Search Results - "Bacon, Sebastian C.J."

HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform by Bhaskaran, Krishnan, Rentsch, Christopher T, MacKenna, Brian, Schultze, Anna, Mehrkar, Amir, Bates, Chris J, Eggo, Rosalind M, Morton, Caroline E, Bacon, Sebastian C J, Inglesby, Peter, Douglas, Ian J, Walker, Alex J, McDonald, Helen I, Cockburn, Jonathan, Williamson, Elizabeth J, Evans, David, Forbes, Harriet J, Curtis, Helen J, Hulme, William J, Parry, John, Hester, Frank, Harper, Sam, Evans, Stephen J W, Smeeth, Liam, Goldacre, Ben

“…Whether HIV infection is associated with risk of death due to COVID-19 is unclear. We aimed to investigate this association in a large-scale population-based…”
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Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe covid-19 outcomes in patients in the community: observational cohort study with the OpenSAFELY platform by Zheng, Bang, Green, Amelia C A, Tazare, John, Curtis, Helen J, Fisher, Louis, Nab, Linda, Schultze, Anna, Mahalingasivam, Viyaasan, Parker, Edward P K, Hulme, William J, Bacon, Sebastian C J, DeVito, Nicholas J, Bates, Christopher, Evans, David, Inglesby, Peter, Drysdale, Henry, Davy, Simon, Cockburn, Jonathan, Morton, Caroline E, Hickman, George, Ward, Tom, Smith, Rebecca M, Parry, John, Hester, Frank, Harper, Sam, Mehrkar, Amir, Eggo, Rosalind M, Walker, Alex J, Evans, Stephen J W, Douglas, Ian J, MacKenna, Brian, Goldacre, Ben, Tomlinson, Laurie A

“…To compare the effectiveness of sotrovimab (a neutralising monoclonal antibody) with molnupiravir (an antiviral) in preventing severe outcomes of covid-19 in…”
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Comparative effectiveness of BNT162b2 versus mRNA-1273 covid-19 vaccine boosting in England: matched cohort study in OpenSAFELY-TPP by Hulme, William J, Horne, Elsie M F, Parker, Edward P K, Keogh, Ruth H, Williamson, Elizabeth J, Walker, Venexia, Palmer, Tom M, Curtis, Helen J, Walker, Alex J, Andrews, Colm D, Mehrkar, Amir, Morley, Jessica, MacKenna, Brian, Bacon, Sebastian C J, Goldacre, Ben, Hernán, Miguel A, Sterne, Jonathan A C

“…To compare the effectiveness of the BNT162b2 mRNA (Pfizer-BioNTech) and mRNA-1273 (Moderna) covid-19 vaccines during the booster programme in England. Matched…”
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The impact of lidocaine plaster prescribing reduction strategies: A comparison of two national health services in Europe by Mattsson, Molly, Boland, Fiona, Kirke, Ciara, Flood, Michelle, Wallace, Emma, Walsh, Mary E., Corrigan, Derek, Fahey, Tom, Croker, Richard, Bacon, Sebastian C. J., Inglesby, Peter, Evans, David, Goldacre, Ben, MacKenna, Brian, Moriarty, Frank

“…Aims In 2017, two distinct interventions were implemented in Ireland and England to reduce prescribing of lidocaine medicated plasters. In Ireland,…”
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The impact of COVID-19 on antibiotic prescribing in primary care in England: Evaluation and risk prediction of appropriateness of type and repeat prescribing by Zhong, Xiaomin, Pate, Alexander, Yang, Ya-Ting, Fahmi, Ali, Ashcroft, Darren M., Goldacre, Ben, MacKenna, Brian, Mehrkar, Amir, Bacon, Sebastian C.J., Massey, Jon, Fisher, Louis, Inglesby, Peter, Hand, Kieran, van Staa, Tjeerd, Palin, Victoria

