Search Results - "Badenhorst, Philip"

Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus) by Feys, Hendrik B., Roodt, Jan, Vandeputte, Nele, Pareyn, Inge, Lamprecht, Seb, van Rensburg, Walter J., Anderson, Patricia J., Budde, Ulrich, Louw, Vernon J., Badenhorst, Philip N., Deckmyn, Hans, Vanhoorelbeke, Karen

“…Thrombotic thrombocytopenic purpura (TTP) is the prototypical microangiopathy characterized by disseminated microthromboses, hemolytic anemia, and ultimately…”
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The Cape Chacma baboon is not suitable for evaluating human targeted anti-GPVI agents by Janse van Rensburg, Walter J., Badenhorst, Philip N., Roodt, Jan P.

“…An effective and safe anti-platelet drug is central to the management of patients with acute coronary syndrome (ACS). Glycoprotein VI (GPVI) is currently…”
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Performance and utility of a cost-effective collagen-binding assay for the laboratory diagnosis of Von Willebrand disease by Meiring, Muriel, Badenhorst, Philip N, Kelderman, Mareli

“…The collagen-binding assay, a functional assay of Von Willebrand factor (VWF), discriminates the subtypes of Von Willebrand disease (VWD). Commercial collagen…”
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Coronary artery in-stent stenosis persists despite inhibition of the von Willebrand factor--collagen interaction in baboons by De Meyer, Simon F, Staelens, Stephanie, Badenhorst, Philip N, Pieters, Henry, Lamprecht, Seb, Roodt, Jan, Janssens, Stefan, Meiring, Muriel, Vanhoorelbeke, Karen, Bruwer, André, Brown, Stephen, Deckmyn, Hans

“…Revascularization techniques, such as angioplasty and stent implantation, frequently lead to restenosis due to the formation of neointima after platelet…”
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Tirofiban versus abciximab: tirofiban is administered at suboptimal dosages when evaluated in an arterial thrombosis model in non-human primates by van Rensburg, Walter J. Janse, Roodt, Jan P., Lamprecht, Seb, Meiring, S. Muriel, Badenhorst, Philip N.

“…To prevent thrombosis in high-risk acute coronary syndrome patients undergoing percutaneous coronary intervention for re-vascularisation, concomitant…”
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Thrombophilia Screening in Pregnancy by Jordaan, Dorothy-Jo, Schoon, Martinus Gerhardus, Nel Badenhorst, Philip

“…Thromboembolism in pregnancy is a major contributor to pregnancy morbidity and mortality with potentially serious adverse effects for both mother and fetus…”
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In vitro effect of a thrombin inhibition peptide selected by phage display technology by Meiring, Muriel S, Litthauer, Derek, Hársfalvi, Jolan, van Wyk, Veronica, Badenhorst, Philip N, Kotzé, Harry F

“…A repeated selection of phages from a cyclic heptapeptide phage display library resulted in the enrichment of phages that bind to human α-thrombin. One clone…”
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The effect of monoclonal anti-human-platelet antibodies on platelet kinetics in a baboon model: IgG subclass dependency by Coetzee, L M, Pieters, H, van Wyk, V, Cooper, S, Roodt, J, De Reys, S, Badenhorst, P N

“…We assessed the in vivo effect of six intact anti-human antiplatelet antibodies of two major IgG subclasses on platelet kinetics in baboons. Five of the six…”
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Laboratory diagnosis and management of von Willebrand disease in South Africa by Meiring, Muriel, Coetzee, Marius, Kelderman, Mareli, Badenhorst, Philip

“…Patients with Von Willebrand disease (VWD) in South Africa are cared for in 17 Hemophilia Treatment Centers. The exact prevalence of the disease is uncertain,…”
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Thrombotic thrombocytopenic purpura directly linked with ADAMTS 13 inhibition in the baboon (Papio ursinus) by FEYS, Hendrik B, ROODT, Jan, DECKMYN, Hans, VANHOORELBEKE, Karen, VANDEPUTTE, Nele, PAREYN, Inge, LAMPRECHT, Seb, VAN RENSBURG, Walter J, ANDERSON, Patricia J, BUDDE, Ulrich, LOUW, Vernon J, BADENHORST, Philip N

