Search Results - "Badellino, Karen O."

Vitamin D and the Bariatric Surgical Patient: A Review by Compher, Charlene W., Badellino, Karen O., Boullata, Joseph I.

“…Objective Adiposity has been inversely associated with vitamin D concentration across a range of body mass index values and cultural groups. As obesity has…”
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Endothelial Lipase Is Increased In Vivo by Inflammation in Humans by BADELLINO, Karen O, WOLFE, Megan L, REILLY, Muredach P, RADER, Daniel J

“…Endothelial lipase (EL) is a plasma lipase that we previously reported to be significantly correlated with all features of the metabolic syndrome in humans,…”
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Obesity and Inflammation: Lessons From Bariatric Surgery by Compher, Charlene, Badellino, Karen O.

“…Background: Obesity is associated with a series of comorbid conditions that are characterized by an inflammatory state. The purpose of this review is to update…”
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Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol by Khetarpal, Sumeet A, Edmondson, Andrew C, Raghavan, Avanthi, Neeli, Hemanth, Jin, Weijun, Badellino, Karen O, Demissie, Serkalem, Manning, Alisa K, DerOhannessian, Stephanie L, Wolfe, Megan L, Cupples, L Adrienne, Li, Mingyao, Kathiresan, Sekar, Rader, Daniel J

“…Genome-wide association studies (GWAS) have successfully identified loci associated with quantitative traits, such as blood lipids. Deep resequencing studies…”
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Identification of the Active Form of Endothelial Lipase, a Homodimer in a Head-to-Tail Conformation by Griffon, Nathalie, Jin, Weijin, Petty, Thomas J., Millar, John, Badellino, Karen O., Saven, Jeffery G., Marchadier, Dawn H., Kempner, Ellis S., Billheimer, Jeffrey, Glick, Jane M., Rader, Daniel J.

“…Endothelial lipase (EL) is a member of a subfamily of lipases that act on triglycerides and phospholipids in plasma lipoproteins, which also includes…”
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Endothelial lipase is associated with inflammation in humans by Paradis, Marie-Eve, Badellino, Karen O., Rader, Daniel J., Deshaies, Yves, Couture, Patrick, Archer, Wiedad R., Bergeron, Nathalie, Lamarche, Benoît

“…The aim of this study was to investigate the extent to which inflammation is linked with plasma endothelial lipase (EL) concentrations among healthy sedentary…”
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A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis[S] by Brown, Robert J., Edmondson, Andrew C., Griffon, Nathalie, Hill, Theophelus B., Fuki, Ilia V., Badellino, Karen O., Li, Mingyao, Wolfe, Megan L., Reilly, Muredach P., Rader, Daniel J.

“…Human endothelial lipase (EL) is a member of a family of lipases and phospholipases that are involved in the metabolism of plasma lipoproteins. EL displays a…”
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Visceral Adiposity and Endothelial Lipase by Paradis, Marie-Eve, Badellino, Karen O., Rader, Daniel J., Tchernof, André, Richard, Christian, Luu-The, Van, Deshaies, Yves, Bergeron, Jean, Archer, Wiedad R., Couture, Patrick, Bergeron, Nathalie, Lamarche, Benoı̂t

“…Context: Overexpression of endothelial lipase (EL) has been shown to reduce plasma high-density lipoprotein cholesterol levels in animal models. However, the…”
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Role of N-linked glycosylation in the secretion and activity of endothelial lipase by Miller, Gwen C., Long, Christopher J., Bojilova, Ekaterina D., Marchadier, Dawn, Badellino, Karen O., Blanchard, Nadine, Fuki, Ilia V., Glick, Jane M., Rader, Daniel J.

