Search Results - "Badder, Luned M"

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin by Krastev, Dragomir B., Li, Shudong, Sun, Yilun, Wicks, Andrew J., Hoslett, Gwendoline, Weekes, Daniel, Badder, Luned M., Knight, Eleanor G., Marlow, Rebecca, Pardo, Mercedes Calvo, Yu, Lu, Talele, Tanaji T., Bartek, Jiri, Choudhary, Jyoti S., Pommier, Yves, Pettitt, Stephen J., Tutt, Andrew N. J., Ramadan, Kristijan, Lord, Christopher J.

“…Poly (ADP-ribose) polymerase (PARP) inhibitors elicit antitumour activity in homologous recombination-defective cancers by trapping PARP1 in a chromatin-bound…”
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3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors by Badder, Luned M, Hollins, Andrew J, Herpers, Bram, Yan, Kuan, Ewan, Kenneth B, Thomas, Mairian, Shone, Jennifer R, Badder, Delyth A, Naven, Marc, Ashelford, Kevin E, Hargest, Rachel, Clarke, Alan R, Esdar, Christina, Buchstaller, Hans-Peter, Treherne, J. Mark, Boj, Sylvia, Ramezanpour, Bahar, Wienke, Dirk, Price, Leo S, Shaw, Paul H, Dale, Trevor C

“…Aberrant activation of the Wnt signalling pathway is required for tumour initiation and survival in the majority of colorectal cancers. The development of…”
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Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5NULL-A20 by Davies, James A., Marlow, Gareth, Uusi-Kerttula, Hanni K., Seaton, Gillian, Piggott, Luke, Badder, Luned M., Clarkson, Richard W. E., Chester, John D., Parker, Alan L.

“…We previously developed a refined, tumor-selective adenovirus, Ad5NULL-A20, harboring tropism ablating mutations in each major capsid protein, to ablate all…”
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A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications by Bliss, Carly M., Hulin-Curtis, Sarah L., Williams, Marta, Marušková, Mahulena, Davies, James A., Statkute, Evelina, Baker, Alexander T., Stack, Louise, Kerstetter, Lucas, Kerr-Jones, Lauren E., Milward, Kate F., Russell, Gabrielle, George, Sarah J., Badder, Luned M., Stanton, Richard J., Coughlan, Lynda, Humphreys, Ian R., Parker, Alan L.

“…Adenoviruses (Ads) have demonstrated significant success as replication-deficient (RD) viral vectored vaccines, as well as broad potential across gene therapy…”
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Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer by Yeow, Zhong Y., Lambrus, Bramwell G., Marlow, Rebecca, Zhan, Kevin H., Durin, Mary-Anne, Evans, Lauren T., Scott, Phillip M., Phan, Thao, Park, Elizabeth, Ruiz, Lorena A., Moralli, Daniela, Knight, Eleanor G., Badder, Luned M., Novo, Daniela, Haider, Syed, Green, Catherine M., Tutt, Andrew N. J., Lord, Christopher J., Chapman, J. Ross, Holland, Andrew J.

“…Genomic instability is a hallmark of cancer, and has a central role in the initiation and development of breast cancer 1 , 2 . The success of poly-ADP ribose…”
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The αvβ6 integrin specific virotherapy, Ad5NULL-A20.FCU1, selectively delivers potent “in-tumour” chemotherapy to pancreatic ductal adenocarcinoma by Badder, Luned M., Davies, James A., Meniel, Valerie S., Marušková, Mahulena, Salvador-Barbero, Beatriz, Bayliss, Rebecca J., Phesse, Toby J., Hogan, Catherine, Parker, Alan L.

