Search Results - "Bacha, P"

Pivotal Phase III Trial of Two Dose Levels of Denileukin Diftitox for the Treatment of Cutaneous T-Cell Lymphoma by OLSEN, Elise, DUVIC, Madeleine, OSEROFF, Allan, PINTER-BROWN, Lauren, BOWEN, Glen, KUZEL, Timothy, FIVENSON, David, FOSS, Francine, GLODE, Michael, MOLINA, Arturo, KNOBLER, Elizabeth, STEWART, Stanford, FRANKEL, Arthur, COOPER, Kevin, STEVENS, Seth, CRAIG, Fiona, REUBEN, James, BACHA, Patricia, NICHOLS, Jean, KIM, Youn, MARTIN, Ann, VONDERHEID, Eric, JEGASOTHY, Brian, WOOD, Gary, GORDON, Michael, HEALD, Peter

“…The objective of this phase III study was to determine the efficacy, safety, and pharmacokinetics of denileukin diftitox (DAB389IL-2, Ontak [Ligand…”
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Risk Factors and Attributable Mortality Associated with Superinfections in Neutropenic Patients with Cancer by Nucci, Marcio, Spector, Nelson, Bueno, Ana Paula, Solza, Cristiana, Perecmanis, Tatiana, Bacha, Paulo Cesar, Pulcheri, Wolmar

“…To identify the risk factors and attributable mortality associated with superinfections in febrile neutropenic patients with hematologic malignancies, we…”
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Interleukin 2 receptor-targeted cytotoxicity: interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein by BACHA, P, WILLIAMS, D. P, WATERS, C, WILLIAMS, J. M, MURPHY, J. R, STROM, T. B

“…The IL-2 toxin-mediated inhibition of protein synthesis in high affinity IL-2-R-positive murine and human T cell lines has been examined. Both excess free IL-2…”
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Data Analysis of High-Throughput Screening Results:  Application of Multidomain Clustering to the NCI Anti-HIV Data Set by Tamura, Susan Y, Bacha, Patricia A, Gruver, Heather S, Nutt, Ruth F

“…The routine use of high-throughput screening (HTS) systems in the drug discovery process has resulted in an increasing need for fast, reliable analysis of…”
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Cytotoxic properties of DAB486EGF and DAB389EGF, epidermal growth factor (EGF) receptor-targeted fusion toxins by Shaw, J.P., Akiyoshi, D.E., Arrigo, D.A., Rhoad, A.E., Sullivan, B., Thomas, J., Genbauffe, F.S., Bacha, P., Nichols, J.C.

“…Elevated expression of the receptor for epidermal growth factor (EGF) is a characteristic of several malignancies including those of the breast, bladder,…”
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Prevention of smooth muscle cell outgrowth from human atherosclerotic plaque by a recombinant cytotoxin specific for the epidermal growth factor receptor by PICKERING, J. G, BACHA, P. A, WEIR, L, JAKANOWSKI, J, NICHILS, J. C, ISNER, J. M

“…Smooth muscle cell proliferation in the intima of arteries is a principal event associated with vascular narrowing after balloon angioplasty and bypass…”
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Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein by Williams, D P, Parker, K, Bacha, P, Bishai, W, Borowski, M, Genbauffe, F, Strom, T B, Murphy, J R

“…We have genetically replaced the diphtheria toxin receptor binding domain with a synthetic gene encoding interleukin-2 (IL-2) and a translational stop signal…”
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Interleukin 2-diphtheria Toxin Fusion Protein Can Abolish Cell-Mediated Immunity in vivo by Kelley, V. E., Bacha, P., Pankewycz, O., Nichols, Jean C., Murphy, J. R., Strom, T. B.

