Search Results - "Badell, I. Raul"

Costimulatory Blockade and Solid Organ Transplantation: The Past, Present, and Future by Kitchens, William H., Larsen, Christian P., Badell, I. Raul

“…Belatacept is the first costimulatory blockade agent clinically approved for transplant immunosuppression. Although more than 10 years of study have…”
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2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses by Liu, Danya, Krummey, Scott M, Badell, I Raul, Wagener, Maylene, Schneeweis, Lumelle A, Stetsko, Dawn K, Suchard, Suzanne J, Nadler, Steven G, Ford, Mandy L

“…Mounting evidence in models of both autoimmunity and chronic viral infection suggests that the outcome of T cell activation is critically impacted by the…”
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T follicular helper cells in the generation of alloantibody and graft rejection by Badell, I. Raul, Ford, Mandy L.

“…T follicular helper (Tfh) cells are an increasingly relevant CD4 T cell subset responsible for the provision of help to B cells for the generation of an…”
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Three-year Outcomes After Conversion From Monthly to Every 2-month Belatacept Maintenance Therapy in Kidney Transplant Recipients: Results From a Randomized Controlled Trial by Johnson, Aileen C., Karadkhele, Geeta M., Shenvi, Neeta, Easley, Kirk A., Larsen, Christian P., Badell, I. Raul

“…Maintenance immunosuppression with belatacept following kidney transplantation results in improved long-term graft function as compared with calcineurin…”
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CXCL13 Is an Indicator of Germinal Center Activity and Alloantibody Formation Following Transplantation by Crichton, Emma S., Zeng, Shan, La Muraglia, G. Michael, Badell, I. Raul

“…Donor-specific antibodies (DSA) are a recognized cause of allograft injury, yet biomarkers that indicate their development posttransplant or guide management…”
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Memory T follicular helper cells drive donor-specific antibodies independent of memory B cells and primary germinal center and alloantibody formation by Zeng, Shan, Crichton, Emma S., Ford, Mandy L., Badell, I. Raul

“…Human leukocyte antigen antibodies are important immunologic mediators of renal allograft loss and are difficult to control. The inability to permanently…”
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Indeterminate group A subtyping for prospective renal transplant donor by Achram, Robert, Zerra, Patricia E., Delvadia, Bhaveshkumar, Thompson, Louisa, Badell, I. Raul, Roback, John D., Sullivan, H. Cliff

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Microencapsulated adult porcine islets transplanted intraperitoneally in streptozotocin‐diabetic non‐human primates by Safley, Susan A., Kenyon, Norma S., Berman, Dora M., Barber, Graham F., Willman, Melissa, Duncanson, Stephanie, Iwakoshi, Neal, Holdcraft, Robert, Gazda, Lawrence, Thompson, Peter, Badell, I. Raul, Sambanis, Athanassios, Ricordi, Camillo, Weber, Collin J.

“…Background Xenogeneic donors would provide an unlimited source of islets for the treatment of type 1 diabetes (T1D). The goal of this study was to assess the…”
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Implementation of an Online Intraoperative Assessment of Technical Performance for Surgical Trainees by Faber, David A., Hinman, Johanna M., Knauer, Eric M., Hechenbleikner, Elizabeth M., Badell, I. Raul, Lin, Edward, Srinivasan, Jahnavi K., Chahine, A. Alfred, Papandria, Dominic J.

“…Assessment of surgical resident technical performance is an integral component of any surgical training program. Timely assessment delivered in a structured…”
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Belatacept in Kidney Transplant Recipients With Failed Allografts for the Prevention of Humoral Sensitization: A Pilot Randomized Controlled Trial by Badell, I. Raul, Bray, Robert A., Elbein, Rivka, Chami, Ashtar S., Easley, Kirk A., Pastan, Stephen O., Guasch, Antonio, Gebel, Howard M., Adams, Andrew B., Larsen, Christian P.

