Search Results - "Backs, J."

CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy by Backs, Johannes, Song, Kunhua, Bezprozvannaya, Svetlana, Chang, Shurong, Olson, Eric N

“…Class IIa histone deacetylases (HDACs) regulate a variety of cellular processes, including cardiac growth, bone development, and specification of skeletal…”
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New Insights in RBM20 Cardiomyopathy by Lennermann, D., Backs, J., van den Hoogenhof, M. M. G.

“…Purpose of Review This review aims to give an update on recent findings related to the cardiac splicing factor RNA-binding motif protein 20 (RBM20) and RBM20…”
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Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease by Siede, D., Rapti, K., Gorska, A.A., Katus, H.A., Altmüller, J., Boeckel, J.N., Meder, B., Maack, C., Völkers, M., Müller, O.J., Backs, J., Dieterich, C.

“…Cardiovascular disease, one of the most common causes of death in western populations, is characterized by changes in RNA splicing and expression. Circular…”
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Warning systems triggered by trains increase flight-initiation times of wildlife by Backs, Jonathan A.J., Nychka, John A., St. Clair, Colleen Cassady

“…•Precisely timed warning signals might help wildlife to avoid approaching trains.•Animal flight initiation in response to trains was measured with and without…”
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Warning systems triggered by trains could reduce collisions with wildlife by Backs, J.A.J., Nychka, J.A., St. Clair, C.C.

“…[Display omitted] •Trains sometimes strike animals that fail to detect trains early enough.•Strike risk might be reduced if animals were warned of approaching…”
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Ectopic expression of S28A-mutated Histone H3 modulates longevity, stress resistance and cardiac function in Drosophila by Joos, J. P., Saadatmand, A. R., Schnabel, C., Viktorinová, I., Brand, T., Kramer, M., Nattel, S., Dobrev, D., Tomancak, P., Backs, J., Kleinbongard, P., Heusch, G., Lorenz, K., Koch, E., Weber, S., El-Armouche, A.

“…Histone H3 serine 28 (H3S28) phosphorylation and de-repression of polycomb repressive complex (PRC)-mediated gene regulation is linked to stress conditions in…”
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A nanoplasmonic probe for near-field imaging by Backs, J A J, Sederberg, S, Elezzabi, A Y

“…We demonstrate a nanoplasmonic probe that incorporates a subwavelength aperture coupled to a fine probing tip. This probe is used in a hybrid near-field…”
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Macrovascular disease in diabetes: is the mouse a suitable model? by Müller, O J, Katus, H A, Backs, J

“…To elucidate the pathogenesis of macrovascular disease in diabetes, animal models are widely used. Diabetic mice are of particular interest because they can be…”
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Endothelin-1 inhibits the neuronal norepinephrine transporter in hearts of male rats by BACKS, Johannes, BRESCH, Elke, LUTZ, Matthias, KRISTEN, Arnt V, HAASS, Markus

“…Endothelin-1 (ET-1) potentiates norepinephrine (NE)-induced contractile responses. An impairment of cardiac NE re-uptake by the neuronal NE transporter (NET)…”
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Control of Cardiac Growth by Histone Acetylation/Deacetylation by Backs, Johannes, Olson, Eric N

“…Histones control gene expression by modulating the structure of chromatin and the accessibility of regulatory DNA sequences to transcriptional activators and…”
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RBM20 Mutations Induce an Arrhythmogenic Dilated Cardiomyopathy Related to Disturbed Calcium Handling by van den Hoogenhof, Maarten M.G, Beqqali, Abdelaziz, Amin, Ahmad S, van der Made, Ingeborg, Aufiero, Simona, Khan, Mohsin A.F, Schumacher, Cees A, Jansweijer, Joeri A, van Spaendonck-Zwarts, Karin Y, Remme, Carol Ann, Backs, Johannes, Verkerk, Arie O, Baartscheer, Antonius, Pinto, Yigal M, Creemers, Esther E

“…BACKGROUND:Mutations in RBM20 (RNA-binding motif protein 20) cause a clinically aggressive form of dilated cardiomyopathy, with an increased risk of malignant…”
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Characterization of atrial cardiomyopathy subtypes - A cellular electrophysiological comparison and evaluation of appropriate treatment options by Weirauch, L, Grosch, M, Wiedmann, F, Sicklinger, F, Tiemann, T, Van Den Hoogenhof, M, Brauer, J, Konrad, P, Paasche, A, Leuschner, F, Lehmann, L, Backs, J, Steinmetz, L, Frey, N, Schmidt, C

“…Abstract Background Atrial fibrillation occurs in the context of atrial remodeling processes which are the result of an underlying atrial cardiomyopathy (AC)…”
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Pathophysiology of Takotsubo syndrome – a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology – Part 1: overview and the central role for catecholamines and sympathetic nervous system by Omerovic, Elmir, Citro, Rodolfo, Bossone, Eduardo, Redfors, Bjorn, Backs, Johannes, Bruns, Bastian, Ciccarelli, Michele, Couch, Liam S., Dawson, Dana, Grassi, Guido, Iacoviello, Massimo, Parodi, Guido, Schneider, Birke, Templin, Christian, Ghadri, Jelena R., Thum, Thomas, Chioncel, Ovidiu, Tocchetti, C. Gabriele, Velden, Jolanda, Heymans, Stephane, Lyon, Alexander R.