“…De novo expression of the interleukin 2 receptor (IL-2R) is a critical and pivotal event in initiation of an immune response. Targeting the low-affinity…”
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Thyrotropin-releasing hormone-diphtheria toxin-related polypeptide conjugates. Potential role of the hydrophobic domain in toxin entry by Bacha, P, Murphy, J R, Reichlin, S

“…We have separately coupled a modified thyrotropin-releasing hormone (TRH) molecule to two diphtheria toxin-related polypeptides, CRM26 and CRM45. Both…”
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Impact of interleukin-2-receptor-targeted cytotoxins on a unique model of murine interleukin-2-receptor-expressing malignancy by Bacha, P A, Forte, S E, McCarthy, D M, Estis, L, Yamada, G, Nichols, J C

“…DAB486IL-2 is a genetically engineered fusion protein consisting of a portion of diphtheria toxin fused to human IL-2. It is specifically cytotoxic for tumor…”
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Three cases of infection with Fusarium species in neutropenic patients by NUCCI, M, SPECTOR, N, LUCENA, S, BACHA, P. C, PULCHERI, W, LAMOSA, A, DEROSSI, A, CAIUBY, M. J, MACIEIRA, J, OLIVEIRA, H. P

“…Three cases are reported of disseminated infection due to Fusarium species in severely neutropenic patients. The clinical findings in all patients included…”
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Amphotericin B followed by itraconazole in the treatment of disseminated fungal infections in neutropenic patients by Nucci, M, Pulcheri, W, Bacha, P C, Spector, N, Caiuby, M J, Costa, R O, de Oliveira, H P

“…The role of the new triazoles in the treatment of disseminated fungal infections in neutropenic patients is at present under scrutiny. Six neutropenic patients…”
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Immunotherapy of experimental autoimmune myasthenia gravis: selective effects of CTLA4Ig and synergistic combination with an IL2-Diphtheria toxin fusion protein by McIntosh, Kevin R, Linsley, Peter S, Bacha, Patricia A, Drachman, Daniel B

“…We examined the effects of CTLA4Ig treatment in an experimental model of myasthenia gravis (EAMG) induced by immunizing Lewis rats with purified Torpedo…”
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Fungal infections in neutropenic patients. A 8-year prospective study by Nucci, M, Pulcheri, W, Spector, N, Bueno, A P, Bacha, P C, Caiuby, M J, Derossi, A, Costa, R, Morais, J C, de Oliveira, H P

“…In this paper we report a eight-year prospective study designed to further characterize incidence, epidemiology, specific syndromes, treatment and prognosis…”
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Epidermal Growth Factor Receptor-Targeted Cytotoxin Inhibits Neointimal Hyperplasia In Vivo: Results of Local Versus Systemic Administration by Pastore, Christopher J, Isner, Jeffrey M, Bacha, Patricia A, Kearney, Marianne, Pickering, J. Geoffrey

“…Smooth muscle cell accumulation is a key feature of restenosis that may be inhibited by the delivery of receptortargeted cytotoxins. DAB389 EGF is a…”
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Systemic toxicity of diphtheria toxin-related fragments (CRM26, CRM45), a hormone-toxin hybrid protein (TRH-CRM45), and ricin A by Bacha, P, Reichlin, S

“…As a preliminary step in evaluating the use of thyrotropin releasing hormone (TRH) linked to toxin fragments for systemic treatment of pituitary disease, we…”
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Isolation and characterization of extragenic suppressor strains of Corynebacterium diphtheriae by Bacha, P, Murphy, J R

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Regulation of alkane oxidation in Pseudomonas putida by Grund, A, Shapiro, J, Fennewald, M, Bacha, P, Leahy, J, Markbreiter, K, Nieder, M, Toepfer, M

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Toxicity of diphtheria toxin-related proteins produced by suppression of nonsense mutations by Bacha, P, Murphy, J R, Moynihan, M

“…The Mr = 62,000 diphtheria toxin-related proteins produced from the suppression of nonsense mutations within the tox gene of corynephage beta were purified by…”
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A multicenter dose-escalation trial with denileukin diftitox (ONTAK, DAB(389)IL-2) in patients with severe psoriasis by Martin, A, Gutierrez, E, Muglia, J, McDonald, C J, Guzzo, C, Gottlieb, A, Pappert, A, Garland, W T, Bagel, J, Bacha, P

“…Denileukin diftitox, a fusion protein targeting both malignant and normal activated lymphocytes, has been shown previously to have antipsoriatic activity…”
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