Search Results - "Bacon, PA"

The Spectrum of Wegener's Granulomatosis and Disease Relapse by Bacon, Paul A

“…Wegener's syndrome is a rare systemic disorder that involves multiple organs. Dr. Paul Bacon writes that uncovering the driving forces behind both the…”
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Autologous stem cell transplantation in the treatment of systemic sclerosis: report from the EBMT/EULAR Registry by Farge, D, Passweg, J, van Laar, J M, Marjanovic, Z, Besenthal, C, Finke, J, Peter, H H, Breedveld, F C, Fibbe, W E, Black, C, Denton, C, Koetter, I, Locatelli, F, Martini, A, Schattenberg, A V N, van den Hoogen, F, van de Putte, L, Lanza, F, Arnold, R, Bacon, P A, Bingham, S, Ciceri, F, Didier, B, Diez-Martin, J L, Emery, P, Feremans, W, Hertenstein, B, Hiepe, F, Luosujärvi, R, Leon Lara, A, Marmont, A, Martinez, A M, Pascual Cascon, H, Bocelli-Tyndall, C, Gluckman, E, Gratwohl, A, Tyndall, A

“…Objective: To analyse the durability of the responses after haematopoietic stem cell transplantation (HSCT) for severe systemic sclerosis (SSc) and determine…”
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Endothelial cell dysfunction in systemic vasculitis: new developments and therapeutic prospects by Bacon, P A

“…PURPOSE OF REVIEWThe role of the endothelium as an active player rather than a passive victim of inflammation has received considerable interest in…”
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Development and initial validation of the Vasculitis Damage Index for the standardized clinical assessment of damage in the systemic vasculitides by Exley, A R, Bacon, P A, Luqmani, R A, Kitas, G D, Gordon, C, Savage, C O, Adu, D

“…To develop and validate the Vasculitis Damage Index (VDI) for the standardized clinical assessment of damage in the systemic vasculitides. Using a nominal…”
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Nailfold capillary microscopy in healthy children and in childhood rheumatic diseases: a prospective single blind observational study by Dolezalova, P, Young, S P, Bacon, P A, Southwood, T R

“…Objectives: To develop an objective method of nailfold capillaroscopy (NFC), applicable to a wide age range of paediatric patients. To compare the…”
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Nomenclature of systemic vasculitides. Proposal of an international consensus conference by Jennette, J C, Falk, R J, Andrassy, K, Bacon, P A, Churg, J, Gross, W L, Hagen, E C, Hoffman, G S, Hunder, G G, Kallenberg, C G

“…The following are some of the conclusions and proposals made at the Chapel Hill Consensus Conference on the Nomenclature of Systemic Vasculitis. 1. Although…”
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Phase I/II trial of autologous stem cell transplantation in systemic sclerosis: procedure related mortality and impact on skin disease by Binks, M, Passweg, J R, Furst, D, McSweeney, P, Sullivan, K, Besenthal, C, Finke, J, Peter, H H, van Laar, J, Breedveld, F C, Fibbe, W E, Farge, D, Gluckman, E, Locatelli, F, Martini, A, van den Hoogen, F, van de Putte, L, Schattenberg, A V N, Arnold, R, Bacon, P A, Emery, P, Espigado, I, Hertenstein, B, Hiepe, F, Kashyap, A, Kötter, I, Marmont, A, Martinez, A, Pascual, M J, Gratwohl, A, Prentice, H G, Black, C, Tyndall, A

“…BACKGROUND Systemic sclerosis (SSc, scleroderma) in either its diffuse or limited skin forms has a high mortality when vital organs are affected. No treatment…”
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A disease severity scale for systemic sclerosis: development and testing by Medsger, Jr, T A, Silman, A J, Steen, V D, Black, C M, Akesson, A, Bacon, P A, Harris, C A, Jablonska, S, Jayson, M I, Jimenez, S A, Krieg, T, Leroy, E C, Maddison, P J, Russell, M L, Schachter, R K, Wollheim, F A, Zacharaie, H

“…To develop and test a severity scale for individual organ involvements in systemic sclerosis (SSc, scleroderma). An international study group completed the…”
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Birmingham Vasculitis Activity Score (BVAS) in systemic necrotizing vasculitis by Luqmani, R A, Bacon, P A, Moots, R J, Janssen, B A, Pall, A, Emery, P, Savage, C, Adu, D

