Search Results - "Badea, Tudor C."

A system to measure the Optokinetic and Optomotor response in mice by Kretschmer, Friedrich, Sajgo, Szilard, Kretschmer, Viola, Badea, Tudor C.

“…•A novel system for automated detection of Optomotor and Optokinetic responses under identical stimulation conditions reveals parallels between the two…”
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Distinct Roles of Transcription Factors Brn3a and Brn3b in Controlling the Development, Morphology, and Function of Retinal Ganglion Cells by Badea, Tudor C., Cahill, Hugh, Ecker, Jen, Hattar, Samer, Nathans, Jeremy

“…Transcriptional regulatory networks that control the morphologic and functional diversity of mammalian neurons are still largely undefined. Here we dissect the…”
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Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina by Wang, Xu, Zhao, Lian, Zhang, Jun, Fariss, Robert N, Ma, Wenxin, Kretschmer, Friedrich, Wang, Minhua, Qian, Hao Hua, Badea, Tudor C, Diamond, Jeffrey S, Gan, Wen-Biao, Roger, Jerome E, Wong, Wai T

“…Microglia, the principal resident immune cell of the CNS, exert significant influence on neurons during development and in pathological situations. However, if…”
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Class 5 Transmembrane Semaphorins Control Selective Mammalian Retinal Lamination and Function by Matsuoka, Ryota L., Chivatakarn, Onanong, Badea, Tudor C., Samuels, Ivy S., Cahill, Hugh, Katayama, Kei-ichi, Kumar, Sumit R., Suto, Fumikazu, Chédotal, Alain, Peachey, Neal S., Nathans, Jeremy, Yoshida, Yutaka, Giger, Roman J., Kolodkin, Alex L.

“…In the vertebrate retina, neurites from distinct neuronal cell types are constrained within the plexiform layers, allowing for establishment of retinal…”
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Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization by Ye, Xin, Wang, Yanshu, Cahill, Hugh, Yu, Minzhong, Badea, Tudor C., Smallwood, Philip M., Peachey, Neal S., Nathans, Jeremy

“…Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5…”
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Molecular studies into cell biological role of Copine-4 in Retinal Ganglion Cells by Goel, Manvi, Aponte, Angel M, Wistow, Graeme, Badea, Tudor C

“…The molecular mechanisms underlying morphological diversity in retinal cell types are poorly understood. We have previously reported that several members of…”
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Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration by Wang, Xu, Zhao, Lian, Zhang, Yikui, Ma, Wenxin, Gonzalez, Shaimar R, Fan, Jianguo, Kretschmer, Friedrich, Badea, Tudor C, Qian, Hao-Hua, Wong, Wai T

“…Photoreceptor degeneration is a cause of irreversible vision loss in incurable blinding retinal diseases including retinitis pigmentosa (RP) and atrophic…”
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Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision by Altimus, Cara M, Zhao, Haiqing, Badea, Tudor C, Yau, King-Wai, Ecker, Jennifer L, Barnard, Alun R, Lall, Gurprit S, Hankins, Mark W, Berson, David M, Haq, Shafiqul, Lucas, Robert J, Güler, Ali D, Hattar, Samer, Liao, Hsi-Wen, Cahill, Hugh

“…Rod and cone photoreceptors detect light and relay this information through a multisynaptic pathway to the brain by means of retinal ganglion cells (RGCs)…”
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Role of RGC-32 in multiple sclerosis and neuroinflammation – few answers and many questions by Tatomir, Alexandru, Cuevas, Jacob, Badea, Tudor C., Muresanu, Dafin F., Rus, Violeta, Rus, Horea

“…Recent advances in understanding the pathogenesis of multiple sclerosis (MS) have brought into the spotlight the major role played by reactive astrocytes in…”
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Modality-based organization of ascending somatosensory axons in the direct dorsal column pathway by Niu, Jingwen, Ding, Long, Li, Jian J, Kim, Hyukmin, Liu, Jiakun, Li, Haipeng, Moberly, Andrew, Badea, Tudor C, Duncan, Ian D, Son, Young-Jin, Scherer, Steven S, Luo, Wenqin