“…This study aimed to predict risks of potentially inappropriate antibiotic type and repeat prescribing and assess changes during COVID-19. With the approval of…”
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The impact of COVID‐19 on medication reviews in English primary care. An OpenSAFELY‐TPP analysis of 20 million adult electronic health records by Wood, Christopher, Speed, Victoria, Fisher, Louis, Curtis, Helen J., Schaffer, Andrea L., Walker, Alex J., Croker, Richard, Brown, Andrew D., Cunningham, Christine, Hulme, William J., Andrews, Colm D., Butler‐Cole, Ben F. C., Evans, David, Inglesby, Peter, Dillingham, Iain, Bacon, Sebastian C. J., Davy, Simon, Ward, Tom, Hickman, George, Bridges, Lucy, O'Dwyer, Thomas, Maude, Steven, Smith, Rebecca M., Mehrkar, Amir, Bates, Chris, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Goldacre, Ben, MacKenna, Brian

“…Aims The COVID‐19 pandemic caused significant disruption to routine activity in primary care. Medication reviews are an important primary care activity…”
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OpenSAFELY NHS Service Restoration Observatory 2: changes in primary care clinical activity in England during the COVID-19 pandemic by Curtis, Helen J, MacKenna, Brian, Wiedemann, Milan, Fisher, Louis, Croker, Richard, Morton, Caroline E, Inglesby, Peter, Walker, Alex J, Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian Cj, Hickman, George, Evans, David, Ward, Tom, Davy, Simon, Hulme, William J, Macdonald, Orla, Conibere, Robin, Lewis, Tom, Myers, Martin, Wanninayake, Shamila, Collison, Kiren, Drury, Charles, Samuel, Miriam, Sood, Harpreet, Cipriani, Andrea, Fazel, Seena, Sharma, Manuj, Baqir, Wasim, Bates, Chris, Parry, John, Goldacre, Ben

“…The COVID-19 pandemic has disrupted healthcare activity across a broad range of clinical services. The NHS stopped non-urgent work in March 2020, later…”
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Comparative effectiveness of ChAdOx1 versus BNT162b2 covid-19 vaccines in health and social care workers in England: cohort study using OpenSAFELY by Hulme, William J, Williamson, Elizabeth J, Green, Amelia C A, Bhaskaran, Krishnan, McDonald, Helen I, Rentsch, Christopher T, Schultze, Anna, Tazare, John, Curtis, Helen J, Walker, Alex J, Tomlinson, Laurie A, Palmer, Tom, Horne, Elsie M F, MacKenna, Brian, Morton, Caroline E, Mehrkar, Amir, Morley, Jessica, Fisher, Louis, Bacon, Sebastian C J, Evans, David, Inglesby, Peter, Hickman, George, Davy, Simon, Ward, Tom, Croker, Richard, Eggo, Rosalind M, Wong, Angel Y S, Mathur, Rohini, Wing, Kevin, Forbes, Harriet, Grint, Daniel J, Douglas, Ian J, Evans, Stephen J W, Smeeth, Liam, Bates, Chris, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Sterne, Jonathan A C, Hernán, Miguel A, Goldacre, Ben

“…To compare the effectiveness of the BNT162b2 mRNA (Pfizer-BioNTech) and the ChAdOx1 (Oxford-AstraZeneca) covid-19 vaccines against infection and covid-19…”
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Changes in COVID-19-related mortality across key demographic and clinical subgroups in England from 2020 to 2022: a retrospective cohort study using the OpenSAFELY platform by Nab, Linda, Parker, Edward P K, Andrews, Colm D, Hulme, William J, Fisher, Louis, Morley, Jessica, Mehrkar, Amir, MacKenna, Brian, Inglesby, Peter, Morton, Caroline E, Bacon, Sebastian C J, Hickman, George, Evans, David, Ward, Tom, Smith, Rebecca M, Davy, Simon, Dillingham, Iain, Maude, Steven, Butler-Cole, Ben F C, O’Dwyer, Thomas, Stables, Catherine L, Bridges, Lucy, Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Zheng, Bang, Williamson, Elizabeth J, Eggo, Rosalind M, Evans, Stephen J W, Goldacre, Ben, Tomlinson, Laurie A, Walker, Alex J

“…COVID-19 has been shown to differently affect various demographic and clinical population subgroups. We aimed to describe trends in absolute and relative…”
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The impact of the COVID-19 pandemic on the treatment of common infections in primary care and the change to antibiotic prescribing in England by Yang, Ya-Ting, Zhong, Xiaomin, Fahmi, Ali, Watts, Simon, Ashcroft, Darren M, Massey, Jon, Fisher, Louis, MacKenna, Brian, Mehrkar, Amir, Bacon, Sebastian C J, Goldacre, Ben, Hand, Kieran, van Staa, Tjeerd, Palin, Victoria