“…Background Pancreatic ductal adenocarcinoma (PDAC) represent an unmet clinical need. Approximately 90% of PDACs express high levels of αvβ6 integrin. We have…”
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Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance by Zatreanu, Diana, Robinson, Helen M. R., Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert A., Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall M. B., Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luned M., Novo, Daniela, Knight, Eleanor G., Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Bot, Chris, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Ewings, Katherine, Krajewski, Wojciech, MacDonald, Ellen, McCarron, Hollie, Pang, Leon, Pedder, Chris, Rigoreau, Laurent, Swarbrick, Martin, Wheatley, Ed, Willis, Simon, Wong, Ai Ching, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew, Boulton, Simon J., Higgins, Geoff S., Pettitt, Stephen J., Smith, Graeme C. M., Lord, Christopher J.

“…To identify approaches to target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight (MW), allosteric…”
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The αvβ6 integrin specific virotherapy, Ad5 NULL -A20.FCU1, selectively delivers potent "in-tumour" chemotherapy to pancreatic ductal adenocarcinoma by Badder, Luned M, Davies, James A, Meniel, Valerie S, Marušková, Mahulena, Salvador-Barbero, Beatriz, Bayliss, Rebecca J, Phesse, Toby J, Hogan, Catherine, Parker, Alan L

“…Pancreatic ductal adenocarcinoma (PDAC) represent an unmet clinical need. Approximately 90% of PDACs express high levels of αvβ6 integrin. We have previously…”
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Exploiting TRIM37-driven centrosome dysfunction to kill breast cancer cells by Yeow, Zhong Y., Lambrus, Bramwell G., Marlow, Rebecca, Zhan, Kevin H., Durin, Mary-Anne, Evans, Lauren T., Scott, Phillip M., Phan, Thao, Park, Elizabeth, Ruiz, Lorena A., Moralli, Daniela, Knight, Eleanor G., Badder, Luned M., Novo, Daniela, Haider, Syed, Green, Catherine M., Tutt, Andrew NJ, Lord, Christopher J, Chapman, J. Ross, Holland, Andrew J.

“…Genomic instability (GI) is a hallmark of cancer and plays a central role in breast cancer initiation and development 1 , 2 . The success of Poly-ADP ribose…”
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Abstract P056: Polθ inhibitors elicit BRCA -gene synthetic lethality and target PARP inhibitor resistance by Zatreanu, Diana A., Robinson, Helen M. R., Alkhatib, Omar, Boursier, Marie, Finch, Harry, Geo, Lerin, Grande, Diego, Grinkevich, Vera, Heald, Robert, Langdon, Sophie, Majithiya, Jayesh, McWhirter, Claire, Martin, Niall M. B., Moore, Shaun, Neves, Joana, Rajendra, Eeson, Ranzani, Marco, Schaedler, Theresia, Stockley, Martin, Wiggins, Kimberley, Brough, Rachel, Sridhar, Sandhya, Gulati, Aditi, Shao, Nan, Badder, Luned M, Novo, Daniela, Knight, Eleanor G., Marlow, Rebecca, Haider, Syed, Callen, Elsa, Hewitt, Graeme, Schimmel, Joost, Prevo, Remko, Alli, Christina, Ferdinand, Amanda, Bell, Cameron, Blencowe, Peter, Calder, Mathew, Charles, Mark, Curry, Jayne, Ekwuru, Tennyson, Ewings, Katherine, Nussenzweig, Andre, Tijsterman, Marcel, Tutt, Andrew, Boulton, Simon J., Higgins, Geoff S., Pettitt, Steve, Smith, Graeme C. M., Lord, Christopher J.

“…Abstract To target DNA repair vulnerabilities in cancer, we discovered nanomolar potent, selective, low molecular weight, allosteric inhibitors of the…”
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Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5 NULL -A20 by Davies, James A, Marlow, Gareth, Uusi-Kerttula, Hanni K, Seaton, Gillian, Piggott, Luke, Badder, Luned M, Clarkson, Richard W E, Chester, John D, Parker, Alan L

“…We previously developed a refined, tumor-selective adenovirus, Ad5 -A20, harboring tropism ablating mutations in each major capsid protein, to ablate all…”
Get full text