Search Results - "Bacon, James A."

Prediction of renal transporter mediated drug-drug interactions for pemetrexed using physiologically based pharmacokinetic modeling by Posada, Maria M, Bacon, James A, Schneck, Karen B, Tirona, Rommel G, Kim, Richard B, Higgins, J William, Pak, Y Anne, Hall, Stephen D, Hillgren, Kathleen M

“…Pemetrexed, an anionic anticancer drug with a narrow therapeutic index, is eliminated mainly by active renal tubular secretion. The in vitro to in vivo…”
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Prediction of Transporter‐Mediated Drug‐Drug Interactions for Baricitinib by Posada, Maria M., Cannady, Ellen A., Payne, Christopher D., Zhang, Xin, Bacon, James A., Pak, Y. Anne, Higgins, J. William, Shahri, Nazila, Hall, Stephen D., Hillgren, Kathleen M.

“…Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, undergoes active renal tubular secretion. Baricitinib was not predicted to inhibit hepatic and…”
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Characterization of the Expression and Activity of Carboxylesterases 1 and 2 from the Beagle Dog, Cynomolgus Monkey, and Human by WILLIAMS, Eric T, BACON, James A, WRIGHTON, Steven A, PERKINS, Everett J, BENDER, David M, LOWINGER, Jennifer J, GUO, Wen-Kai, EHSANI, Mariam E, XILIANG WANG, HE WANG, QIAN, Yue-Wei, RUTERBORIES, Kenneth J

“…The carboxylesterases (CESs) are a family of serine hydrolases that hydrolyze compounds containing an ester, amide, or thioester. In humans, two dominant…”
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Breast Cancer Resistance Protein Interacts with Various Compounds in Vitro, but Plays a Minor Role in Substrate Efflux at the Blood-Brain Barrier by RONG ZHAO, RAUB, Thomas J, SAWADA, Geri A, KASPER, Steven C, BACON, James A, BRIDGES, Arlene S, POLLACK, Gary M

“…Expression of breast cancer resistance protein (Bcrp) at the blood-brain barrier (BBB) has been revealed recently. To investigate comprehensively the potential…”
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Metabolic, idiosyncratic toxicity of drugs: overview of the hepatic toxicity induced by the anxiolytic, panadiplon by Ulrich, Roger G, Bacon, James A, Brass, Eric P, Cramer, Clay T, Petrella, Diane K, Sun, Elena L

“…Preclinical drug safety evaluation studies, typically conducted in two or more animal species, reveal and define dose-dependent toxicities and undesirable…”
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Disruption of mitochondrial activities in rabbit and human hepatocytes by a quinoxalinone anxiolytic and its carboxylic acid metabolite by Ulrich, Roger G., Bacon, James A., Cramer, Clay T., Petrella, Diane K., Sun, Elena L., Meglasson, Martin D., Holmuhamedov, Ekhson

“…The quinoxalinone anxiolytic, panadiplon, was dropped from clinical development due to unexpected hepatic toxicity in human volunteers. Subsequent experimental…”
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Cultured hepatocytes as investigational models for hepatic toxicity: practical applications in drug discovery and development by Ulrich, Roger G., Bacon, James A., Cramer, Clay T., Peng, Geoffrey W., Petrella, Diane K., Stryd, Ronald P., Sun, Elena L.

“…Drugs can fail at any phase during discovery, preclinical or clinical development due to unacceptable levels of toxicity, and liver is commonly the principle…”
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Potentiation of hypoxic injury in cultured rabbit hepatocytes by the quinoxalinone anxiolytic, panadiplon by Bacon, James A., Cramer, Clay T., Petrella, Diane K., Sun, Elena L., Ulrich, Roger G.

“…The quinoxalinone anxiolytic, panadiplon, produces hepatic metabolic inhibition (mitochondrial impairment), microvesicular steatosis and centrilobular necrosis…”
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Induction of a hepatic toxic syndrome in the Dutch-belted rabbit by a quinoxalinone anxiolytic by Ulrich, Roger G., Bacon, James A., Branstetter, Daniel G., Cramer, Clay T., Funk, G.Michael, Hunt, Charles E., Petrella, Diane K., Sun, Elena L.

“…The non-benzodiazepine anxiolytic, panadiplon, was discontinued from clinical development due to evidence of hepatic toxicity in human volunteers that was not…”
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Two improved & inexpensive systems for moisture stabilization in seeds or other tissues 12 by Osborne, Thomas S., Bacon, James A.

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Radiosensitivity of Seeds: I. Reduction or Stimulation of Seedling Growth as a Function of Gamma-Ray Dose by Osborne, Thomas S., Bacon, James A.

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Two Improved & Inexpensive Systems for Moisture Stabilization in Seeds or Other Tissues by Osborne, Thomas S., Bacon, James A.

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Influence of excessive amounts of vit. D3 on strontium-89 metabolism in the rat by MRAZ, F R, BACON, J A

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Some effects of parathyroid extract and cortisone on metabolism of strontium and calcium by BACON, J A, HANSARD, S L, PATRICK, H

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