Construction of 3-amino-9-ethylcarbazole scaffold for multifunctional applications: Chemosensor for copper(II) ions along with antibacterial, antioxidant and anti-inflammatory activity

[Display omitted] •A very simple and novel synthetic route for the probe is designed and executed.•The titled probe has shown good selectivity towards Cu2+ ions in physiological environment.•The response time was very quick to sense Cu2 + ions in the presence of other competitive cations.•The probe...

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Bibliographic Details
Published in:	Results in Chemistry Vol. 6; p. 101141
Main Authors:	Sathiyaraj, G., Vignesh, A., Priyanka, K., Neethu, K.S., Badhmapriya, D., Preethi, K., Dharmaraj, N., Kaveri, M.V.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-12-2023 Elsevier
Subjects:	Carbazole based metal sensor Inflammation healing Microbes inhibition Naked eye detection of copper ions Oxidative stress reduction Photo electron transfer Oxidative stress reduction Carbazole based metal sensor Inflammation healing Naked eye detection of copper ions Photo electron transfer Microbes inhibition
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Summary:	[Display omitted] •A very simple and novel synthetic route for the probe is designed and executed.•The titled probe has shown good selectivity towards Cu2+ ions in physiological environment.•The response time was very quick to sense Cu2 + ions in the presence of other competitive cations.•The probe molecule also displayed considerable antibacterial potential. This work describes the fabrication of a carbazole derivative 1 namely (E)-5-(diethylamino)-2-((9-ethyl-9H-carbazol-3-yl)imino)methyl)phenol(1) based colorimetric probe for the selective detection of copper (II) ions. The as-prepared carbazole derivative was characterized using various spectral techniques including UV–visible absorption, Emission, FT-IR, 1H NMR, 13C NMR and mass spectra. The colorimetric chemosensing potential of the synthesized carbazole derivative 1 to detect Cu2+ ions in a solution of different cations at different emission wavelengths based on photo-induced electron transfer (PET) mechanism was undertaken. In addition, the probe 1 showed significant DPPH scavenging activity. Antimicrobial and anti-inflammatory activities of the carbazole derivative 1 were also assessed. The selectivity of probe 1 towards Cu2+ ions could be exploited to reduce copper induced toxicity.
ISSN:	2211-7156 2211-7156
DOI:	10.1016/j.rechem.2023.101141