“…There is concern that the COVID-19 pandemic altered the management of common infections in primary care. This study aimed to evaluate infection-coded…”
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Impact of long COVID on health-related quality-of-life: an OpenSAFELY population cohort study using patient-reported outcome measures (OpenPROMPT) by Carlile, Oliver, Briggs, Andrew, Henderson, Alasdair D., Butler-Cole, Ben F.C., Tazare, John, Tomlinson, Laurie A., Marks, Michael, Jit, Mark, Lin, Liang-Yu, Bates, Chris, Parry, John, Bacon, Sebastian C.J., Dillingham, Iain, Dennison, William A., Costello, Ruth E., Walker, Alex J., Hulme, William, Goldacre, Ben, Mehrkar, Amir, MacKenna, Brian, Walker, Alex, Green, Amelia, Mehrkar, Amir, Schaffer, Andrea, Brown, Andrew, Goldacre, Ben, Butler-Cole, Ben, MacKenna, Brian, Morton, Caroline, Walters, Caroline, Stables, Catherine, Cunningham, Christine, Wood, Christopher, Andrews, Colm, Hickman, George, Curtis, Helen, Drysdale, Henry, Dillingham, Iain, Morley, Jessica, Massey, Jon, Nab, Linda, Hopcroft, Lisa, Fisher, Louis, Wiedemann, Milan, DeVito, Nicholas, Macdonald, Orla, Inglesby, Peter, Smith, Rebecca, Croker, Richard, Park, Robin, Higgins, Rose, Bacon, Sebastian, Davy, Simon, Maude, Steven, O'Dwyer, Thomas, Ward, Tom, Speed, Victoria, Hulme, William, Hart, Liam, Stokes, Pete, Costello, Ruth, Cowling, Thomas, Douglas, Ian, Eggo, Rosalind, Evans, Stephen, Forbes, Harriet, Grieve, Richard, Herrett, Emily, Langan, Sinead, Mahalingasivam, Viyaasan, Mansfield, Kathryn, Mathur, Rohini, McDonald, Helen, Parker, Edward, Rentsch, Christopher, Schultze, Anna, Tazare, John, Tomlinson, Laurie, Walker, Jemma, Williamson, Elizabeth, Wing, Kevin, Wong, Angel, Zheng, Bang, Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, O'Hanlon, Shaun, Eavis, Alex, Jarvis, Richard, Avramov, Dima, Griffiths, Paul, Fowles, Aaron, Harrison, David, Khunti, Kamlesh, Sterne, Jonathan, Quint, Jennifer, Herrett, Emily, Eggo, Rosalind M.

“…Long COVID is a major problem affecting patient health, the health service, and the workforce. To optimise the design of future interventions against COVID-19,…”
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Clinical and health inequality risk factors for non-COVID-related sepsis during the global COVID-19 pandemic: a national case-control and cohort study by Zhong, Xiaomin, Ashiru-Oredope, Diane, Pate, Alexander, Martin, Glen P., Sharma, Anita, Dark, Paul, Felton, Tim, Lake, Claire, MacKenna, Brian, Mehrkar, Amir, Bacon, Sebastian C.J., Massey, Jon, Inglesby, Peter, Goldacre, Ben, Walker, Alex J., MacKenna, Brian, Inglesby, Peter, Goldacre, Ben, Curtis, Helen J., Morley, Jessica, Mehrkar, Amir, Bacon, Sebastian C.J., Hickman, George, Croker, Richard, Evans, David, Ward, Tom, DeVito, Nicholas J., Fisher, Louis, Green, Amelia C.A., Massey, Jon, Smith, Rebecca M., Hulme, William J., Davy, Simon, Andrews, Colm D., Hopcroft, Lisa E.M., Dillingham, Iain, Higgins, Rose, Cunningham, Christine, Wiedemann, Milan, Nab, Linda, Maude, Steven, Macdonald, Orla, Butler-Cole, Ben F.C., O'Dwyer, Thomas, Stables, Catherine L., Wood, Christopher, Brown, Andrew D., Speed, Victoria, Bridges, Lucy, Schaffer, Andrea L., Walters, Caroline E., Bates, Christopher, Cockburn, Jonathan, Parry, John, Hester, Frank, Harper, Sam, Hand, Kieran, Bladon, Sian, Cunningham, Neil, Gilham, Ellie, Brown, Colin S., Mirfenderesky, Mariyam, Palin, Victoria, van Staa, Tjeerd Pieter

