Search Results - "Bachem, Annabell"

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection by Doerflinger, Marcel, Deng, Yexuan, Whitney, Paul, Salvamoser, Ranja, Engel, Sven, Kueh, Andrew J., Tai, Lin, Bachem, Annabell, Gressier, Elise, Geoghegan, Niall D., Wilcox, Stephen, Rogers, Kelly L., Garnham, Alexandra L., Dengler, Michael A., Bader, Stefanie M., Ebert, Gregor, Pearson, Jaclyn S., De Nardo, Dominic, Wang, Nancy, Yang, Chenying, Pereira, Milton, Bryant, Clare E., Strugnell, Richard A., Vince, James E., Pellegrini, Marc, Strasser, Andreas, Bedoui, Sammy, Herold, Marco J.

“…Programmed cell death contributes to host defense against pathogens. To investigate the relative importance of pyroptosis, necroptosis, and apoptosis during…”
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Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells by Bachem, Annabell, Güttler, Steffen, Hartung, Evelyn, Ebstein, Frédéric, Schaefer, Michael, Tannert, Astrid, Salama, Abdulgabar, Movassaghi, Kamran, Opitz, Corinna, Mages, Hans W, Henn, Volker, Kloetzel, Peter-Michael, Gurka, Stephanie, Kroczek, Richard A

“…In recent years, human dendritic cells (DCs) could be subdivided into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the…”
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Caspase-2 does not play a critical role in cell death induction and bacterial clearance during Salmonella infection by Engel, Sven, Doerflinger, Marcel, Lee, Ariane R., Strasser, Andreas, Herold, Marco J., Bedoui, Sammy, Bachem, Annabell

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GPR41 and GPR43 regulate CD8 + T cell priming during herpes simplex virus type 1 infection by Lee, Ariane Renita, Wilson, Kayla Roberta, Clarke, Michele, Engel, Sven, Tscharke, David C, Gebhardt, Thomas, Bedoui, Sammy, Bachem, Annabell

“…Naïve CD8 T cells need to undergo a complex and coordinated differentiation program to gain the capacity to control virus infections. This not only involves…”
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Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen by Brown, Andrew S, Yang, Chao, Fung, Ka Yee, Bachem, Annabell, Bourges, Dorothée, Bedoui, Sammy, Hartland, Elizabeth L, van Driel, Ian R

“…Legionella pneumophila is the causative agent of Legionnaires' disease, a potentially fatal lung infection. Alveolar macrophages support intracellular…”
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Nuclear response to divergent mitochondrial DNA genotypes modulates the interferon immune response by Lopez Sanchez, M. Isabel G, Ziemann, Mark, Bachem, Annabell, Makam, Rahul, Crowston, Jonathan G, Pinkert, Carl A, McKenzie, Matthew, Bedoui, Sammy, Trounce, Ian A, Bai, Yidong, Shukla, Deepak

“…Mitochondrial OXPHOS generates most of the energy required for cellular function. OXPHOS biogenesis requires the coordinated expression of the nuclear and…”
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T Cell Help Amplifies Innate Signals in CD8+ DCs for Optimal CD8+ T Cell Priming by Greyer, Marie, Whitney, Paul G., Stock, Angus T., Davey, Gayle M., Tebartz, Christina, Bachem, Annabell, Mintern, Justine D., Strugnell, Richard A., Turner, Stephen J., Gebhardt, Thomas, O’Keeffe, Meredith, Heath, William R., Bedoui, Sammy

“…DCs often require stimulation from CD4+ T cells to propagate CD8+ T cell responses, but precisely how T cell help optimizes the priming capacity of DCs and why…”
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Expression of XCR1 Characterizes the Batf3-Dependent Lineage of Dendritic Cells Capable of Antigen Cross-Presentation by Bachem, Annabell, Hartung, Evelyn, Güttler, Steffen, Mora, Ahmed, Zhou, Xuefei, Hegemann, Anika, Plantinga, Maud, Mazzini, Elisa, Stoitzner, Patrizia, Gurka, Stephanie, Henn, Volker, Mages, Hans W, Kroczek, Richard A

