Search Results - "Bader, Jakob"

MS-Based Proteomics of Body Fluids: The End of the Beginning by Bader, Jakob M., Albrecht, Vincent, Mann, Matthias

“…Accurate biomarkers are a crucial and necessary precondition for precision medicine, yet existing ones are often unspecific and new ones have been very slow to…”
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Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome by Fitzner, Dirk, Bader, Jakob M., Penkert, Horst, Bergner, Caroline G., Su, Minhui, Weil, Marie-Theres, Surma, Michal A., Mann, Matthias, Klose, Christian, Simons, Mikael

“…Gene and protein expression data provide useful resources for understanding brain function, but little is known about the lipid composition of the brain. Here,…”
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The proteome landscape of the kingdoms of life by Müller, Johannes B., Geyer, Philipp E., Colaço, Ana R., Treit, Peter V., Strauss, Maximilian T., Oroshi, Mario, Doll, Sophia, Virreira Winter, Sebastian, Bader, Jakob M., Köhler, Niklas, Theis, Fabian, Santos, Alberto, Mann, Matthias

“…Proteins carry out the vast majority of functions in all biological domains, but for technological reasons their large-scale investigation has lagged behind…”
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Plasma Proteome Profiling to detect and avoid sample‐related biases in biomarker studies by Geyer, Philipp E, Voytik, Eugenia, Treit, Peter V, Doll, Sophia, Kleinhempel, Alisa, Niu, Lili, Müller, Johannes B, Buchholtz, Marie‐Luise, Bader, Jakob M, Teupser, Daniel, Holdt, Lesca M, Mann, Matthias

“…Plasma and serum are rich sources of information regarding an individual's health state, and protein tests inform medical decision making. Despite major…”
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Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease by Bader, Jakob M, Geyer, Philipp E, Müller, Johannes B, Strauss, Maximilian T, Koch, Manja, Leypoldt, Frank, Koertvelyessy, Peter, Bittner, Daniel, Schipke, Carola G, Incesoy, Enise I, Peters, Oliver, Deigendesch, Nikolaus, Simons, Mikael, Jensen, Majken K, Zetterberg, Henrik, Mann, Matthias

“…Neurodegenerative diseases are a growing burden, and there is an urgent need for better biomarkers for diagnosis, prognosis, and treatment efficacy. Structural…”
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Interaction of 7SK with the Smn complex modulates snRNP production by Ji, Changhe, Bader, Jakob, Ramanathan, Pradhipa, Hennlein, Luisa, Meissner, Felix, Jablonka, Sibylle, Mann, Matthias, Fischer, Utz, Sendtner, Michael, Briese, Michael

“…Gene expression requires tight coordination of the molecular machineries that mediate transcription and splicing. While the interplay between transcription…”
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Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr by Salehi, Saeede, Zare, Abdolhossein, Prezza, Gianluca, Bader, Jakob, Schneider, Cornelius, Fischer, Utz, Meissner, Felix, Mann, Matthias, Briese, Michael, Sendtner, Michael

“…The neuronal RNA-binding protein Ptbp2 regulates neuronal differentiation by modulating alternative splicing programs in the nucleus. Such programs contribute…”
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hnRNP R promotes O-GlcNAcylation of eIF4G and facilitates axonal protein synthesis by Zare, Abdolhossein, Salehi, Saeede, Bader, Jakob, Schneider, Cornelius, Fischer, Utz, Veh, Alexander, Arampatzi, Panagiota, Mann, Matthias, Briese, Michael, Sendtner, Michael

“…Motoneurons critically depend on precise spatial and temporal control of translation for axon growth and the establishment and maintenance of neuromuscular…”
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Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons by Riemenschneider, Henrick, Guo, Qiang, Bader, Jakob, Frottin, Frédéric, Farny, Daniel, Kleinberger, Gernot, Haass, Christian, Mann, Matthias, Hartl, F. Ulrich, Baumeister, Wolfgang, Hipp, Mark S, Meissner, Felix, Fernández‐Busnadiego, Rubén, Edbauer, Dieter