“…The long-standing doctrine regarding the functional organization of the direct dorsal column (DDC) pathway is the "somatotopic map" model, which suggests that…”
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A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction by Keenan, William Thomas, Rupp, Alan C, Ross, Rachel A, Somasundaram, Preethi, Hiriyanna, Suja, Wu, Zhijian, Badea, Tudor C, Robinson, Phyllis R, Lowell, Bradford B, Hattar, Samer S

“…Rapid and stable control of pupil size in response to light is critical for vision, but the neural coding mechanisms remain unclear. Here, we investigated the…”
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Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification by Shi, Melody, Kumar, Sumit R, Motajo, Oluwaseyi, Kretschmer, Friedrich, Mu, Xiuqian, Badea, Tudor C

“…Visual information is conveyed from the retina to the brain via 15-20 Retinal Ganglion Cell (RGC) types. The developmental mechanisms by which RGC types…”
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New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling by Badea, Tudor C, Hua, Zhong L, Smallwood, Philip M, Williams, John, Rotolo, Thomas, Ye, Xin, Nathans, Jeremy

“…Pharmacologic control of Cre-mediated recombination using tamoxifen-dependent activation of a Cre-estrogen receptor ligand binding domain fusion protein…”
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Novel Heterotypic Rox Sites for Combinatorial Dre Recombination Strategies by Chuang, Katherine, Nguyen, Eileen, Sergeev, Yuri, Badea, Tudor C

“…Site-specific recombinases (SSRs) such as Cre are widely used in gene targeting and genetic approaches for cell labeling and manipulation. They mediate DNA…”
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RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis by Tatomir, Alexandru, Beltrand, Austin, Nguyen, Vinh, Boodhoo, Dallas, Mekala, Armugam, Cudrici, Cornelia, Badea, Tudor C, Muresanu, Dafin F, Rus, Violeta, Rus, Horea

“…Astrocytes are increasingly recognized as critical contributors to multiple sclerosis pathogenesis. We have previously shown that lack of Response Gene to…”
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RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis by Tatomir, Alexandru, Beltrand, Austin, Nguyen, Vinh, Courneya, Jean-Paul, Boodhoo, Dallas, Cudrici, Cornelia, Muresanu, Dafin F, Rus, Violeta, Badea, Tudor C, Rus, Horea

“…Response Gene to Complement 32 (RGC-32) is an important mediator of the TGF-β signaling pathway, and an increasing amount of evidence implicates this protein…”
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RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis by Tatomir, Alexandru, Tegla, Cosmin A., Martin, Alvaro, Boodhoo, Dallas, Nguyen, Vinh, Sugarman, Adam J., Mekala, Armugam, Anselmo, Freidrich, Talpos-Caia, Anamaria, Cudrici, Cornelia, Badea, Tudor C., Rus, Violeta, Rus, Horea

“…Extracellular matrix (ECM) deposition in active demyelinating multiple sclerosis (MS) lesions may impede axonal regeneration and can modify immune reactions…”
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Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse by Kiyama, Takae, Long, Ye, Chen, Ching-Kang, Whitaker, Christopher M., Shay, Allison, Wu, Hongyu, Badea, Tudor C., Mohsenin, Amir, Parker-Thornburg, Jan, Klein, William H., Mills, Stephen L., Massey, Stephen C., Mao, Chai-An

“…In the mouse retina, more than 30 retinal ganglion cell (RGC) subtypes have been classified based on a combined metric of morphological and functional…”
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Pou4f1-Tbr1 transcriptional cascade controls the formation of Jam2-expressing retinal ganglion cells by Kiyama, Takae, Altay, Halit Y, Badea, Tudor C, Mao, Chai-An

“…More than 40 retinal ganglion cell (RGC) subtypes have been categorized in mouse based on their morphologies, functions, and molecular features. Among these…”
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A Noninvasive Genetic/Pharmacologic Strategy for Visualizing Cell Morphology and Clonal Relationships in the Mouse by Badea, Tudor C, Wang, Yanshu, Nathans, Jeremy

“…Analysis of cellular morphology is the most general approach to neuronal classification. With the increased use of genetically engineered mice, there is a…”
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