Search Results - "Backes, Walter H."

Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease by Wong, Sau May, Jansen, Jacobus F.A, Zhang, C Eleana, Hoff, Erik I, Staals, Julie, van Oostenbrugge, Robert J, Backes, Walter H

“…OBJECTIVETo investigate the link between blood-brain-barrier (BBB) permeability and cerebral blood flow (CBF) and the relation with white matter…”
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Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations by Thrippleton, Michael J., Backes, Walter H., Sourbron, Steven, Ingrisch, Michael, van Osch, Matthias J.P., Dichgans, Martin, Fazekas, Franz, Ropele, Stefan, Frayne, Richard, van Oostenbrugge, Robert J., Smith, Eric E., Wardlaw, Joanna M.

“…Cerebral small vessel disease (cSVD) comprises pathological processes of the small vessels in the brain that may manifest clinically as stroke, cognitive…”
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Quality control strategies for brain MRI segmentation and parcellation: Practical approaches and recommendations - insights from the Maastricht study by Monereo-Sánchez, Jennifer, de Jong, Joost J.A., Drenthen, Gerhard S., Beran, Magdalena, Backes, Walter H., Stehouwer, Coen D.A., Schram, Miranda T., Linden, David E.J., Jansen, Jacobus F.A.

“…Quality control of brain segmentation is a fundamental step to ensure data quality. Manual quality control strategies are the current gold standard, although…”
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Blood-Brain Barrier Leakage and Microvascular Lesions in Cerebral Amyloid Angiopathy by Freeze, Whitney M, Bacskai, Brian J, Frosch, Matthew P, Jacobs, Heidi I.L, Backes, Walter H, Greenberg, Steven M, van Veluw, Susanne J

“…BACKGROUND AND PURPOSE—Cerebral amyloid angiopathy (CAA) is a common small vessel disease that independently effects cognition in older individuals. The…”
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Comparing the efficacy of data-driven denoising methods for a multi-echo fMRI acquisition at 7T by Beckers, Abraham B., Drenthen, Gerhard S., Jansen, Jacobus F.A., Backes, Walter H., Poser, Benedikt A., Keszthelyi, Daniel

“…•ME-ICA and ICA-AROMA provide effective denoising for multi-echo 7T fMRI data.•High tSNR can be achieved in the brainstem with a multi-echo acquisition at…”
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White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed by Freeze, Whitney M., Jacobs, Heidi I.L., de Jong, Joost J., Verheggen, Inge C.M., Gronenschild, Ed H.B.M., Palm, Walter M., Hoff, Erik I., Wardlaw, Joanna M., Jansen, Jacobus F.A., Verhey, Frans R., Backes, Walter H.

“…Blood-brain barrier (BBB) leakage is considered an important underlying process in both cerebral small vessel disease (cSVD) and Alzheimer's disease (AD). The…”
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Estimating myelin-water content from anatomical and diffusion images using spatially undersampled myelin-water imaging through machine learning by Drenthen, Gerhard S., Backes, Walter H., Jansen, Jacobus F.A.

“…Myelin is vital for healthy neuronal development, and can therefore provide valuable information regarding neuronal maturation. Anatomical and diffusion…”
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Linking human cerebral and ocular waste clearance: Insights from tear fluid and ultra-high field MRI by van der Thiel, Merel M., van de Sande, Nienke, Meeusen, Anouk, Drenthen, Gerhard S., Postma, Alida A., Nuijts, Rudy M.M.A., van der Knaap, Noa, Ramakers, Inez H.G.B., Webers, Carroll A.B., Backes, Walter H., Gijs, Marlies, Jansen, Jacobus F.A.

“…Impaired cerebral waste clearance (i.e., glymphatics) is evident in aging and neurodegenerative disorders, such as Alzheimer's disease, where an impaired waste…”
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Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease by Wong, Sau May, Backes, Walter H., Drenthen, Gerhard S., Zhang, C. Eleana, Voorter, Paulien H.M., Staals, Julie, Oostenbrugge, Robert J., Jansen, Jacobus F.A.

“…Background Cerebral intravoxel incoherent motion (IVIM) imaging assumes two components. However, more compartments are likely present in pathologic tissue. We…”
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Subtle blood‐brain barrier leakage rate and spatial extent: Considerations for dynamic contrast‐enhanced MRI by Haar, Harm J., Jansen, Jacobus F.A., Jeukens, Cécile R.L.P.N., Burgmans, Saartje, Buchem, Mark A., Muller, Majon, Hofman, Paul A.M., Verhey, Frans R.J., Osch, Matthias J.P., Backes, Walter H.