“…Cross-presentation of antigen by dendritic cells (DCs) to CD8(+) T cells is a fundamentally important mechanism in the defense against pathogens and tumors…”
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TLR2-mediated activation of innate responses in the upper airways confers antiviral protection of the lungs by Deliyannis, Georgia, Wong, Chinn Yi, McQuilten, Hayley A, Bachem, Annabell, Clarke, Michele, Jia, Xiaoxiao, Horrocks, Kylie, Zeng, Weiguang, Girkin, Jason, Scott, Nichollas E, Londrigan, Sarah L, Reading, Patrick C, Bartlett, Nathan W, Kedzierska, Katherine, Brown, Lorena E, Mercuri, Francesca, Demaison, Christophe, Jackson, David C, Chua, Brendon Y

“…The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections pose an equal and ongoing risk…”
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Ontogenic, Phenotypic, and Functional Characterization of XCR1+ Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPΠby Becker, Martina, Güttler, Steffen, Bachem, Annabell, Hartung, Evelyn, Mora, Ahmed, Jäkel, Anika, Hutloff, Andreas, Henn, Volker, Mages, Hans Werner, Gurka, Stephanie, Kroczek, Richard A.

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Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells by Bachem, Annabell, Makhlouf, Christina, Binger, Katrina J., de Souza, David P., Tull, Deidra, Hochheiser, Katharina, Whitney, Paul G., Fernandez-Ruiz, Daniel, Dähling, Sabrina, Kastenmüller, Wolfgang, Jönsson, Johanna, Gressier, Elise, Lew, Andrew M., Perdomo, Carolina, Kupz, Andreas, Figgett, William, Mackay, Fabienne, Oleshansky, Moshe, Russ, Brendan E., Parish, Ian A., Kallies, Axel, McConville, Malcolm J., Turner, Stephen J., Gebhardt, Thomas, Bedoui, Sammy

“…Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and function. Here, we examined the…”
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Functional flexibility and plasticity in immune control of systemic Salmonella infection by Engel, Sven, Bachem, Annabell, Strugnell, Richard A, Strasser, Andreas, Herold, Marco J, Bedoui, Sammy

“…Immunity to systemic Salmonella infection depends on multiple effector mechanisms. Lymphocyte-derived interferon gamma (IFN-γ) enhances cell-intrinsic…”
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Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches by Dähling, Sabrina, Mansilla, Ana Maria, Knöpper, Konrad, Grafen, Anika, Utzschneider, Daniel T., Ugur, Milas, Whitney, Paul G., Bachem, Annabell, Arampatzi, Panagiota, Imdahl, Fabian, Kaisho, Tsuneyasu, Zehn, Dietmar, Klauschen, Frederick, Garbi, Natalio, Kallies, Axel, Saliba, Antoine-Emmanuel, Gasteiger, Georg, Bedoui, Sammy, Kastenmüller, Wolfgang

“…Reinvigoration of exhausted CD8+ T (Tex) cells by checkpoint immunotherapy depends on the activation of precursors of exhausted T (Tpex) cells, but the local…”
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Induction of potent CD8 T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1 by Hartung, Evelyn, Becker, Martina, Bachem, Annabell, Reeg, Nele, Jäkel, Anika, Hutloff, Andreas, Weber, Harald, Weise, Christoph, Giesecke, Claudia, Henn, Volker, Gurka, Stephanie, Anastassiadis, Konstantinos, Mages, Hans W, Kroczek, Richard A

“…Current subunit vaccines are incapable of inducing Ag-specific CD8(+) T cell cytotoxicity needed for the defense of certain infections and for therapy of…”
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Microbiota-derived butyrate promotes cellular metabolism and memory potential of antigen-activated CD8+ T cells by Bedoui, Sammy, Binger, Katrina, Kallies, Axel, Turner, Stephen John, McConville, Malcolm, Gebhardt, Thomas, Bachem, Annabell

“…Abstract Microbiota modulate the immune system and recent studies suggest a functional relationship between microbiota, its metabolites and CD8+ T cells, but…”
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Posttranslational Modification as a Critical Determinant of Cytoplasmic Innate Immune Recognition by Baker, Paul J, De Nardo, Dominic, Moghaddas, Fiona, Tran, Le Son, Bachem, Annabell, Nguyen, Tan, Hayman, Thomas, Tye, Hazel, Vince, James E, Bedoui, Sammy, Ferrero, Richard L, Masters, Seth L

