Search Results - "Bachus, Holly"

Integrated STAT3 and Ikaros Zinc Finger Transcription Factor Activities Regulate Bcl-6 Expression in CD4 + Th Cells by Read, Kaitlin A, Powell, Michael D, Baker, Chandra E, Sreekumar, Bharath K, Ringel-Scaia, Veronica M, Bachus, Holly, Martin, R Emily, Cooley, Ian D, Allen, Irving C, Ballesteros-Tato, Andre, Oestreich, Kenneth J

“…B cell lymphoma-6 (Bcl-6) is a transcriptional repressor that is required for the differentiation of T follicular helper (T ) cell populations. Currently, the…”
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Immunotargeting of T Follicular Helper (TFH) Cells for SLE Treatment by Papillion, Amber M, Bachus, Holly, Ballesteros-Tato, Andre

“…Abstract T follicular helper (TFH) cells promote antibody (Ab) responses by providing both survival and differentiation signals to B cells. As such, the…”
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Cutting Edge: Low-dose Recombinant IL-2 Treatment Prevents Autoantibody Responses in Systemic Lupus Erythematosus via Regulatory T Cell-independent Depletion of T Follicular Helper Cells by Santana, Silvia, Papillion, Amber, Foote, Jeremy B, Bachus, Holly, León, Beatriz, De Miguel, Carmen, Ballesteros-Tato, André

“…The expansion of T follicular helper (Tfh) cells correlates with disease progression in human and murine systemic lupus erythematosus (SLE). Unfortunately,…”
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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection by Botta, Davide, Fuller, Michael J, Marquez-Lago, Tatiana T, Bachus, Holly, Bradley, John E, Weinmann, Amy S, Zajac, Allan J, Randall, Troy D, Lund, Frances E, León, Beatriz, Ballesteros-Tato, André

“…Humoral immunity is necessary for controlling viral infection. Ballesteros-Tato and colleagues show that development of follicular regulatory T cells is…”
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Priming of Long-Lived Memory CD8+ T cell Responses in the Spleen During Influenza Virus Infection by Jenkins, Meagan M, Bachus, Holly, Botta, Davide, Schultz, Michael, Rosenberg, Alexander, León, Beatriz, Ballesteros-Tato, André

“…Abstract CD8+ T cell responses to influenza virus infection are canonically known to be activated solely in the lung draining, mediastinal lymph node (mLN)…”
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A temporal switch in T follicular helper cells controls the output of the GC response to influenza by Arroyo, Nicole M, Bachus, Holly, Papillion, Amber, Rosenberg, Alexander F., Bradley, John Edwin, Leon-Ruiz, Beatriz, Ballesteros-Tato, Andre

“…Abstract T follicular helper (Tfh) cells are a specific subset of CD4 T cells that localize in the B cell follicle and are essential for the Germinal Center…”
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Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants by Bachus, Holly, Kaur, Kamaljeet, Papillion, Amber M., Marquez-Lago, Tatiana T., Yu, Zhihong, Ballesteros-Tato, André, Matalon, Sadis, León, Beatriz

“…Infants have a higher risk of developing allergic asthma than adults. However, the underlying mechanism remains unknown. We show here that sensitization of…”
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Interferon-γ production by Tfh cells is required for CXCR3+ pre-memory B cell differentiation and subsequent lung-resident memory B cell responses by Arroyo-Díaz, Nicole M., Bachus, Holly, Papillion, Amber, Randall, Troy D., Akther, Jobaida, Rosenberg, Alexander F., León, Beatriz, Ballesteros-Tato, André

“…Lung-resident memory B cells (lung-BRMs) differentiate into plasma cells after reinfection, providing enhanced pulmonary protection. Here, we investigated the…”
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Priming by lung-mDCs in the spleen initiates CD8+ T cell responses during influenza infection by Jenkins, Meagan M, Bachus, Holly, Botta, Davide, Leon-Ruiz, Beatriz, Ballesteros-Tato, Andre

“…Abstract Initiation of CD8+ T cell responses to influenza virus requires the trafficking of activated lung-migratory dendritic cells (mDCs) from the lung into…”
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GM-CSF production by non-classical monocytes controls antagonistic LPS-driven functions in allergic inflammation by Kaur, Kamaljeet, Bachus, Holly, Lewis, Crystal, Papillion, Amber M., Rosenberg, Alexander F., Ballesteros-Tato, André, León, Beatriz