“…Purpose Dynamic contrast‐enhanced (DCE) MRI can be used to measure blood‐brain barrier (BBB) leakage. In neurodegenerative disorders such as small vessel…”
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Blood–brain barrier leakage in relation to white matter hyperintensity volume and cognition in small vessel disease and normal aging by Zhang, C. Eleana, Wong, Sau May, Uiterwijk, Renske, Backes, Walter H., Jansen, Jacobus F. A., Jeukens, Cécile R. L. P. N., van Oostenbrugge, Robert J., Staals, Julie

“…Blood–brain barrier (BBB) leakage increases with age and is involved in the pathophysiology of cerebral small vessel disease (cSVD). We examined the…”
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Increase in blood–brain barrier leakage in healthy, older adults by Verheggen, Inge C. M., de Jong, Joost J. A., van Boxtel, Martin P. J., Gronenschild, Ed H. B. M., Palm, Walter M., Postma, Alida A., Jansen, Jacobus F. A., Verhey, Frans R. J., Backes, Walter H.

“…Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which affects neuronal functioning. Currently, dynamic contrast-enhanced…”
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Functional and structural network impairment in childhood frontal lobe epilepsy by Vaessen, Maarten J, Jansen, Jacobus F A, Braakman, Hilde M H, Hofman, Paul A M, De Louw, Anton, Aldenkamp, Albert P, Backes, Walter H

“…In childhood frontal lobe epilepsy (FLE), cognitive impairment and educational underachievement are serious, well-known co-morbidities. The broad scale of…”
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Structural and resting state functional connectivity of the subthalamic nucleus: identification of motor STN parts and the hyperdirect pathway by Brunenberg, Ellen J L, Moeskops, Pim, Backes, Walter H, Pollo, Claudio, Cammoun, Leila, Vilanova, Anna, Janssen, Marcus L F, Visser-Vandewalle, Veerle E R M, ter Haar Romeny, Bart M, Thiran, Jean-Philippe, Platel, Bram

“…Deep brain stimulation (DBS) for Parkinson's disease often alleviates the motor symptoms, but causes cognitive and emotional side effects in a substantial…”
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Glutamate quantification by PRESS or MEGA-PRESS: Validation, repeatability, and concordance by van Veenendaal, Tamar M., Backes, Walter H., van Bussel, Frank C.G., Edden, Richard A.E., Puts, Nicolaas A.J., Aldenkamp, Albert P., Jansen, Jacobus F.A.

“…While PRESS is often employed to measure glutamate concentrations, MEGA-PRESS enables simultaneous Glx (glutamate and glutamine) and GABA measurements. This…”
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Hypoxic oligodendrocyte precursor cell-derived VEGFA is associated with blood-brain barrier impairment by Manukjan, Narek, Majcher, Daria, Leenders, Peter, Caiment, Florian, van Herwijnen, Marcel, Smeets, Hubert J, Suidgeest, Ernst, van der Weerd, Louise, Vanmierlo, Tim, Jansen, Jacobus F A, Backes, Walter H, van Oostenbrugge, Robert J, Staals, Julie, Fulton, Daniel, Ahmed, Zubair, Blankesteijn, W Matthijs, Foulquier, Sébastien

“…Cerebral small vessel disease is characterised by decreased cerebral blood flow and blood-brain barrier impairments which play a key role in the development of…”
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Circulating N-Acetylaspartate does not track brain NAA concentrations, cognitive function or features of small vessel disease in humans by Rebelos, Eleni, Daniele, Giuseppe, Campi, Beatrice, Saba, Alessandro, Koskensalo, Kalle, Ihalainen, Jukka, Saukko, Ekaterina, Nuutila, Pirjo, Backes, Walter H., Jansen, Jacobus F. A., Dagnelie, Pieter C., Köhler, Sebastian, de Galan, Bastiaan E., van Sloten, Thomas T., Stehouwer, Coen D. A., Ferrannini, Ele

“…N-acetylaspartate (NAA) is the second most abundant metabolite in the human brain; although it is assumed to be a proxy for a neuronal marker, its function is…”
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Blood-brain barrier impairment in dementia: current and future in vivo assessments by van de Haar, Harm J, Burgmans, Saartje, Hofman, Paul A M, Verhey, Frans R J, Jansen, Jacobus F A, Backes, Walter H

“…Increasing evidence indicates that blood-brain barrier (BBB) impairment may play a role in the pathophysiology of cognitive decline and dementia. In vivo…”
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Efficacy of Radiation Safety Glasses in Interventional Radiology by van Rooijen, Bart D., de Haan, Michiel W., Das, Marco, Arnoldussen, Carsten W. K. P., de Graaf, R., van Zwam, Wim H., Backes, Walter H., Jeukens, Cécile R. L. P. N.

“…Purpose This study was designed to evaluate the reduction of the eye lens dose when wearing protective eyewear in interventional radiology and to identify…”
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Functional brain network characteristics are associated with epilepsy severity in childhood absence epilepsy by Drenthen, Gerhard S., Fasen, Floor, Fonseca Wald, Eric L.A., Backes, Walter H., Aldenkamp, Albert P., Vermeulen, R. Jeroen, Debeij-van Hall, Mariette, Hendriksen, Jos, Klinkenberg, Sylvia, Jansen, Jacobus F.A.

“…•The functional network of children with childhood absence epilepsy is less efficiently organized in terms of clustering and small-worldness.•Longer path…”
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