Search Results - "Badea, Tudor"
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Molecular studies into cell biological role of Copine-4 in Retinal Ganglion Cells
Published in PloS one (30-11-2021)“…The molecular mechanisms underlying morphological diversity in retinal cell types are poorly understood. We have previously reported that several members of…”
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Layer-Specific Developmentally Precise Axon Targeting of Transient Suppressed-by-Contrast Retinal Ganglion Cells
Published in The Journal of neuroscience (21-09-2022)“…The mouse retina encodes diverse visual features in the spike trains of >40 retinal ganglion cell (RGC) types. Each RGC type innervates a specific subset of…”
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3
Differential expression and subcellular localization of Copines in mouse retina
Published in Journal of comparative neurology (1911) (01-10-2019)“…Combinatorial expression of Brn3 transcription factors is required for the development of cell‐specific morphologies in retinal ganglion cells (RGCs). The…”
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Class 5 Transmembrane Semaphorins Control Selective Mammalian Retinal Lamination and Function
Published in Neuron (Cambridge, Mass.) (11-08-2011)“…In the vertebrate retina, neurites from distinct neuronal cell types are constrained within the plexiform layers, allowing for establishment of retinal…”
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A system to measure the Optokinetic and Optomotor response in mice
Published in Journal of neuroscience methods (30-12-2015)“…•A novel system for automated detection of Optomotor and Optokinetic responses under identical stimulation conditions reveals parallels between the two…”
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Distinct Roles of Transcription Factors Brn3a and Brn3b in Controlling the Development, Morphology, and Function of Retinal Ganglion Cells
Published in Neuron (Cambridge, Mass.) (26-03-2009)“…Transcriptional regulatory networks that control the morphologic and functional diversity of mammalian neurons are still largely undefined. Here we dissect the…”
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Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina
Published in The Journal of neuroscience (02-03-2016)“…Microglia, the principal resident immune cell of the CNS, exert significant influence on neurons during development and in pathological situations. However, if…”
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Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization
Published in Cell (16-10-2009)“…Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5…”
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Genetic interactions between Brn3 transcription factors in retinal ganglion cell type specification
Published in PloS one (08-10-2013)“…Visual information is conveyed from the retina to the brain via 15-20 Retinal Ganglion Cell (RGC) types. The developmental mechanisms by which RGC types…”
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Tamoxifen Provides Structural and Functional Rescue in Murine Models of Photoreceptor Degeneration
Published in The Journal of neuroscience (22-03-2017)“…Photoreceptor degeneration is a cause of irreversible vision loss in incurable blinding retinal diseases including retinitis pigmentosa (RP) and atrophic…”
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11
Role of RGC-32 in multiple sclerosis and neuroinflammation – few answers and many questions
Published in Frontiers in immunology (12-09-2022)“…Recent advances in understanding the pathogenesis of multiple sclerosis (MS) have brought into the spotlight the major role played by reactive astrocytes in…”
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Melanopsin cells are the principal conduits for rod-cone input to non-image-forming vision
Published in Nature (01-05-2008)“…Rod and cone photoreceptors detect light and relay this information through a multisynaptic pathway to the brain by means of retinal ganglion cells (RGCs)…”
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13
Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina
Published in Nature (London) (10-02-2011)“…Molecular cue in the developing retina The retina is a laminated structure made up of several different cellular subtypes, interconnected according to a…”
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14
New mouse lines for the analysis of neuronal morphology using CreER(T)/loxP-directed sparse labeling
Published in PloS one (16-11-2009)“…Pharmacologic control of Cre-mediated recombination using tamoxifen-dependent activation of a Cre-estrogen receptor ligand binding domain fusion protein…”
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RGC-32′ dual role in smooth muscle cells and atherogenesis
Published in Clinical immunology (Orlando, Fla.) (01-05-2022)“…Proliferation of endothelial cells (EC) and smooth muscle cells (SMC) is a critical process in atherosclerosis. Here, we investigated the involvement of…”
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RGC-32 mediates proinflammatory and profibrotic pathways in immune-mediated kidney disease
Published in Clinical immunology (Orlando, Fla.) (01-08-2024)“…Systemic lupus erythematosus is an autoimmune disease that results in immune-mediated damage to kidneys and other organs. We investigated the role of response…”
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Modality-based organization of ascending somatosensory axons in the direct dorsal column pathway
Published in The Journal of neuroscience (06-11-2013)“…The long-standing doctrine regarding the functional organization of the direct dorsal column (DDC) pathway is the "somatotopic map" model, which suggests that…”
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A visual circuit uses complementary mechanisms to support transient and sustained pupil constriction
Published in eLife (26-09-2016)“…Rapid and stable control of pupil size in response to light is critical for vision, but the neural coding mechanisms remain unclear. Here, we investigated the…”
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NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain
Published in Molecular cell (18-11-2021)“…The heterogeneous family of complexes comprising Polycomb repressive complex 1 (PRC1) is instrumental for establishing facultative heterochromatin that is…”
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Characterization of Tbr2‐expressing retinal ganglion cells
Published in Journal of comparative neurology (1911) (01-10-2021)“…The mammalian retina contains more than 40 retinal ganglion cell (RGC) subtypes based on their unique morphologies, functions, and molecular profiles. Among…”
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