Search Results - "Backx, P H"

Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles by So, P P‐S, Backx, P H, Dorian, P

“…Background and purpose: The slow delayed rectifier K+ current (IKs) contributes to ventricular repolarization when the action potential (AP) is prolonged. IKs…”
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Effects of development and thyroid hormone on K+ currents and K+ channel gene expression in rat ventricle by Wickenden, A. D., Kaprielian, R., Parker, T. G., Jones, O. T., Backx, P. H.

“…1. In rat heart, three K+ channel genes that encode inactivating transient outward (ITO)-like currents are expressed. During development the predominant K+…”
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Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle by Wickenden, A D, Jegla, T J, Kaprielian, R, Backx, P H

“…The aim of the present study was to assess differences in transient outward potassium current (Ito) between the right ventricular free wall and the…”
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Impaired Glucose-Stimulated Insulin Secretion, Enhanced Intraperitoneal Insulin Tolerance, and Increased β-Cell Mass in Mice Lacking the p110γ Isoform of Phosphoinositide 3-Kinase by MacDonald, P. E, Joseph, J. W, Yau, D, Diao, J, Asghar, Z, Dai, F, Oudit, G. Y, Patel, M. M, Backx, P. H, Wheeler, M. B

“…Phosphoinositide 3-kinase (PI3 kinase) has been implicated in G protein-coupled receptor regulation of pancreatic β-cell growth and glucose-stimulated insulin…”
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Modulation of Iron Uptake in Heart by L-Type Ca2+ Channel Modifiers: Possible Implications in Iron Overload by Tsushima, Robert G, Wickenden, Alan D, Bouchard, Ron A, Oudit, Gavin Y, Liu, Peter P, Backx, Peter H

“…Heart failure is the leading cause of mortality in patients with transfusional iron (Fe) overload in which myocardial iron uptake ensues via a…”
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Relationship between intracellular calcium and contractile force in stunned myocardium : direct evidence for decreased myofilament Ca2+ responsiveness and altered diastolic function in intact ventricular muscle by WEI DONG GAO, ATAR, D, BACKX, P. H, MARBAN, E

“…To elucidate the abnormalities of excitation-contraction coupling in stunned myocardium, we measured [Ca2+]i and force in thin fura 2-loaded ventricular…”
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Fluorescent properties of rat cardiac trabeculae microinjected with fura-2 salt by Backx, P H, Ter Keurs, H E

“…We have measured force, sarcomere length, and Ca2+ during twitches in rat cardiac trabeculae. To avoid the difficulties associated with fura-2/acetoxymethyl…”
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Myofilament Ca2+ Sensitivity in Intact Versus Skinned Rat Ventricular Muscle by Gao, Wei Dong, Backx, Peter H, Azan-Backx, Michelle, Marban, Eduardo

“…The Ca sensitivity of myofilaments was compared before and after skinning in the same rat trabeculae at a diastolic sarcomere length of 2.2 to 2.3 μm…”
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Rate-dependent changes of twitch force duration in rat cardiac trabeculae: a property of the contractile system by Kassiri, Z., Myers, R., Kaprielian, R., Banijamali, H. S., Backx, P. H.

“…We examined the mechanisms for rate-dependent changes in twitch force duration by simultaneously measuring force and [Ca 2+ ] i in rat cardiac trabeculae. Peak…”
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Mechanism of force inhibition by 2,3-butanedione monoxime in rat cardiac muscle: roles of [Ca2+]i and cross-bridge kinetics by Backx, P H, Gao, W D, Azan‐Backx, M D, Marban, E

“…1. We investigated the mechanism of force inhibition by 2,3-butanedione monoxime (BDM) on rat cardiac trabeculae. [Ca2+]i was measured by iontophoretic…”
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Altered K(+) channel gene expression in diabetic rat ventricle: isoform switching between Kv4.2 and Kv1.4 by Nishiyama, A, Ishii, D N, Backx, P H, Pulford, B E, Birks, B R, Tamkun, M M

“…Expression of voltage-gated K(+) channels encoding the K(+) independent transient outward current in the streptozocin-induced diabetic (DM) rat ventricle was…”
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Molecular Localization of an Ion-Binding Site within the Pore of Mammalian Sodium Channels by Backx, Peter H., Yue, David T., Lawrence, John H., Marban, Eduardo, Tomaselli, Gordon F.

“…Sodium channels are the major proteins that underlie excitability in nerve, heart, and skeletal muscle. Chemical reaction rate theory was used to analyze the…”
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Background Potassium Current Active During the Plateau of the Action Potential in Guinea Pig Ventricular Myocytes by Backx, Peter H, Marban, Eduardo

“…Background outward K currents in guinea pig ventricular myocytes were characterized over a broad range of membrane potentials, including those corresponding to…”
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The relationship between contractile force and intracellular [Ca2+] in intact rat cardiac trabeculae by Backx, P H, Gao, W D, Azan-Backx, M D, Marban, E

“…The control of force by [Ca2+] was investigated in rat cardiac trabeculae loaded with fura-2 salt. At sarcomere lengths of 2.1-2.3 microns, the steady state…”
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Chloride Channel Inhibition Blocks the Protection of Ischemic Preconditioning and Hypo-Osmotic Stress in Rabbit Ventricular Myocardium by Diaz, Roberto J, Losito, Vito A, Mao, Gou D, Ford, Meredith K, Backx, Peter H, Wilson, Gregory J

“…The objective of this study was to examine the role of chloride (Cl ()) channels in the myocardial protection of ischemic preconditioning (IP). Isolated rabbit…”
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Phosphorylation-Independent Modulation of L-Type Calcium Channels by Magnesium-Nucleotide Complexes by O'Rourke, Brian, Backx, Peter H., Marban, Eduardo

“…Free magnesium ions and magnesium-nucleotide complexes can exert opposite effects on many fundamental cellular processes. Although increases in the…”
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Cardiac function and cytotoxic aldehyde production in a murine model of chronic iron-overload by BARTFAY, W. J, DAWOOD, F, WEN, W. H, LEHOTAY, D. C, HOU, D, BARTFAY, E, XIAOPING LUO, BACKX, P. H, LIU, P. P

“…To determine the relationship between the total chronic dose of iron administered, ex-vivo cardiac function and the concentrations of cytotoxic aldehydes in…”
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Calcium-Sensitive Inactivation in the Gating of Single Calcium Channels by Yue, David T., Backx, Peter H., Imredy, John P.

“…Voltage-activated calcium channels open and close, or gate, according to molecular transition rates that are regulated by transmembrane voltage and…”
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Inactivated state dependence of sodium channel modulation by beta-scorpion toxin by Tsushima, R G, Borges, A, Backx, P H

“…We have examined the effects of a beta-scorpion toxin purified from the venom of the Venezuelan scorpion Tityus discrepans, TdVIII, on heterologously expressed…”
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The equine periodic paralysis Na+ channel mutation alters molecular transitions between the open and inactivated states by Hanna, W J, Tsushima, R G, Sah, R, McCutcheon, L J, Marban, E, Backx, P H

“…1. The Na+ channel mutation associated with equine hyperkalaemic periodic paralysis (HPP) affects a highly conserved phenylalanine residue in an unexplored…”
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