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The Determination of the Inhibitory Activity of Some Factor VIII Type II Inhibitor Antibodies Is Biased by the Type of Factor VIII Assay by Jacquemin, Marc G., Lamprecht, Seb, Lavend'homme, Renaud, Roodt, Jan, Chatelain, Bernard, Deneys, Veronique, Dewaele, Jeroen, Stassen, Jean-Marie, Meiring, Muriel, Saint-Remy, Jean Marie, Pieters, Henry, Badenhorst, Philip

“…Although type II Factor VIII (FVIII) inhibitor antibodies inhibit only partially FVIII activity, even when such antibodies are in very large excess over FVIII,…”
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An Animal Model Suitable for Predicting In Vivo Behavior of Platelets in Humans: A Tool for New Product Development by Blajchman, Morris A., Li, Junzhi, Kulczycky, Myron, Woskowska, Zofia, Pieters, Henry, Roodt, Jan, Badenhorst, Philip, Crookes, Robert, Heyns, Anthon, Goodrich, Raymond

“…Testing platelet in vivo activity in an animal model remains an attractive approach for the pre-clinical evaluation of platelets that have been treated or…”
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A comparison between the use of recombinant hirudin and heparin during hemodialysis by van Wyk, Veronica, Badenhorst, Philip N., Luus, Herman G., Kotzé, Harry F.

“…A comparison between the use of recombinant hirudin and heparin during hemodialysis. The purpose of this study was to determine the anticoagulant and…”
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Kinetics and fate of indium 111 oxine-labeled platelets in patients with aortic aneurysms by Heyns, A D, Lötter, M G, Badenhorst, P N, Pieters, H, Nel, C J, Minnaar, P C

“…The survival and sites of sequestration of indium 111 oxine-labeled autologous platelets were studied quantitatively in six patients with aortic aneurysms. The…”
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Creating a Digital Twin for a Hydroponic Green Fodder System to Evaluate an Improved Airflow Configuration by Luwes, Nicolaas, Brits, Hendrik Christiaan, Badenhorst, Kyle Philip, Bester, Evane Dior

“…Smart Cities is a research domain that focuses on achieving sustainable development amidst population growth. One key facet within the realm of smart city…”
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Haematology outreach clinics in the Free State and Northern Cape by COETZEE, M. J, BADENHORST, P. N, LE LOUX, E. P, DOMAN, M. J

“…Evaluation of haematology outreach clinics in the Northern Cape and Free State. Retrospective analysis of records from March 1994 to February 1996. Central…”
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Haemostatic profile of the San (Bushmen) relocated to Schmidtsdrif by VAN WYK, V, COETZEE, M. J, ALEXANDER, K. C, BADENHORST, P. N

“…To document the routine haemostatic variables of a group of San relocated from Namibia to South Africa. Cross-sectional study done in two stages. Schmidtsdrif…”
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Comparison of Oxine and Tropolone Methods for Labeling Human Platelets with Indium-111 by Kotze, Harry F, Heyns, Anthon du P, Lotter, Mattheus G, Pieters, Henry, Roodt, Johannes P, Sweetlove, M. Ann, Badenhorst, Philip N

“…The effect of the chelates oxine and tropolone, used to label platelets, on the kinetics of indium-111-(111In) labeled platelets was studied in twelve normal…”
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Plasma volume expansion with Haemaccel does not impair haemostasis during reduction mammaplasty by van Wyk, V, Marais, A, Diedericks, J, van der Walt, E, Dumas, L, Badenhorst, P N, Alexander, K C, Kotzé, H F

“…An in vivo study under well-controlled conditions was undertaken to determine the effect of Haemaccel, a colloidal plasma volume expander, on normal…”
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Evaluation of Mathematic Models to Assess Platelet Kinetics by Lotter, Mattheus G, Heyns, Anthon du P, Badenhorst, Philip N, Wessels, Paula, van Zyl, J. Martin, Kotze, Harry F, Minnaar, Philip C

“…Twelve mathematic methods used to calculate the mean platelet survival time were compared by determining the "goodness of fit" of the models to the platelet…”
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