“…Human endothelial lipase (EL), a member of the triglyceride lipase gene family, has five potential N-linked glycosylation sites, two of which are conserved in…”
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Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis by Badellino, Karen O, Wolfe, Megan L, Reilly, Muredach P, Rader, Daniel J

“…Endothelial lipase (EL), a new member of the lipase family, has been shown to modulate high-density lipoprotein (HDL-C) metabolism and atherosclerosis in mouse…”
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Factor XI Binding to the Platelet Glycoprotein Ib-IX-V Complex Promotes Factor XI Activation by Thrombin by Baglia, Frank A., Badellino, Karen O., Li, Chester Q., López, José A., Walsh, Peter N.

“…Factor XI binds to high affinity sites on the surface of stimulated platelets where it is efficiently activated by thrombin. Here, we provide evidence that the…”
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The role of endothelial lipase in high-density lipoprotein metabolism by Badellino, Karen O, Rader, Daniel J

“…PURPOSE OF REVIEWElevating high-density lipoprotein levels is increasingly being identified as an essential strategy for the prevention of atherosclerosis…”
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High-Dose Statin Therapy for Secondary Prevention of Stroke: Stroke Prevention by Aggressive Reduction in Cholesterol Levels Study Review by Schwertz, Dorie W, Badellino, Karen O

“…It has been shown that HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors (statins) lower the incidence of a first stroke in patients with…”
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Allosteric Modification of Factor XIa Functional Activity upon Binding to Polyanions by Sinha, Dipali, Badellino, Karen O, Marcinkiewicz, Mariola, Walsh, Peter N

“…The effects of several polyanions on the hydrolysis of the chromogenic substrate l-pyroglutamyl-l-prolyl-l-arginyl-p-nitroaniline (S-2366) and on the…”
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Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin by Baglia, Frank A, Badellino, Karen O, Li, Chester Q, López, José A, Walsh, Peter N

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Localization of a Heparin Binding Site in the Catalytic Domain of Factor XIa by Badellino, Karen O, Walsh, Peter N

“…Inhibition of factor XIa by protease nexin II (K i ≈ 450 pM) is potentiated by heparin (K I ≈ 30 pM). The inhibition of the isolated catalytic domain of factor…”
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Effect of Fenofibrate on Plasma Lipoprotein Composition and Kinetics in Patients With Complete Hepatic Lipase Deficiency by Ruel, Isabelle L, Lamarche, Benoît, Mauger, Jean-François, Badellino, Karen O, Cohn, Jeffrey S, Marcil, Michel, Couture, Patrick

“…OBJECTIVE—The goal of this study was to characterize the effect of microcoated fenofibrate (160 mg/day for 6 months) on plasma lipoprotein composition and…”
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A Binding Site for the Kringle II Domain of Prothrombin in the Apple 1 Domain of Factor XI by Baglia, Frank A., Badellino, Karen O., Ho, David H., Dasari, V. Rao, Walsh, Peter N.

“…Previously we defined binding sites for high molecular weight kininogen (HK) and thrombin in the Apple 1 (A1) domain of factor XI (FXI). Since prothrombin (and…”
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Protease Nexin II Interactions with Coagulation Factor XIa Are Contained within the Kunitz Protease Inhibitor Domain of Protease Nexin II and the Factor XIa Catalytic Domain by Badellino, Karen O, Walsh, Peter N

“…Protease nexin II, a platelet-secreted protein containing a Kunitz-type domain, is a potent inhibitor of factor XIa with an inhibition constant of 250−400 pM…”
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Mining the LIPG Allelic Spectrum Reveals the Contribution of Rare and Common Regulatory Variants to HDL Cholesterol: e1002393 by Khetarpal, Sumeet A, Edmondson, Andrew C, Raghavan, Avanthi, Neeli, Hemanth, Jin, Weijun, Badellino, Karen O, Demissie, Serkalem, Manning, Alisa K, DerOhannessian, Stephanie L, Wolfe, Megan L, Cupples, L Adrienne, Li, Mingyao, Kathiresan, Sekar, Rader, Daniel J

“…Genome-wide association studies (GWAS) have successfully identified loci associated with quantitative traits, such as blood lipids. Deep resequencing studies…”
Get full text