Search Results - "Back, Catherine"

Derivation of a Precise and Consistent Timeline for Antibiotic Development by Stennett, Henry L, Back, Catherine R, Race, Paul R

“…Antibiotic resistance is a global health crisis. New classes of antibiotics that can treat drug-resistant infections are urgently needed. To communicate this…”
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The Streptococcus gordonii Adhesin CshA Protein Binds Host Fibronectin via a Catch-Clamp Mechanism by Back, Catherine R., Sztukowska, Maryta N., Till, Marisa, Lamont, Richard J., Jenkinson, Howard F., Nobbs, Angela H., Race, Paul R.

“…Adherence of bacteria to biotic or abiotic surfaces is a prerequisite for host colonization and represents an important step in microbial pathogenicity. This…”
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Domain shuffling of a highly mutable ligand‐binding fold drives adhesin generation across the bacterial kingdom by Barringer, Rob, Parnell, Alice E., Lafita, Aleix, Monzon, Vivian, Back, Catherine R., Madej, Mariusz, Potempa, Jan, Nobbs, Angela H., Burston, Steven G., Bateman, Alex, Race, Paul R.

“…Bacterial fibrillar adhesins are specialized extracellular polypeptides that promote the attachment of bacteria to the surfaces of other cells or materials…”
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Antibiotic origami: selective formation of spirotetronates in abyssomicin biosynthesis by Mbatha, Sbusisiwe Z, Back, Catherine R, Devine, Andrew J, Mulliner, Hannah M, Johns, Samuel T, Lewin, Harry, Cheung, Kaiman A, Zorn, Katja, Stach, James E M, Hayes, Martin A, van der Kamp, Marc W, Race, Paul R, Willis, Christine L

“…The abyssomicins are a structurally intriguing family of bioactive natural products that include compounds with potent antibacterial, antitumour and antiviral…”
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The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis by Devine, Andrew J., Parnell, Alice E., Back, Catherine R., Lees, Nicholas R., Johns, Samuel T., Zulkepli, Ainul Z., Barringer, Rob, Zorn, Katja, Stach, James E. M., Crump, Matthew P., Hayes, Martin A., Kamp, Marc W., Race, Paul R., Willis, Christine L.

“…Abyssomicin C and its atropisomer are potent inhibitors of bacterial folate metabolism. They possess complex polycyclic structures, and their biosynthesis has…”
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A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge by Back, Catherine R, Stennett, Henry L, Williams, Sam E, Wang, Luoyi, Ojeda Gomez, Jorge, Abdulle, Omar M, Duffy, Thomas, Neal, Christopher, Mantell, Judith, Jepson, Mark A, Hendry, Katharine R, Powell, David, Stach, James E M, Essex-Lopresti, Angela E, Willis, Christine L, Curnow, Paul, Race, Paul R

“…To tackle the growing problem of antibiotic resistance, it is essential to identify new bioactive compounds that are effective against resistant microbes and…”
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Interrogation of an Enzyme Library Reveals the Catalytic Plasticity of Naturally Evolved [4+2] Cyclases by Zorn, Katja, Back, Catherine R., Barringer, Rob, Chadimová, Veronika, Manzo‐Ruiz, Monserrat, Mbatha, Sbusisiwe Z., Mobarec, Juan‐Carlos, Williams, Sam E., Kamp, Marc W., Race, Paul R., Willis, Christine L., Hayes, Martin A.

“…Stereoselective carbon‐carbon bond forming reactions are quintessential transformations in organic synthesis. One example is the Diels‐Alder reaction, a [4+2]…”
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Delineation of the complete reaction cycle of a natural Diels-Alderase by Maschio, Laurence, Back, Catherine R, Alnawah, Jawaher, Bowen, James I, Johns, Samuel T, Mbatha, Sbusisiwe Z, Han, Li-Chen, Lees, Nicholas R, Zorn, Katja, Stach, James E M, Hayes, Martin A, van der Kamp, Marc W, Pudney, Christopher R, Burston, Steven G, Willis, Christine L, Race, Paul R

“…The Diels-Alder reaction is one of the most effective methods for the synthesis of substituted cyclohexenes. The development of protein catalysts for this…”
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The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture by Back, Catherine R., Higman, Victoria A., Le Vay, Kristian, Patel, Viren V., Parnell, Alice E., Frankel, Daniel, Jenkinson, Howard F., Burston, Steven G., Crump, Matthew P., Nobbs, Angela H., Race, Paul R.

“…The cell surfaces of many bacteria carry filamentous polypeptides termed adhesins that enable binding to both biotic and abiotic surfaces. Surface adherence is…”
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Correction: Back et al. A New Micromonospora Strain with Antibiotic Activity Isolated from the Microbiome of a Mid-Atlantic Deep-Sea Sponge. Mar. Drugs 2021, 19 , 105 by Back, Catherine R, Stennett, Henry L, Williams, Sam E, Wang, Luoyi, Ojeda Gomez, Jorge, Abdulle, Omar M, Duffy, Thomas, Neal, Christopher, Mantell, Judith, Jepson, Mark A, Hendry, Katharine R, Powell, David, Stach, James E M, Essex-Lopresti, Angela E, Willis, Christine L, Curnow, Paul, Race, Paul R

