Search Results - "Backman, Vadim"

Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients by Daneshkhah, Ali, Agrawal, Vasundhara, Eshein, Adam, Subramanian, Hariharan, Roy, Hemant Kumar, Backman, Vadim

“…Objectives We present evidence for a possible role of Vitamin D (VitD) deficiency in unregulated cytokine production and inflammation leading to complications…”
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Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins by Stephens, Andrew D, Liu, Patrick Z, Banigan, Edward J, Almassalha, Luay M, Backman, Vadim, Adam, Stephen A, Goldman, Robert D, Marko, John F

“…Nuclear shape and architecture influence gene localization, mechanotransduction, transcription, and cell function. Abnormal nuclear morphology and protrusions…”
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Visible-light optical coherence tomography for retinal oximetry by Yi, Ji, Wei, Qing, Liu, Wenzhong, Backman, Vadim, Zhang, Hao F

“…We applied a visible-light spectroscopic optical coherence tomography (vis-OCT) for in vivo retinal oximetry. To extract hemoglobin oxygen saturation (sO(2))…”
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Photonic nanojet enhancement of backscattering of light by nanoparticles: a potential novel visible-light ultramicroscopy technique by Chen, Zhigang, Taflove, Allen, Backman, Vadim

“…We report what we believe to be the first evidence of localized nanoscale photonic jets generated at the shadow-side surfaces of micronscale, circular…”
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Macromolecular Crowding as a Regulator of Gene Transcription by Matsuda, Hiroaki, Putzel, Gregory Garbès, Backman, Vadim, Szleifer, Igal

“…Studies of macromolecular crowding have shown its important effects on molecular transport and interactions in living cells. Less clear is the effect of…”
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Super-resolution spectroscopic microscopy via photon localization by Dong, Biqin, Almassalha, Luay, Urban, Ben E., Nguyen, The-Quyen, Khuon, Satya, Chew, Teng-Leong, Backman, Vadim, Sun, Cheng, Zhang, Hao F.

“…Traditional photon localization microscopy analyses only the spatial distributions of photons emitted by individual molecules to reconstruct super-resolution…”
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Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation by Stephens, Andrew D, Liu, Patrick Z, Kandula, Viswajit, Chen, Haimei, Almassalha, Luay M, Herman, Cameron, Backman, Vadim, O'Halloran, Thomas, Adam, Stephen A, Goldman, Robert D, Banigan, Edward J, Marko, John F

“…The nucleus houses, organizes, and protects chromatin to ensure genome integrity and proper gene expression, but how the nucleus adapts mechanically to changes…”
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Early screening of colorectal cancer using feature engineering with artificial intelligence-enhanced analysis of nanoscale chromatin modifications by Chang, Andrew, Prabhala, Sravya, Daneshkhah, Ali, Lin, Jianan, Subramanian, Hariharan, Roy, Hemant Kumar, Backman, Vadim

“…Colonoscopy is accurate but inefficient for colorectal cancer (CRC) prevention due to the low (~ 7 to 8%) prevalence of target lesions, advanced adenomas. We…”
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Local volume concentration, packing domains, and scaling properties of chromatin by Carignano, Marcelo A, Kroeger, Martin, Almassalha, Luay M, Agrawal, Vasundhara, Li, Wing Shun, Pujadas-Liwag, Emily M, Nap, Rikkert J, Backman, Vadim, Szleifer, Igal

“…We propose the Self Returning Excluded Volume (SR-EV) model for the structure of chromatin based on stochastic rules and physical interactions. The SR-EV…”
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In vivo capture and label-free detection of early metastatic cells by Azarin, Samira M., Yi, Ji, Gower, Robert M., Aguado, Brian A., Sullivan, Megan E., Goodman, Ashley G., Jiang, Eric J., Rao, Shreyas S., Ren, Yinying, Tucker, Susan L., Backman, Vadim, Jeruss, Jacqueline S., Shea, Lonnie D

“…Breast cancer is a leading cause of death for women, with mortality resulting from metastasis. Metastases are often detected once tumour cells affect the…”
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Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization by Kant, Aayush, Guo, Zixian, Vinayak, Vinayak, Neguembor, Maria Victoria, Li, Wing Shun, Agrawal, Vasundhara, Pujadas, Emily, Almassalha, Luay, Backman, Vadim, Lakadamyali, Melike, Cosma, Maria Pia, Shenoy, Vivek B.