“…Aggregation of the multifunctional RNA‐binding protein TDP‐43 defines large subgroups of amyotrophic lateral sclerosis and frontotemporal dementia and…”
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Phosphoinositide kinase signaling controls ER-PM cross-talk by Omnus, Deike J, Manford, Andrew G, Bader, Jakob M, Emr, Scott D, Stefan, Christopher J

“…Membrane lipid dynamics must be precisely regulated for normal cellular function, and disruptions in lipid homeostasis are linked to the progression of several…”
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Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity by Hartmann, Hannelore, Hornburg, Daniel, Czuppa, Mareike, Bader, Jakob, Michaelsen, Meike, Farny, Daniel, Arzberger, Thomas, Mann, Matthias, Meissner, Felix, Edbauer, Dieter

“…Frontotemporal dementia and amyotrophic lateral sclerosis patients with mutation show cytoplasmic poly-GR and poly-PR aggregates. Short poly-(Gly-Arg) and…”
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A heat-sensitive Osh protein controls PI4P polarity by Omnus, Deike J, Cadou, Angela, Thomas, Ffion B, Bader, Jakob M, Soh, Nathaniel, Chung, Gary H C, Vaughan, Andrew N, Stefan, Christopher J

“…Phosphoinositide lipids provide spatial landmarks during polarized cell growth and migration. Yet how phosphoinositide gradients are oriented in response to…”
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Tricalbin proteins regulate plasma membrane phospholipid homeostasis by Thomas, Ffion B, Omnus, Deike J, Bader, Jakob M, Chung, Gary Hc, Kono, Nozomu, Stefan, Christopher J

“…The evolutionarily conserved extended synaptotagmin (E-Syt) proteins are calcium-activated lipid transfer proteins that function at contacts between the ER and…”
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Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin by Ghanawi, Hanaa, Hennlein, Luisa, Zare, Abdolhossein, Bader, Jakob, Salehi, Saeede, Hornburg, Daniel, Ji, Changhe, Sivadasan, Rajeeve, Drepper, Carsten, Meissner, Felix, Mann, Matthias, Jablonka, Sibylle, Briese, Michael, Sendtner, Michael

“…Abstract Neurons critically rely on the functions of RNA-binding proteins to maintain their polarity and resistance to neurotoxic stress. HnRNP R has a diverse…”
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Cortical circuit alterations precede motor impairments in Huntington’s disease mice by Burgold, Johanna, Schulz-Trieglaff, Elena Katharina, Voelkl, Kerstin, Gutiérrez-Ángel, Sara, Bader, Jakob Maximilian, Hosp, Fabian, Mann, Matthias, Arzberger, Thomas, Klein, Rüdiger, Liebscher, Sabine, Dudanova, Irina

“…Huntington’s disease (HD) is a devastating hereditary movement disorder, characterized by degeneration of neurons in the striatum and cortex. Studies in human…”
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Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons by Riemenschneider, Henrick, Guo, Qiang, Bader, Jakob, Frottin, Frédéric, Farny, Daniel, Kleinberger, Gernot, Haass, Christian, Mann, Matthias, Hartl, F Ulrich, Baumeister, Wolfgang, Hipp, Mark S, Meissner, Felix, Fernández-Busnadiego, Rubén, Edbauer, Dieter

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Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status by Bader, Jakob Maximilian, Deigendesch, Nikolaus, Misch, Martin, Mann, Matthias, Koch, Arend, Meissner, Felix

“…High-grade adult-type diffuse gliomas are malignant neuroepithelial tumors with poor survival rates in combined chemoradiotherapy. The current WHO…”
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Forced flow He vapor cooled critical current testing facility for measurements of superconductors in a wide temperature and magnetic field range by Baskys, Algirdas, Hopkins, Simon C., Bader, Jakob, Glowacki, Bartek A.

“…•A design and construction of a low cost critical current testing facility presented.•Stable sample temperatures down to 10K were achieved.•System was…”
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