“…Lipopolysaccharide (LPS) can either promote or prevent T helper 2 (Th2) cell allergic responses. However, the underlying mechanism remains unknown. We show…”
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Lung-migratory Dendritic Cells traffic into the spleen after influenza virus infection by Jenkins, Meagan M, Bachus, Holly, Leon-Ruiz, Beatriz, Ballesteros-Tato, Andre

“…Abstract Initiation of CD8+ T cell responses to influenza virus requires the trafficking of lung-migratory dendritic cells (mDCs) from the lung into the…”
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IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling by Bachus, Holly, McLaughlin, Erin, Lewis, Crystal, Papillion, Amber M., Benveniste, Etty N., Hill, Dave Durell, Rosenberg, Alexander F., Ballesteros-Tato, André, León, Beatriz

“…Defective interleukin-6 (IL-6) signaling has been associated with Th2 bias and elevated IgE levels. However, the underlying mechanism by which IL-6 prevents…”
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Trafficking of lung-migratory cDC2s into the spleen following influenza virus infection by Jenkins, Meagan M., Bachus, Holly, Leon-Ruiz, Beatriz, Ballesteros-Tato, Andre

“…Abstract Trafficking of antigen-bearing, migratory conventional dendritic cells type 1 (cDC1) and type 2 (cDC2) from the lung into the lung-draining…”
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IL-6 counteracts IL-2-dependent suppression of T follicular helper cell responses by Papillion, Amber M., Bachus, Holly, Fuller, Michael, León, Beatriz, Ballesteros-Tato, Andre

“…Abstract T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells that aide in the production of high-affinity antibody (Ab) responses. In the…”
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Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-T FH cells by Papillion, Amber, Powell, Michael D, Chisolm, Danielle A, Bachus, Holly, Fuller, Michael J, Weinmann, Amy S, Villarino, Alejandro, O'Shea, John J, León, Beatriz, Oestreich, Kenneth J, Ballesteros-Tato, André

“…Sustained T cell receptor (TCR) stimulation is required for maintaining germinal center T follicular helper (GC-T ) cells. Paradoxically, TCR activation…”
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Duration of antigen presentation to influenza-specific CD8+ T cells regulates the development of tissue resident memory populations by Fuller, Michael John, Botta, Davide, Schultz, Michael D., Bachus, Holly, Ballesteros-Tato, Andre

“…Abstract Some memory CD8+ T cells are programmed during the contraction phase of the primary response to have robust secondary responsiveness, a phenomenon…”
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Impaired tumor-necrosis-factor-α-driven dendritic cell activation limits lipopolysaccharide-induced protection from allergic inflammation in infants by Kaur, Kamaljeet, Bachus, Holly, Papillion, Amber M., Marquez-Lago, Tatiana T., Yu, Zhihong, Ballesteros-Tato, Andre, Matalon, Sadis, Leon-Ruiz, Beatriz

“…Abstract Infants have a higher risk of developing allergic asthma than adults. However, the underlying mechanism remains unknown. We show here that…”
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Local and long-range transcriptional regulation of the Bcl6 locus by Ikaros zinc finger factors by Powell, Michael Duane, Read, Kaitlin A., Sreekumar, Bharath, Carrillo, Gabriela L., Ringel-Scaia, Veronica, Bachus, Holly, Allen, Irving C., Ballesteros-Tato, Andre, Oestreich, Kenneth J.

“…Abstract T follicular helper (TFH) cells play a pivotal role in the humoral immune response by providing help to B cells, resulting in germinal center…”
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Dynamic regulation of T Follicular Regulatory (Tfr) cell responses by Interleukin-2 (IL-2) during influenza infection by Ballesteros-Tato, Andre, Botta, Davide, Fuller, Michael J, Bachus, Holly, Bradley, John E, Zajac, Allan J, Randall, Troy D, Lund, Frances E, Ruiz, Beatriz León

“…Abstract IL-2 promotes FoxP3+ regulatory T (Treg) cell responses, but inhibits the differentiation of T follicular helper (Tfh) cells. However, it is not clear…”
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Integrated STAT3 and Ikaros Zinc Finger transcription factor activities regulate Bcl-6 expression in CD4+ T helper cells by Read, Kaitlin A., Powell, Michael D., Baker, Chandra E., Sreekumar, Bharath K., Ringel-Scaia, Veronica M., Bachus, Holly, Martin, R. Emily, Cooley, Ian D., Allen, Irving C., Ballesteros-Tato, Andre, Oestreich, Kenneth J.

“…Bcl-6 (B cell lymphoma-6) is a transcriptional repressor required for the differentiation of T follicular helper (T FH ) cell populations. Currently, the…”
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