“…Sepsis, characterised by significant morbidity and mortality, is intricately linked to socioeconomic disparities and pre-admission clinical histories. This…”
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Impact of long COVID on health-related quality-of-life: an OpenSAFELY population cohort study using patient-reported outcome measures (OpenPROMPT)Research in context by Oliver Carlile, Andrew Briggs, Alasdair D. Henderson, Ben F.C. Butler-Cole, John Tazare, Laurie A. Tomlinson, Michael Marks, Mark Jit, Liang-Yu Lin, Chris Bates, John Parry, Sebastian C.J. Bacon, Iain Dillingham, William A. Dennison, Ruth E. Costello, Alex J. Walker, William Hulme, Ben Goldacre, Amir Mehrkar, Brian MacKenna, Emily Herrett, Rosalind M. Eggo, Alex Walker, Amelia Green, Amir Mehrkar, Andrea Schaffer, Andrew Brown, Ben Goldacre, Ben Butler-Cole, Brian MacKenna, Caroline Morton, Caroline Walters, Catherine Stables, Christine Cunningham, Christopher Wood, Colm Andrews, David Evans, George Hickman, Helen Curtis, Henry Drysdale, Iain Dillingham, Jessica Morley, Jon Massey, Linda Nab, Lisa Hopcroft, Louis Fisher, Lucy Bridges, Milan Wiedemann, Nicholas DeVito, Orla Macdonald, Peter Inglesby, Rebecca Smith, Richard Croker, Robin Park, Rose Higgins, Sebastian Bacon, Simon Davy, Steven Maude, Thomas O'Dwyer, Tom Ward, Victoria Speed, William Hulme, Liam Hart, Pete Stokes, Krishnan Bhaskaran, Ruth Costello, Thomas Cowling, Ian Douglas, Rosalind Eggo, Stephen Evans, Harriet Forbes, Richard Grieve, Daniel Grint, Emily Herrett, Sinead Langan, Viyaasan Mahalingasivam, Kathryn Mansfield, Rohini Mathur, Helen McDonald, Edward Parker, Christopher Rentsch, Anna Schultze, Liam Smeeth, John Tazare, Laurie Tomlinson, Jemma Walker, Elizabeth Williamson, Kevin Wing, Angel Wong, Bang Zheng, Christopher Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Shaun O'Hanlon, Alex Eavis, Richard Jarvis, Dima Avramov, Paul Griffiths

“…Background: Long COVID is a major problem affecting patient health, the health service, and the workforce. To optimise the design of future interventions…”
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Data-Driven Identification of Unusual Prescribing Behavior: Analysis and Use of an Interactive Data Tool Using 6 Months of Primary Care Data From 6500 Practices in England by Hopcroft, Lisa Em, Massey, Jon, Curtis, Helen J, Mackenna, Brian, Croker, Richard, Brown, Andrew D, O'Dwyer, Thomas, Macdonald, Orla, Evans, David, Inglesby, Peter, Bacon, Sebastian Cj, Goldacre, Ben, Walker, Alex J

“…Approaches to addressing unwarranted variation in health care service delivery have traditionally relied on the prospective identification of activities and…”
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Identifying Patterns of Clinical Interest in Clinicians' Treatment Preferences: Hypothesis-free Data Science Approach to Prioritizing Prescribing Outliers for Clinical Review by MacKenna, Brian, Curtis, Helen J, Hopcroft, Lisa E M, Walker, Alex J, Croker, Richard, Macdonald, Orla, Evans, Stephen J W, Inglesby, Peter, Evans, David, Morley, Jessica, Bacon, Sebastian C J, Goldacre, Ben

“…Data analysis is used to identify signals suggestive of variation in treatment choice or clinical outcome. Analyses to date have generally focused on a…”
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