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Selective CD28 blockade attenuates CTLA-4-dependent CD8+ memory T cell effector function and prolongs graft survival by Liu, Danya, Badell, I Raul, Ford, Mandy L

“…Memory T cells pose a significant problem to successful therapeutic control of unwanted immune responses during autoimmunity and transplantation, as they are…”
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Belatacept and CD28 Costimulation Blockade: Preventing and Reducing Alloantibodies over the Long Term by Parsons, Ronald F., Larsen, Christian P., Pearson, Thomas C., Badell, I. Raul

“…Purpose of Review Highlight developments in T and B cell biology that are helping elucidate the mechanisms underlying CD28 pathway blockade-mediated inhibition…”
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TNFα and pathologic bone resorption by Boyce, Brendan E, Li, Ping, Yao, Zhenqiang, Zhang, Qian, Badell, I. Raul, Schwarz, Edward M., O’Keefe, Regis J., Xing, Lianping

“…Chronic inflammatory bone diseases, such as rheumatoid arthritis, periodontal disease and aseptic periprosthetic osteolysis, are characterized by bone loss…”
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NF-κB p50 and p52 Regulate Receptor Activator of NF-κB Ligand (RANKL) and Tumor Necrosis Factor-induced Osteoclast Precursor Differentiation by Activating c-Fos and NFATc1 by Yamashita, Teruhito, Yao, Zhenqiang, Li, Fang, Zhang, Qian, Badell, I. Raul, Schwarz, Edward M., Takeshita, Sunao, Wagner, Erwin F., Noda, Masaki, Matsuo, Koichi, Xing, Lianping, Boyce, Brendan F.

“…Postmenopausal osteoporosis and rheumatoid joint destruction result from increased osteoclast formation and bone resorption induced by receptor activator of…”
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Circulating T follicular helper cells are a biomarker of humoral alloreactivity and predict donor‐specific antibody formation after transplantation by La Muraglia, Glenn Michael, Wagener, Maylene E., Ford, Mandy L., Badell, Idelberto Raul

“…Donor‐specific antibodies (DSAs) contribute to renal allograft loss. However, biomarkers to guide clinical management of DSA posttransplant or detect humoral…”
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Every two-month belatacept maintenance therapy in kidney transplant recipients greater than one-year post-transplant: a randomized, non-inferiority trial by Badell, I. Raul, Parsons, Ronald F., Karadkhele, Geeta, Cristea, Octav, Mead, Sue, Thomas, Shine, Robertson, Jennifer M., Kim, Grace S., Hanfelt, John J., Pastan, Stephen O., Larsen, Christian P.

“…Belatacept results in improved kidney transplant outcomes, but utilization has been limited by logistical barriers related to monthly (q1m) intravenous…”
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Superior inhibition of alloantibody responses with selective CD28 blockade is CTLA‐4 dependent and T follicular helper cell specific by La Muraglia, Glenn Michael, Zeng, Susan, Crichton, Emma S., Wagener, Maylene E., Ford, Mandy L., Badell, Idelberto Raul

“…Anti‐donor antibodies cause immunologic injury in transplantation. CD28 blockade with CTLA‐4‐Ig has the ability to reduce the incidence of these donor‐specific…”
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The impact of belatacept on third‐party HLA alloantibodies in highly sensitized kidney transplant recipients by Parsons, Ronald F., Zahid, Arslan, Bumb, Shalini, Decker, Hannah, Sullivan, Harold C., Eun‐Hyung Lee, Frances, Badell, Idelberto Raul, Ford, Mandy L., Larsen, Christian P., Pearson, Thomas C., Jackson, Annette M., Chen, Dong‐Feng, Levine, Matthew, Kamoun, Malek, Bray, Robert A., Gebel, Howard M.

“…Recent evidence suggests that belatacept reduces the durability of preexisting antibodies to class I and class II human leukocyte antigens (HLAs). In this case…”
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TNF.ALPHA. and pathologic bone resorption by Boyce, Brendan E, Li, Ping, Yao, Zhenqiang, Zhang, Qian, Badell, I. Raul, Schwarz, Edward M., O’Keefe, Regis J., Xing, Lianping

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Cover Image, Volume 25, Issue 6 by Safley, Susan A., Kenyon, Norma S., Berman, Dora M., Barber, Graham F., Willman, Melissa, Duncanson, Stephanie, Iwakoshi, Neal, Holdcraft, Robert, Gazda, Lawrence, Thompson, Peter, Badell, I. Raul, Sambanis, Athanassios, Ricordi, Camillo, Weber, Collin J.

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