Search Results - "Bacus, Sarah S."

Synergistic Down-Regulation of Receptor Tyrosine Kinases by Combinations of mAbs: Implications for Cancer Immunotherapy by Friedman, Lilach M., Rinon, Ariel, Schechter, Bilha, Lyass, Ljuba, Lavi, Sara, Bacus, Sarah S., Sela, Michael, Yarden, Yosef

“…mAbs to receptor tyrosine kinases such as EGF receptor/ErbB-1 and HER2/ErbB-2 inhibit the tumorigenic growth of certain cancer cells, but although recombinant…”
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Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells by Spector, Neil L, Yarden, Yosef, Smith, Bradley, Lyass, Ljuba, Trusk, Patricia, Pry, Karen, Hill, Jason E, Xia, Wenle, Seger, Rony, Bacus, Sarah S

“…The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes, and its inhibition may explain the increased incidence…”
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Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells by Shell, Scott A, Lyass, Ljuba, Trusk, Patricia B, Pry, Karen J, Wappel, Robert L, Bacus, Sarah S

“…ErbB2 targeted therapies represent an attractive strategy in breast cancer. Herceptin, an anti-ErbB2 monoclonal antibody, is an approved treatment for patients…”
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Epigen, the Last Ligand of ErbB Receptors, Reveals Intricate Relationships between Affinity and Mitogenicity by Kochupurakkal, Bose S., Harari, Daniel, Di-Segni, Ayelet, Maik-Rachline, Galia, Lyass, Ljuba, Gur, Gal, Kerber, Gabriele, Citri, Ami, Lavi, Sara, Eilam, Raya, Chalifa-Caspi, Vered, Eshhar, Zelig, Pikarsky, Eli, Pinkas-Kramarski, Ronit, Bacus, Sarah S., Yarden, Yosef

“…Four ErbB receptors and multiple growth factors sharing an epidermal growth factor (EGF) motif underlie transmembrane signaling by the ErbB family in…”
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KRAS mutation status is associated with enhanced dependency on folate metabolism pathways in non-small cell lung cancer cells by Moran, Diarmuid M, Trusk, Patricia B, Pry, Karen, Paz, Keren, Sidransky, David, Bacus, Sarah S

“…KRAS gene mutation is linked to poor prognosis and resistance to therapeutics in non-small cell lung cancer (NSCLC). In this study, we have explored the…”
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A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration by Carvalho, Silvia, Liao, Yi-Chun, Spector, Neil L, Bacus, Sarah S, Amariglio, Ninette, Lindzen, Moshit, Lyass, Ljuba, Yarden, Yosef, Tarcic, Gabi, Trusk, Patricia, Citri, Ami, Lo, Su Hao, Rechavi, Gideon, Jacob-Hirsch, Jasmine, Ben-Chetrit, Nir, Katz, Menachem, Milanezi, Fernanda, Avraham, Roi, Schmitt, Fernando, Lyass, Asya, Shay, Tal, Lavi, Sara, Amit, Ido

“…Cell migration driven by the epidermal growth factor receptor (EGFR) propels morphogenesis and involves reorganization of the actin cytoskeleton. Although de…”
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Cyclin E and Survival in Patients with Breast Cancer by Keyomarsi, Khandan, Tucker, Susan L, Buchholz, Thomas A, Callister, Matthew, Ding, Ye, Hortobagyi, Gabriel N, Bedrosian, Isabelle, Knickerbocker, Christopher, Toyofuku, Wendy, Lowe, Michael, Herliczek, Thaddeus W, Bacus, Sarah S

“…The level of cyclin E, part of a molecular network that controls the cell cycle, is increased in breast-cancer cell lines. In breast-cancer tissue, high levels…”
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Taxol-induced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53 by BACUS, Sarah S, GUDKOV, Andrei V, LOWE, Michael, LYASS, Ljuba, YUNG, Yuval, KOMAROV, Andrei P, KEYOMARSI, Khandan, YARDEN, Yosef, SEGER, Rony

“…The anti-cancer agent paclitaxel (Taxol) stabilizes microtubules leading to G2/M cell cycle arrest and apoptotic cell death. In order to analyse the molecular…”
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The oncogenic ErbB-2/ErbB-3 heterodimer is a surrogate receptor of the epidermal growth factor and betacellulin by PINKAS-KRAMARSKI, R, LENFERINK, A. E. G, BACUS, S. S, LYASS, L, VAN DE POLL, M. L. M, KLAPPER, L. N, TZAHAR, E, SELA, M, VAN ZOELEN, E. J. J, YARDEN, Y

“…The ErbB-1 receptor tyrosine kinase binds to six different growth factors, whose prototype is the epidermal growth factor (EGF). Two homologous epithelial…”
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Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors by Xia, Wenle, Liu, Zuguo, Zong, Rongrong, Liu, Leihua, Zhao, Sumin, Bacus, Sarah S, Mao, Yubin, He, Jia, Wulfkuhle, Julia D, Petricoin, 3rd, Emanuel F, Osada, Takuya, Yang, Xiao-Yi, Hartman, Zachary C, Clay, Timothy M, Blackwell, Kimberly L, Lyerly, Herbert K, Spector, Neil L