“…Cell surface innate immune receptors can directly detect a variety of extracellular pathogens to which cytoplasmic innate immune sensors are rarely exposed…”
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Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin by Hochheiser, Katharina, Wiede, Florian, Wagner, Teagan, Freestone, David, Enders, Matthias H, Olshansky, Moshe, Russ, Brendan, Nüssing, Simone, Bawden, Emma, Braun, Asolina, Bachem, Annabell, Gressier, Elise, McConville, Robyn, Park, Simone L, Jones, Claerwen M, Davey, Gayle M, Gyorki, David E, Tscharke, David, Parish, Ian A, Turner, Stephen, Herold, Marco J, Tiganis, Tony, Bedoui, Sammy, Gebhardt, Thomas

“…Tissue-resident memory T cells (TRM cells) are key elements of tissue immunity. Here, we investigated the role of the regulator of T cell receptor and cytokine…”
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CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity by Gressier, Elise, Schulte-Schrepping, Jonas, Petrov, Lev, Brumhard, Sophia, Stubbemann, Paula, Hiller, Anna, Obermayer, Benedikt, Spitzer, Jasper, Kostevc, Tomislav, Whitney, Paul G., Bachem, Annabell, Odainic, Alexandru, van de Sandt, Carolien, Nguyen, Thi H. O., Ashhurst, Thomas, Wilson, Kayla, Oates, Clare V. L., Gearing, Linden. J., Meischel, Tina, Hochheiser, Katharina, Greyer, Marie, Clarke, Michele, Kreutzenbeck, Maike, Gabriel, Sarah S., Kastenmüller, Wolfgang, Kurts, Christian, Londrigan, Sarah L., Kallies, Axel, Kedzierska, Katherine, Hertzog, Paul J., Latz, Eicke, Chen, Yu-Chen E., Radford, Kristen J., Chopin, Michael, Schroeder, Jan, Kurth, Florian, Gebhardt, Thomas, Sander, Leif E., Sawitzki, Birgit, Schultze, Joachim L., Schmidt, Susanne V., Bedoui, Sammy

“…Antiviral CD8 + T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for…”
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High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases by Jia, Xiaoxiao, Crawford, Jeremy Chase, Gebregzabher, Deborah, Monson, Ebony A, Mettelman, Robert C, Wan, Yanmin, Ren, Yanqin, Chou, Janet, Novak, Tanya, McQuilten, Hayley A, Clarke, Michele, Bachem, Annabell, Foo, Isabelle J, Fritzlar, Svenja, Carrera Montoya, Julio, Trenerry, Alice M, Nie, Shuai, Leeming, Michael G, Nguyen, Thi H O, Kedzierski, Lukasz, Littler, Dene R, Kueh, Andrew, Cardamone, Tina, Wong, Chinn Yi, Hensen, Luca, Cabug, Aira, Laguna, Jaime Gómez, Agrawal, Mona, Flerlage, Tim, Boyd, David F, Van de Velde, Lee-Ann, Habel, Jennifer R, Loh, Liyen, Koay, Hui-Fern, van de Sandt, Carolien E, Konstantinov, Igor E, Berzins, Stuart P, Flanagan, Katie L, Wakim, Linda M, Herold, Marco J, Green, Amanda M, Smallwood, Heather S, Rossjohn, Jamie, Thwaites, Ryan S, Chiu, Christopher, Scott, Nichollas E, Mackenzie, Jason M, Bedoui, Sammy, Reading, Patrick C, Londrigan, Sarah L, Helbig, Karla J, Randolph, Adrienne G, Thomas, Paul G, Xu, Jianqing, Wang, Zhongfang, Chua, Brendon Y, Kedzierska, Katherine

“…Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized…”
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Effective Priming of Herpes Simplex Virus-Specific CD8 + T Cells In Vivo Does Not Require Infected Dendritic Cells by Whitney, Paul G, Makhlouf, Christina, MacLeod, Beth, Ma, Joel Z, Gressier, Elise, Greyer, Marie, Hochheiser, Katharina, Bachem, Annabell, Zaid, Ali, Voehringer, David, Heath, William R, Wagle, Mayura V, Parish, Ian, Russell, Tiffany A, Smith, Stewart A, Tscharke, David C, Gebhardt, Thomas, Bedoui, Sammy

“…Resolution of virus infections depends on the priming of virus-specific CD8 T cells by dendritic cells (DC). While this process requires major…”
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