epigenetic and metabolic…”
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Downregulation of type I interferon signalling pathway by urate in primary human PBMCs by Badii, Medeea, Nica, Valentin, Straton, Ancuța R, Kischkel, Brenda, Gaal, Orsolya, Cabău, Georgiana, Klück, Viola, Hotea, Ioana, Novakovic, Boris, Pamfil, Cristina, Rednic, Simona, Netea, Mihai G, Popp, Radu A, Joosten, Leo A B, Crișan, Tania O

“…Type I interferons (IFN1s) mediate innate responses to microbial stimuli and regulate interleukin (IL)-1 and IL-1 receptor antagonist (Ra) production in human…”
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TGF-[beta] is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells by Klück, Viola, CabÄu, Georgiana, Mies, Linda, Bukkems, Femke, van Emst, Liesbeth, Bakker, René, van Caam, Arjan, Pop, Ioan V, Popp, Radu A, Rednic, Simona, Pamfil, Cristina, FarcaÅ, Marius, Marginean, DragoÅ H, Gaal, Orsolya I, Badii, Medeea O, Hotea, Ioana, Peca, Loredana, Mirea, Andreea-Manuela, Nica, Valentin, Colcear, Doina, Pop, Mariana S, Rus, Ancuta

“…Background Soluble urate leads to a pro-inflammatory phenotype in human monocytes characterized by increased production of IL-1[beta] and downregulation of…”
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TGF-β is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells by Klück, Viola, Cabău, Georgiana, Mies, Linda, Bukkems, Femke, van Emst, Liesbeth, Bakker, René, van Caam, Arjan, Crişan, Tania O, Joosten, Leo A B

“…Soluble urate leads to a pro-inflammatory phenotype in human monocytes characterized by increased production of IL-1β and downregulation of IL-1 receptor…”
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Regulation of SOCS3-STAT3 in urate-induced cytokine production in human myeloid cells by Badii, Medeea, Klück, Viola, Gaal, Orsolya, Cabău, Georgiana, Hotea, Ioana, Nica, Valentin, Mirea, Andreea M., Bojan, Anca, Zdrenghea, Mihnea, Novakovic, Boris, Merriman, Tony R., Liu, Zhaoli, Li, Yang, Xu, Cheng-Jian, Pamfil, Cristina, Rednic, Simona, Popp, Radu A., Crişan, Tania O., Joosten, Leo A.B.

“…•Urate-primed PBMCs of hyperuricemic and gout patients show dysregulated cytokine production.•SOCS3 is enhanced in urate-primed myeloid cells, and this is…”
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Gout-associated SNP at the IL1RN-IL1F10 region is associated with altered cytokine production in PBMCs of patients with gout and controls by Gaal, Orsolya I., Leask, Megan, Nica, Valentin, Cabău, Georgiana, Badii, Medeea, Hotea, Ioana, de Graaf, Dennis M, Zhang, Zhenhua, Li, Yang, Pamfil, Cristina, Rednic, Simona, Merriman, Tony R., Crișan, Tania O., Joosten, Leo A.B.

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Longitudinal study of neuropathy, microangiopathy, and autophagy in sural nerve: Implications for diabetic neuropathy by Mohseni, Simin, Badii, Medeea, Kylhammar, Axel, Thomsen, Niels O. B., Eriksson, Karl‐Fredrik, Malik, Rayaz A., Rosén, Ingmar, Dahlin, Lars B.

“…Objectives The progression and pathophysiology of neuropathy in impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) is poorly understood, especially in…”
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