“…This is the first part of a scientific statement from the Heart Failure Association (HFA) of the European Society of Cardiology focused upon the…”
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Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC) by Boer, Rudolf A., Heymans, Stephane, Backs, Johannes, Carrier, Lucie, Coats, Andrew J.S., Dimmeler, Stefanie, Eschenhagen, Thomas, Filippatos, Gerasimos, Gepstein, Lior, Hulot, Jean‐Sebastien, Knöll, Ralph, Kupatt, Christian, Linke, Wolfgang A., Seidman, Christine E., Tocchetti, C. Gabriele, Velden, Jolanda, Walsh, Roddy, Seferovic, Petar M., Thum, Thomas

“…Genetic cardiomyopathies are disorders of the cardiac muscle, most often explained by pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion…”
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Atrial disease and heart failure: the common soil hypothesis proposed by the Heart Failure Association of the European Society of Cardiology by Coats, Andrew J S, Heymans, Stephane, Farmakis, Dimitrios, Anker, Stefan D, Backs, Johannes, Bauersachs, Johann, de Boer, Rudolf A, Čelutkienė, Jelena, Cleland, John G F, Dobrev, Dobromir, van Gelder, Isabelle C, von Haehling, Stephan, Hindricks, Gerhard, Jankowska, Ewa, Kotecha, Dipak, van Laake, Linda W, Lainscak, Mitja, Lund, Lars H, Lunde, Ida Gjervold, Lyon, Alexander R, Manouras, Aristomenis, Miličić, Davor, Mueller, Christian, Polovina, Marija, Ponikowski, Piotr, Rosano, Giuseppe, Seferović, Petar M, Tschöpe, Carsten, Wachter, Rolf, Ruschitzka, Frank

“…Graphical Abstract Graphical Abstract A proposed conceptual framework for understanding atrial disease. Subclinical atrial disease develops under the effect of…”
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The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation by Gatsiou, Aikaterini, Tual-Chalot, Simon, Napoli, Matteo, Ortega-Gomez, Almudena, Regen, Tommy, Badolia, Rachit, Cesarini, Valeriana, Garcia-Gonzalez, Claudia, Chevre, Raphael, Ciliberti, Giorgia, Silvestre-Roig, Carlos, Martini, Maurizio, Hoffmann, Jedrzej, Hamouche, Rana, Visker, Joseph R., Diakos, Nikolaos, Wietelmann, Astrid, Silvestris, Domenico Alessandro, Georgiopoulos, Georgios, Moshfegh, Ali, Schneider, Andre, Chen, Wei, Guenther, Stefan, Backs, Johannes, Kwak, Shin, Selzman, Craig H., Stamatelopoulos, Kimon, Rose-John, Stefan, Trautwein, Christian, Spyridopoulos, Ioakim, Braun, Thomas, Waisman, Ari, Gallo, Angela, Drakos, Stavros G., Dimmeler, Stefanie, Sperandio, Markus, Soehnlein, Oliver, Stellos, Konstantinos

“…Immune cell trafficking constitutes a fundamental component of immunological response to tissue injury, but the contribution of intrinsic RNA nucleotide…”
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4924DNA methylation regulates cardiac alternative splicing in DCM by Gi, W T, Haas, J, Lai, A, Sedaghat-Hamedani, F, Kayvanpour, E, Amr, A, Frese, K, Backs, J, Keller, A, Posch, A, Katus, H, Meder, B

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Heart Failure Association of the European Society of Cardiology Quality of Care Centres Programme: design and accreditation document by Seferović, Petar M., Piepoli, Massimo F., Lopatin, Yuri, Jankowska, Ewa, Polovina, Marija, Anguita‐Sanchez, Manuel, Störk, Stefan, Lainščak, Mitja, Miličić, Davor, Milinković, Ivan, Filippatos, Gerasimos, Coats, Andrew J.S.

“…Heart failure (HF) is the major contributor to cardiovascular morbidity and mortality. Given its rising prevalence, the costs of HF care can be expected to…”
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The challenges of research data management in cardiovascular science: a DGK and DZHK position paper—executive summary by Steffens, Sabine, Schröder, Katrin, Krüger, Martina, Maack, Christoph, Streckfuss-Bömeke, Katrin, Backs, Johannes, Backofen, Rolf, Baeßler, Bettina, Devaux, Yvan, Gilsbach, Ralf, Heijman, Jordi, Knaus, Jochen, Kramann, Rafael, Linz, Dominik, Lister, Allyson L., Maatz, Henrike, Maegdefessel, Lars, Mayr, Manuel, Meder, Benjamin, Nussbeck, Sara Y., Rog-Zielinska, Eva A., Schulz, Marcel H., Sickmann, Albert, Yigit, Gökhan, Kohl, Peter

“…The sharing and documentation of cardiovascular research data are essential for efficient use and reuse of data, thereby aiding scientific transparency,…”
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P3760Comprehensive fingerprints of plasma, heart, liver, and muscle tissue disclose systemic metabolic alterations in cardiac hypertrophy and heart failure by Mueller, O J, Heckmann, M H, Ding, L, Rapti, K, Rangrez, A Y, Rennefahrt, U E E, Ruf, T, Jungmann, A, Weis, T, Kreusser, J, Backs, J, Frey, N, Katus, H A

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