Search Results - "Bacon, J A"

SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study by Wider, C., Vilariño-Güell, C., Heckman, M. G., Jasinska-Myga, B., Ortolaza-Soto, A. I., Diehl, N. N., Crook, J. E., Cobb, S. A., Bacon, J. A., Aasly, J. O., Gibson, J. M., Lynch, T., Uitti, R. J., Wszolek, Z. K., Farrer, M. J., Ross, O. A.

“…Background and purpose:  Recent evidence suggests that variation in the SNCA, MAPT, and GSK3B genes interacts in affecting risk for Parkinson disease (PD). In…”
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The Use and Interpretation of Commercial APC Gene Testing for Familial Adenomatous Polyposis by Giardiello, Francis M, Brensinger, Jill D, Petersen, Gloria M, Luce, Michael C, Hylind, Linda M, Bacon, Judith A, Booker, Susan V, Parker, Rodger D, Hamilton, Stanley R

“…Over the past decade, numerous germ-line mutations have been discovered that increase the risk of inherited cancers. Clinical applications of these findings…”
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Phenotypic expression of disease in families that have Mutations in the 5' region of the adenomatous polyposis coli gene by GIARDIELLO, F. M, BRENSINGER, J. D, LUCE, M. C, PETERSEN, G. M, CAYOUETTE, M. C, KRUSH, A. J, BACON, J. A, BOOKER, S. V, BUFILL, J. A, HAMILTON, S. R

“…Germline mutation in a gene on chromosome 5 (the adenomatous polyposis coli gene) causes familial adenomatous polyposis of the colorectum. Phenotypic…”
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The effects of high and low energy density diets on satiety, energy intake, and eating time of obese and nonobese subjects by Duncan, KH, Bacon, JA, Weinsier, RL

“…The concept of time-energy displacement is based on the hypothesis that unrefined complex carbohydrates of low energy density will prolong eating time and…”
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Metabolic, idiosyncratic toxicity of drugs: overview of the hepatic toxicity induced by the anxiolytic, panadiplon by Ulrich, Roger G, Bacon, James A, Brass, Eric P, Cramer, Clay T, Petrella, Diane K, Sun, Elena L

“…Preclinical drug safety evaluation studies, typically conducted in two or more animal species, reveal and define dose-dependent toxicities and undesirable…”
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Disruption of mitochondrial activities in rabbit and human hepatocytes by a quinoxalinone anxiolytic and its carboxylic acid metabolite by Ulrich, Roger G., Bacon, James A., Cramer, Clay T., Petrella, Diane K., Sun, Elena L., Meglasson, Martin D., Holmuhamedov, Ekhson

“…The quinoxalinone anxiolytic, panadiplon, was dropped from clinical development due to unexpected hepatic toxicity in human volunteers. Subsequent experimental…”
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Cultured hepatocytes as investigational models for hepatic toxicity: practical applications in drug discovery and development by Ulrich, Roger G., Bacon, James A., Cramer, Clay T., Peng, Geoffrey W., Petrella, Diane K., Stryd, Ronald P., Sun, Elena L.

“…Drugs can fail at any phase during discovery, preclinical or clinical development due to unacceptable levels of toxicity, and liver is commonly the principle…”
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Iodine in milk and meat of dairy cows fed different amounts of potassium iodide or ethylenediamine dihydroiodide by Swanson, E W, Miller, J K, Mueller, F J, Patton, C S, Bacon, J A, Ramsey, N

“…Relationships between I intake by lactating Holstein cows and iodine concentrations in milk and meat were investigated. Six treatment groups with seven cows…”
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Attitudes toward Colon Cancer Gene Testing: Factors Predicting Test Uptake by Codori, A M, Petersen, G M, Miglioretti, D L, Larkin, E K, Bushey, M T, Young, C, Brensinger, J D, Johnson, K, Bacon, J A, Booker, S V

“…Objectives. Genetic discoveries in hereditary nonpolyposis colorectal cancer (HNPCC) have made possible genetic testing to determine susceptibility to this…”
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Evidence against genetic anticipation in familial colorectal cancer by Tsai, Ya-Yu, Petersen, Gloria M., Booker, Susan V., Bacon, Judith A., Hamilton, Stanley R., Giardiello, Francis M.

