Specific nutritional supplement (Supportan®) in the supportive care of the radio-chemotherapy treatment of head and neck cancers: biochemical parameters. Preliminary study

This is a preliminary study of a specific nutritional supplement -Supportan(®) - for the clinical support of patients with locally advanced head and neck (H&N) cancers who underwent treatment with concurrent radiochemotherapy (RT-CHT). Seven patients received nutritional supplement (Supportan(®)...

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Bibliographic Details
Published in:	Endocrine, metabolic & immune disorders drug targets Vol. 13; no. 4; p. 348
Main Authors:	Casbarien, Octavio, Cresta, Pablo, Silva, Carolina, Feliu, Maria S, Badia, Alejandra, Delgado, Norberto L, Navigante, Alfredo, Slobodianik, Nora
Format:	Journal Article
Language:	English
Published:	United Arab Emirates 01-12-2013
Subjects:	Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Dietary Proteins - administration & dosage Eicosapentaenoic Acid - administration & dosage Fish Oils - administration & dosage Head and Neck Neoplasms - complications Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - radiotherapy Humans Malnutrition - diet therapy Malnutrition - etiology Nutritional Support - methods Prospective Studies Treatment Outcome
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Summary:	This is a preliminary study of a specific nutritional supplement -Supportan(®) - for the clinical support of patients with locally advanced head and neck (H&N) cancers who underwent treatment with concurrent radiochemotherapy (RT-CHT). Seven patients received nutritional supplement (Supportan(®)) plus habitual diet during a median time of treatment with RT on 7.8 weeks plus concurrent weekly CHT(S). Specific serum protein fractions as a potential useful tool to evaluate the nutritional status were determined. The main objective was to assess the compliance with the above-mentioned treatment. Patients completed the nutritional support, 5 / 7 patients via oral route and 2/7 patients through nasogastric tube. All studied patients, that completed treatment, had not severe mucositis -ulcera, hemrraghe and/ or infection. None of them had another severe toxicity by treatment nor had impairment of Pefomance Status. No differences in all specific sera proteins were observed between S and To. In this preliminary study of few patients, we have observed a potential usefulness of Supportan(®) in the compliance of concurrent RT-CHT in patients with H&N cancers; moreover, its administration was useful to maintain the initial biochemical nutritional profile.
ISSN:	2212-3873
DOI:	10.2174/1871530313666131122151325