“…In interphase nuclei, chromatin forms dense domains of characteristic sizes, but the influence of transcription and histone modifications on domain size is not…”
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Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation by Yi, Ji, Liu, Wenzhong, Chen, Siyu, Backman, Vadim, Sheibani, Nader, Sorenson, Christine M., Fawzi, Amani A., Linsenmeier, Robert A., Zhang, Hao F.

“…The lack of capability to quantify oxygen metabolism noninvasively impedes both fundamental investigation and clinical diagnosis of a wide spectrum of diseases…”
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Analysis of three-dimensional chromatin packing domains by chromatin scanning transmission electron microscopy (ChromSTEM) by Li, Yue, Agrawal, Vasundhara, Virk, Ranya K. A., Roth, Eric, Li, Wing Shun, Eshein, Adam, Frederick, Jane, Huang, Kai, Almassalha, Luay, Bleher, Reiner, Carignano, Marcelo A., Szleifer, Igal, Dravid, Vinayak P., Backman, Vadim

“…Chromatin organization over multiple length scales plays a critical role in the regulation of transcription. Deciphering the interplay of these processes…”
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HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure by Stypula-Cyrus, Yolanda, Damania, Dhwanil, Kunte, Dhananjay P, Cruz, Mart Dela, Subramanian, Hariharan, Roy, Hemant K, Backman, Vadim

“…Normal cell function is dependent on the proper maintenance of chromatin structure. Regulation of chromatin structure is controlled by histone modifications…”
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Crowding-induced structural alterations of random-loop chromosome model by Kim, Jun Soo, Backman, Vadim, Szleifer, Igal

“…We investigate structural alterations of random-loop polymers due to changes in the crowding condition, as a model to study environmental effects on the…”
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Optical analysis of nanoparticles via enhanced backscattering facilitated by 3-D photonic nanojets by Li, Xu, Chen, Zhigang, Taflove, Allen, Backman, Vadim

“…We report the phenomenon of ultra-enhanced backscattering of visible light by nanoparticles facilitated by the 3-D photonic nanojet - a sub-diffraction light…”
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Multimodal interference-based imaging of nanoscale structure and macromolecular motion uncovers UV induced cellular paroxysm by Gladstein, Scott, Almassalha, Luay M., Cherkezyan, Lusik, Chandler, John E., Eshein, Adam, Eid, Aya, Zhang, Di, Wu, Wenli, Bauer, Greta M., Stephens, Andrew D., Morochnik, Simona, Subramanian, Hariharan, Marko, John F., Ameer, Guillermo A., Szleifer, Igal, Backman, Vadim

“…Understanding the relationship between intracellular motion and macromolecular structure remains a challenge in biology. Macromolecular structures are…”
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Photonic nanojet-enabled optical data storage by Kong, Soon-Cheol, Sahakian, Alan, Taflove, Allen, Backman, Vadim

“…We show that our recently reported microwave photonic jet technique for detection of deeply subwavelength pits in a metal substrate can be extended to optical…”
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Two electric field Monte Carlo models of coherent backscattering of polarized light by Doronin, Alexander, Radosevich, Andrew J, Backman, Vadim, Meglinski, Igor

“…Modeling of coherent polarized light propagation in turbid scattering medium by the Monte Carlo method provides an ultimate understanding of coherent effects…”
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Early detection of lung cancer using artificial intelligence-enhanced optical nanosensing of chromatin alterations in field carcinogenesis by Daneshkhah, Ali, Prabhala, Sravya, Viswanathan, Parvathi, Subramanian, Hariharan, Lin, Jianan, Chang, Andrew S, Bharat, Ankit, Roy, Hemant Kumar, Backman, Vadim

“…Supranucleosomal chromatin structure, including chromatin domain conformation, is involved in the regulation of gene expression and its dysregulation has been…”
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