“…ErbB2 tyrosine kinase inhibitors (TKI) block tyrosine autophosphorylation and activation of the full-length transmembrane ErbB2 receptor (p185(ErbB2)). In…”
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Expression of erbB/HER receptors, heregulin and P38 in primary breast cancer using quantitative immunohistochemistry by Esteva, F J, Hortobagyi, G N, Sahin, A A, Smith, T L, Chin, D M, Liang, S Y, Pusztai, L, Buzdar, A U, Bacus, S S

“…The purpose of this study was to investigate the frequency of expression of the erbB/HER family of growth factor receptors, their ligand heregulin, and the two…”
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Prognostic significance of phosphorylated P38 mitogen‐activated protein kinase and HER‐2 expression in lymph node‐positive breast carcinoma by Esteva, Francisco J., Sahin, Aysegul A., Smith, Terry L., Yang, Ying, Pusztai, Lajos, Nahta, Rita, Buchholz, Thomas A., Buzdar, Aman U., Hortobagyi, Gabriel N., Bacus, Sarah S.

“…BACKGROUND Chemotherapy‐induced p38 mitogen‐activated protein kinase (MAPK) phosphorylation reportedly leads to increased apoptosis in breast carcinoma cells…”
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AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival by BACUS, Sarah S, ALTOMARE, Deborah A, LYASS, Ljuba, DOT MON CHIN, FARRELL, Michael P, GUROVA, Katerina, GUDKOV, Andrei, TESTA, Joseph R

“…Amplification or overexpression of the HER-2/neu gene in breast cancers is associated with aggressive behavior and resistance to therapeutic regimens. The…”
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Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo by Komarova, Elena A., Chernov, Mikhail V., Franks, Roberta, Wang, Kaihua, Armin, Gabriella, Zelnick, Carolyn R., Chin, Dot M., Bacus, Sarah S., Stark, George R., Gudkov, Andrei V.

“…To analyze the involvement of p53‐dependent transcriptional activation in normal development and in response to DNA damage in vivo, we created transgenic mice…”
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Epiregulin Is a Potent Pan-ErbB Ligand That Preferentially Activates Heterodimeric Receptor Complexes by Shelly, Maya, Pinkas-Kramarski, Ronit, Guarino, Bradley C., Waterman, Hadassa, Wang, Ling-Mei, Lyass, Ljuba, Alimandi, Mauricio, Kuo, Angera, Bacus, Sarah S., Pierce, Jacalyn H., Andrews, Glenn C., Yarden, Yosef

“…The ErbB signaling network consists of four transmembrane receptor tyrosine kinases and more than a dozen ligands sharing an epidermal growth factor (EGF)…”
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ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network by Pinkas-Kramarski, Ronit, Shelly, Maya, Guarino, Bradley C., Wang, Ling Mei, Lyass, Ljuba, Alroy, Iris, Alamandi, Mauricio, Kuo, Angera, Moyer, James D., Lavi, Sara, Eisenstein, Miriam, Ratzkin, Barry J., Seger, Rony, Bacus, Sarah S., Pierce, Jacalyn H., Andrews, Glenn C., Yarden, Yosef

“…AUTHOR'S CORRECTION ( vol. 19 , p. 8695 ) ERRATUM ( vol. 18 , p. 7602 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content…”
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Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit by Wen, D, Peles, E, Cupples, R, Suggs, S V, Bacus, S S, Luo, Y, Trail, G, Hu, S, Silbiger, S M, Levy, R B

“…We recently reported that a 44 kd glycoprotein secreted by transformed fibroblasts stimulates tyrosine phosphorylation of the product of the neu proto-oncogene…”
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Suppressed transformation and induced differentiation of HER-2/neu-overexpressing breast cancer cells by emodin by LISHA ZHANG, CHING-JER CHANG, BACUS, S. S, MIEN-CHIE HUNG

“…The amplification and overexpression of the HER-2/neu proto-oncogene, which encodes the tyrosine kinase receptor p185neu, have been observed frequently in…”
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An Immunological Approach Reveals Biological Differences between the Two NDF/Heregulin Receptors, ErbB-3 and ErbB-4 (∗) by Chen, Xiaomei, Levkowitz, Gil, Tzahar, Eldad, Karunagaran, Devarajan, Lavi, Sara, Ben-Baruch, Noa, Leitner, Orith, Ratzkin, Barry J., Bacus, Sarah S., Yarden, Yosef

“…The group of subtype I transmembrane tyrosine kinases includes the epidermal growth factor (EGF) receptor (ErbB-1), an orphan receptor (ErbB-2), and two…”
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Tumor-inhibitory monoclonal antibodies to the HER-2/neu receptor induce differentiation of human breast cancer cells by BACUS, S. S, STANCOVSKI, I, HUBERMAN, E, CHIN, D, HURWITZ, E, MILLS, G. B, ULLRICH, A, SELA, M, YARDEN, Y

“…The HER-2/neu protooncogene (also called erbB-2) encodes a tyrosine kinase receptor for a polypeptide growth-regulatory molecule. Amplification and…”
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