“…After publication of this article [...]…”
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Staphylococcal Complement Evasion Protein Sbi Stabilises C3d Dimers by Inducing an N-Terminal Helix Swap by Dunphy, Rhys W, Wahid, Ayla A, Back, Catherine R, Martin, Rebecca L, Watts, Andrew G, Dodson, Charlotte A, Crennell, Susan J, van den Elsen, Jean M H

“…is an opportunistic pathogen that is able to thwart an effective host immune response by producing a range of immune evasion molecules, including binder of IgG…”
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Designer artificial membrane binding proteins to direct stem cells to the myocardium by Xiao, Wenjin, Green, Thomas I. P, Liang, Xiaowen, Delint, Rosalia Cuahtecontzi, Perry, Guillaume, Roberts, Michael S, Le Vay, Kristian, Back, Catherine R, Ascione, Raimomdo, Wang, Haolu, Race, Paul R, Perriman, Adam W

“…We present a new cell membrane modification methodology where the inherent heart tissue homing properties of the infectious bacteria Streptococcus gordonii are…”
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Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation by Nair, Asha V., Robson, Alice, Ackrill, Thomas D., Till, Marisa, Byrne, Matthew J., Back, Catherine R., Tiwari, Kavita, Davies, Jonathan A., Willis, Christine L., Race, Paul R.

“…Complex polyketides of bacterial origin are biosynthesised by giant assembly-line like megaenzymes of the type 1 modular polyketide synthase (PKS) class. The…”
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Discovery and biosynthetic assessment of ' Streptomyces ortus' sp. nov. isolated from a deep-sea sponge by Williams, Sam E, Back, Catherine R, Best, Eleanor, Mantell, Judith, Stach, James E M, Williams, Tom A, Race, Paul R, Curnow, Paul

“…The deep sea is known to host novel bacteria with the potential to produce a diverse array of undiscovered natural products. Thus, understanding these bacteria…”
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Utilization of Staphylococcal Immune Evasion Protein Sbi as a Novel Vaccine Adjuvant by Yang, Yi, Back, Catherine R, Gräwert, Melissa A, Wahid, Ayla A, Denton, Harriet, Kildani, Rebecca, Paulin, Joshua, Wörner, Kristin, Kaiser, Wolgang, Svergun, Dmitri I, Sartbaeva, Asel, Watts, Andrew G, Marchbank, Kevin J, van den Elsen, Jean M H

“…Co-ligation of the B cell antigen receptor with complement receptor 2 on B-cells via a C3d-opsonised antigen complex significantly lowers the threshold…”
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Concerted functions of Streptococcus gordonii surface proteins PadA and Hsa mediate activation of human platelets and interactions with extracellular matrix by Haworth, Jennifer A., Jenkinson, Howard F., Petersen, Helen J., Back, Catherine R., Brittan, Jane L., Kerrigan, Steve W., Nobbs, Angela H.

“…Summary A range of Streptococcus bacteria are able to interact with blood platelets to form a thrombus (clot). Streptococcus gordonii is ubiquitous within the…”
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Insights Into the Structure-Function Relationships of Dimeric C3d Fragments by Wahid, Ayla A, Dunphy, Rhys W, Macpherson, Alex, Gibson, Beth G, Kulik, Liudmila, Whale, Kevin, Back, Catherine, Hallam, Thomas M, Alkhawaja, Bayan, Martin, Rebecca L, Meschede, Ingrid, Laabei, Maisem, Lawson, Alastair D G, Holers, V Michael, Watts, Andrew G, Crennell, Susan J, Harris, Claire L, Marchbank, Kevin J, van den Elsen, Jean M H

“…Cleavage of C3 to C3a and C3b plays a central role in the generation of complement-mediated defences. Although the thioester-mediated surface deposition of C3b…”
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The Bristol Sponge Microbiome Collection: A Unique Repository of Deep-Sea Microorganisms and Associated Natural Products by Williams, Sam E, Stennett, Henry L, Back, Catherine R, Tiwari, Kavita, Ojeda Gomez, Jorge, Challand, Martin R, Hendry, Katharine R, Spencer, James, Essex-Lopresti, Angela E, Willis, Christine L, Curnow, Paul, Race, Paul R

“…The deep ocean is the largest habitat for life on Earth, though the microorganisms that occupy this unique environmental niche remain largely unexplored. Due…”
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The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis by Devine, Andrew J., Parnell, Alice E., Back, Catherine R., Lees, Nicholas R., Johns, Samuel T., Zulkepli, Ainul Z., Barringer, Rob, Zorn, Katja, Stach, James E. M., Crump, Matthew P., Hayes, Martin A., Kamp, Marc W., Race, Paul R., Willis, Christine L.

“…Abyssomicin C and its atropisomer are potent inhibitors of bacterial folate metabolism. They possess complex polycyclic structures, and their biosynthesis has…”
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Structural and Functional Studies of the Streptococcal Fibrillar Adhesin CshA by Back, Catherine, Higman‐Davies, Victoria, Sztukowska, Maryta, Till, Marisa, Crump, Matthew, Lamont, Richard, Jenkinson, Howard, Nobbs, Angela, Race, Paul

“…Adherence of bacteria to biotic or abiotic surfaces is a prerequisite for host colonization and represents an important step in microbial pathogenicity. This…”
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