“…The continuing morbidity of patients with vasculitis, despite the improved prognosis with aggressive therapy, underlines the need for accurate disease…”
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Diffuse endothelial dysfunction is common to ANCA associated systemic vasculitis and polyarteritis nodosa by Filer, A D, Gardner-Medwin, J M, Thambyrajah, J, Raza, K, Carruthers, D M, Stevens, R J, Liu, L, Lowe, S E, Townend, J N, Bacon, P A

“…Background: Excess cardiovascular mortality complicates systemic rheumatic disease, suggesting an accelerated atheromatous process, which it has been proposed…”
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Suppression of inflammation in primary systemic vasculitis restores vascular endothelial function : Lessons for atherosclerotic disease? by RAZA, K, THAMBYRAJAH, J, TOWNEND, J. N, EXLEY, A. R, HORTAS, C, FILER, A, CARRUTHERS, D. M, BACON, P. A

“…Chronic inflammatory rheumatic disorders are associated with excess cardiovascular mortality. This may result from arteriosclerosis following inflammatory…”
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Inhibition of T cell apoptosis in the rheumatoid synovium by Salmon, M, Scheel-Toellner, D, Huissoon, A P, Pilling, D, Shamsadeen, N, Hyde, H, D'Angeac, A D, Bacon, P A, Emery, P, Akbar, A N

“…Synovial T cells in rheumatoid arthritis are highly differentiated and express a phenotype suggesting susceptibility to apoptosis (CD45RB dull, CD45RO bright,…”
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Consistency and validity of patient administered assessment of quality of life by the MOS SF-36; its association with disease activity and damage in patients with systemic lupus erythematosus by Stoll, T, Gordon, C, Seifert, B, Richardson, K, Malik, J, Bacon, P A, Isenberg, D A

“…To investigate the metric properties and validity of the assessment of quality of life by the MOS Short Form 36 (SF-36) in patients with systemic lupus…”
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TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx by Church, Leigh D., Hessler, Gabriele, Goodall, John E., Rider, David A., Workman, Creg J., Vignali, Dario A. A., Bacon, Paul A., Gulbins, Erich, Young, Stephen P.

“…Tumor necrosis factor α (TNF‐α) is a potent, pleiotrophic cytokine, which is proinflammatory but can also suppress T lymphocyte function. In chronic…”
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Controlled trial of pulse versus continuous prednisolone and cyclophosphamide in the treatment of systemic vasculitis by ADU, D, PALL, A, LUQMANI, R. A, RICHARDS, N. T, HOWIE, A. J, EMERY, P, MICHAEL, J, SAVAGE, C. O. S, BACON, P. A

“…Although cyclophosphamide and prednisolone are effective in treating systemic vasculitis, the optimum treatment regimes and duration of treatment are unknown…”
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Treatment of antineutrophil cytoplasm autoantibody-associated systemic vasculitis: initiatives of the European Community Systemic Vasculitis Clinical Trials Study Group by Jayne, D R, Rasmussen, N

“…The diagnosis, treatment, and monitoring of the primary systemic vasculitides associated with circulating antineutrophil cytoplasm autoantibodies (ANCA) have…”
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Computerized information‐gathering in specialist rheumatology clinics: an initial evaluation of an electronic version of the Short Form 36 by Wilson, A. S., Kitas, G. D., Carruthers, D. M., Reay, C., Skan, J., Harris, S., Treharne, G. J., Young, S. P., Bacon, P. A.

“…Objectives. Longitudinal outcome data are important for research and are becoming part of routine clinical practice. We assessed an initial version of an…”
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Cardiac involvement in rheumatoid disease by Kitas, George, Banks, Matthew J, Bacon, Paul A

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The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis by Salmon, M, Pilling, D, Borthwick, N J, Viner, N, Janossy, G, Bacon, P A, Akbar, A N

“…Recent studies have suggested that T cell memory for recall antigens resides in clones of primed T cells with a short inter-mitotic half-life. In humans such…”
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Use of a corporate needs assessment to define the information requirements of an arthritis resource centre in Birmingham: comparison of patients’ and professionals’ views by Adab, P., Rankin, E. C. C., Witney, A. G., Miles, K. A., Bowman, S., Kitas, G. D., Situnayake, D., Bacon, P. A.

“…Objectives. Education and information are important components of the management of chronic disease, though provision of these in the routine clinic setting…”
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