“…Anecdotal reports of hereditary colorectal cancer suggest that genetic anticipation (earlier appearance in successive generations) occurs, but ascertainment…”
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Potentiation of hypoxic injury in cultured rabbit hepatocytes by the quinoxalinone anxiolytic, panadiplon by Bacon, James A., Cramer, Clay T., Petrella, Diane K., Sun, Elena L., Ulrich, Roger G.

“…The quinoxalinone anxiolytic, panadiplon, produces hepatic metabolic inhibition (mitochondrial impairment), microvesicular steatosis and centrilobular necrosis…”
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Induction of a hepatic toxic syndrome in the Dutch-belted rabbit by a quinoxalinone anxiolytic by Ulrich, Roger G., Bacon, James A., Branstetter, Daniel G., Cramer, Clay T., Funk, G.Michael, Hunt, Charles E., Petrella, Diane K., Sun, Elena L.

“…The non-benzodiazepine anxiolytic, panadiplon, was discontinued from clinical development due to evidence of hepatic toxicity in human volunteers that was not…”
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EOS: a demonstrator of hybrid optical detector technology by Anderson, T, Anderssen, E, Askins, M, Bacon, A. J, Bagdasarian, Z, Baldoni, A, Barros, N, Bartoszek, L, Bergevin, M, Bernstein, A, Blucher, E, Boissevain, J, Bonventre, R, Brown, D, Callaghan, E. J, Cowen, D. F, Dazeley, S, Diwan, M, Duce, M, Fleming, D, Frankiewicz, K, Gooding, D. M, Grant, C, Juechter, J, Kaptanoglu, T, Kim, T, Klein, J. R, Kraus, C, Kroupová, T, Land, B, Lebanowski, L, Lozza, V, Marino, A, Mastbaum, A, Mauger, C, Mayers, G, Minock, J, Naugle, S, Newcomer, M, Nikolica, A, Gann, G. D. Orebi, Pickard, L, Ren, L, Rincon, A, Rowe, N, Saba, J, Schoppmann, S, Sensenig, J, Smiley, M, Song, H, Steiger, H, Svoboda, R, Tiras, E, To, W. H, Trzaska, W. H, Van Berg, R, Veeraraghavan, V, Wallig, J, Wendel, G, Wetstein, M, Wurm, M, Yang, G, Yeh, M, Zimmerman, E. D

“…EOS is a technology demonstrator, designed to explore the capabilities of hybrid event detection technology, leveraging both Cherenkov and scintillation light…”
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Comparative in vitro effects of closantel and selected β-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells by BACON, J.A., ULRICH, R.G., DAVIS, J.P., THOMAS, E.M., JOHNSON, S.S., CONDER, G.A., SANGSTER, N.C., ROTHWELL, J.T., MCCRACKEN, R.O., LEE, B.H., CLOTHIER, M.F., GEARY, T.G., THOMPSON, D.P.

“…PNU‐87407 and PNU‐88509, β‐ketoamide anthelmintics that are structurally related to each other and to the salicylanilide anthelmintic closantel, exhibit…”
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Effect of magnesium administration route on plasma minerals in Holstein calves receiving either adequate or insufficient magnesium in their diets by Bacon, J A, Bell, M C, Miller, J K, Ramsey, N, Mueller, F J

“…Rates of increase in plasma Mg following rectal or oral administration of solutions containing 30 g MgCl2.6H2O were compared in 10 Holstein bull calves…”
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The identification of spiroacetals in the volatile secretions of two species of fruit fly (Dacus dorsalis, Dacus curcurbitae) by Baker, R., Bacon, A. J.

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Photoelectron spectroscopy of Rydberg states of the methyl radical by Bacon, J.A, Pratt, S.T

“…Photoelectron spectra following two-photon resonant, three-photon ionization of CH 3 and CD 3 via selected vibronic levels of the 3p z and 4p z Rydberg states…”
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Time-calorie displacement diet for weight control: a prospective evaluation of its adequacy for maintaining normal nutritional status by Weinsier, R L, Bacon, J A, Birch, R

“…An unsupplemented 1000 kcal (4186 kJ) diet emphasizing large quantities of unrefined complex carbohydrates was evaluated for nutritional adequacy in a 20-week…”
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Effects of supplemental selenium on swine. I. Gestation and lactation by Wilkinson, J.E, Bell, M.C, Bacon, J.A, Masincupp, F.B

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Radioiodine absorption and secretion by the calf abomasum by Miller, J K, Chandler, P T, Cragle, R G, Bacon, J A, Wykoff, M H

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