Search Results - "Bachert, Collin"

Functional dissection of the retrograde Shiga toxin trafficking inhibitor Retro-2 by Forrester, Alison, Rathjen, Stefan J., Daniela Garcia-Castillo, Maria, Bachert, Collin, Couhert, Audrey, Tepshi, Livia, Pichard, Sylvain, Martinez, Jennifer, Munier, Mathilde, Sierocki, Raphael, Renard, Henri-François, Augusto Valades-Cruz, César, Dingli, Florent, Loew, Damarys, Lamaze, Christophe, Cintrat, Jean-Christophe, Linstedt, Adam D., Gillet, Daniel, Barbier, Julien, Johannes, Ludger

“…The retrograde transport inhibitor Retro-2 has a protective effect on cells and in mice against Shiga-like toxins and ricin. Retro-2 causes toxin accumulation…”
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Dual Anchoring of the GRASP Membrane Tether Promotes trans Pairing by Bachert, Collin, Linstedt, Adam D.

“…GRASP proteins share an N-terminal GRASP domain and mediate homotypic tethering of Golgi cisternae to form extended Golgi ribbons. The golgin GM130 is thought…”
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Endosomal Trafficking and Proprotein Convertase Cleavage of cis Golgi Protein GP73 Produces Marker for Hepatocellular Carcinoma by Bachert, Collin, Fimmel, Claus, Linstedt, Adam D

“…Serum GP73 levels are significantly increased in patients with hepatocellular carcinoma (HCC), potentially providing a marker for early detection. However,…”
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A Sensor of Protein O‐Glycosylation Based on Sequential Processing in the Golgi Apparatus by Bachert, Collin, Linstedt, Adam D.

“…Protein O‐glycosylation is important in numerous processes including the regulation of proteolytic processing sites by O‐glycan masking in select newly…”
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Organelle tethering by a homotypic PDZ interaction underlies formation of the Golgi membrane network by Sengupta, Debrup, Truschel, Steven, Bachert, Collin, Linstedt, Adam D

“…Formation of the ribbon-like membrane network of the Golgi apparatus depends on GM130 and GRASP65, but the mechanism is unknown. We developed an in vivo…”
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Allosteric Regulation of GRASP Protein-dependent Golgi Membrane Tethering by Mitotic Phosphorylation by Truschel, Steven T., Zhang, Ming, Bachert, Collin, Macbeth, Mark R., Linstedt, Adam D.

“…Mitotic phosphorylation of the conserved GRASP domain of GRASP65 disrupts its self-association, leading to a loss of Golgi membrane tethering, cisternal…”
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Development of Isoform-specific Sensors of Polypeptide GalNAc-transferase Activity by Song, Lina, 宋, 丽娜, Bachert, Collin, Schjoldager, Katrine T., Clausen, Henrik, Linstedt, Adam D.

“…Humans express up to 20 isoforms of GalNAc-transferase (herein T1–T20) that localize to the Golgi apparatus and initiate O-glycosylation. Regulation of this…”
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Cycling of Early Golgi Proteins Via the Cell Surface and Endosomes Upon Lumenal pH Disruption by Puri, Sapna, Bachert, Collin, Fimmel, Claus J., Linstedt, Adam D.

“…The cis‐Golgi protein GPP130 reversibly redistributes to endosomes upon pH disruption, but the identity of the endosomes and the involved cycling route are…”
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Selective Enrichment of Cell Surface Proteins Using ProMTag to Detect O‐glycosylation‐Dependent Changes by Minden, Jonathan S., Bachert, Collin, Linstedt, Adam, Lucas, Amber

“…O‐linked glycosylation, which is regulated by the enzyme GalNAc transferase, plays a vital role in cellular function by regulating membrane protein composition…”
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Induced oligomerization targets Golgi proteins for degradation in lysosomes by Tewari, Ritika, Bachert, Collin, Linstedt, Adam D

“…Manganese protects cells against forms of Shiga toxin by down-regulating the cycling Golgi protein GPP130. Down-regulation occurs when Mn binding causes GPP130…”
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Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines by Hintze, John, Ye, Zilu, Narimatsu, Yoshiki, Madsen, Thomas Daugbjerg, Joshi, Hiren J., Goth, Christoffer K., Linstedt, Adam, Bachert, Collin, Mandel, Ulla, Bennett, Eric P., Vakhrushev, Sergey Y., Schjoldager, Katrine T.

“…The GalNAc-type O-glycoproteome is orchestrated by a large family of polypeptide GalNAc-transferase isoenzymes (GalNAc-Ts) with partially overlapping…”
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Myristoylation Restricts Orientation of the GRASP Domain on Membranes and Promotes Membrane Tethering by Heinrich, Frank, Nanda, Hirsh, Goh, Haw Zan, Bachert, Collin, Lösche, Mathias, Linstedt, Adam D.

“…The mammalian Golgi reassembly stacking protein (GRASP) proteins are Golgi-localized homotypic membrane tethers that organize Golgi stacks into a long,…”
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Manganese-induced trafficking and turnover of the cis-Golgi glycoprotein GPP130 by Mukhopadhyay, Somshuvra, Bachert, Collin, Smith, Donald R, Linstedt, Adam D

“…Manganese is an essential element that is also neurotoxic at elevated exposure. However, mechanisms regulating Mn homeostasis in mammalian cells are largely…”
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GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution by Linstedt, Adam D, Puthenveedu, Manojkumar A, Bachert, Collin, Puri, Sapna, Lanni, Frederick

“…The mammalian Golgi apparatus exists as stacks of cisternae that are laterally linked to form a continuous membrane ribbon, but neither the molecular…”
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Activity Detection of GalNAc Transferases by Protein-Based Fluorescence Sensors In Vivo by Song, Lina, Bachert, Collin, Linstedt, Adam D

“…Mucin-type O-glycosylation occurring in the Golgi apparatus is an important protein posttranslational modification initiated by up to 20 GalNAc-transferase…”
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Myristoylation Restricts Orientation of GRASP on Membranes and is Critical for Membrane Tethering by Heinrich, Frank, Nanda, Hirsh, Goh, Haw Zan, Bachert, Collin, Linstedt, Adam D., Lösche, Mathias

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Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein by Bachert, C, Lee, T H, Linstedt, A D

“…Despite the potential importance of retrieval-based targeting, few Golgi cisternae-localized proteins have been demonstrated to be targeted by retrieval, and…”
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