Search Results - "Bach, Svitlana V."

Proteasome modulates positive and negative translational regulators in long-term synaptic plasticity by Dong, Chenghai, Bach, Svitlana V, Haynes, Kathryn A, Hegde, Ashok N

“…Proteolysis by the ubiquitin-proteasome pathway appears to have a complex role in synaptic plasticity, but its various functions remain to be elucidated. Using…”
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Integrating gene expression and imaging data across Visium capture areas with visiumStitched by Eagles, Nicholas J, Bach, Svitlana V, Tippani, Madhavi, Ravichandran, Prashanthi, Du, Yufeng, Miller, Ryan A, Hyde, Thomas M, Page, Stephanie C, Martinowich, Keri, Collado-Torres, Leonardo

“…Abstract Background Visium is a widely-used spatially-resolved transcriptomics assay available from 10x Genomics. Standard Visium capture areas (6.5mm by…”
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SUFI: an automated approach to spectral unmixing of fluorescent multiplex images captured in mouse and post-mortem human brain tissues by Sadashivaiah, Vijay, Tippani, Madhavi, Page, Stephanie C, Kwon, Sang Ho, Bach, Svitlana V, Bharadwaj, Rahul A, Hyde, Thomas M, Kleinman, Joel E, Jaffe, Andrew E, Maynard, Kristen R

“…Multispectral fluorescence imaging coupled with linear unmixing is a form of image data collection and analysis that allows for measuring multiple molecular…”
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The proteasome and epigenetics: zooming in on histone modifications by Bach Svitlana V., Hegde Ashok N.

“…The proteasome is a structural complex of many proteins that degrades substrates marked by covalent linkage to ubiquitin. Many years of research has shown a…”
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An Improved CRISPR/dCas9 Interference Tool for Neuronal Gene Suppression by Duke, Corey G., Bach, Svitlana V., Revanna, Jasmin S., Sultan, Faraz A., Southern, Nicholas T., Davis, M. Natalie, Carullo, Nancy V. N., Bauman, Allison J., Phillips, Robert A., Day, Jeremy J.

“…The expression of genetic material governs brain development, differentiation, and function, and targeted manipulation of gene expression is required to…”
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Distinct roles of Bdnf I and Bdnf IV transcript variant expression in hippocampal neurons by Bach, Svitlana V., Bauman, Allison J., Hosein, Darya, Tuscher, Jennifer J., Ianov, Lara, Greathouse, Kelsey M., Henderson, Benjamin W., Herskowitz, Jeremy H., Martinowich, Keri, Day, Jeremy J.

“…Brain‐derived neurotrophic factor (Bdnf) plays a critical role in brain development, dendritic growth, synaptic plasticity, as well as learning and memory. The…”
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A Neuron-Optimized CRISPR/dCas9 Activation System for Robust and Specific Gene Regulation by Savell, Katherine E, Bach, Svitlana V, Zipperly, Morgan E, Revanna, Jasmin S, Goska, Nicholas A, Tuscher, Jennifer J, Duke, Corey G, Sultan, Faraz A, Burke, Julia N, Williams, Derek, Ianov, Lara, Day, Jeremy J

“…CRISPR-based technology has provided new avenues to interrogate gene function, but difficulties in transgene expression in post-mitotic neurons has delayed…”
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Proteasome limits plasticity-related signaling to the nucleus in the hippocampus by Vashisht, Anirudh, Bach, Svitlana V., Fetterhoff, Dustin, Morgan, James W., McGee, Maria, Hegde, Ashok N.

“…•We studied proteasomal regulation of nuclear signaling in synaptic plasticity.•We used subthreshold long-term potentiation as our experimental model.•We…”
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Proteasome regulates transcription-favoring histone methylation, acetylation and ubiquitination in long-term synaptic plasticity by Bach, Svitlana V., Tacon, P. Ryan, Morgan, James W., Hegde, Ashok N.

“…•We studied proteasomal regulation of histone modification in synaptic plasticity.•We used chemically-induced long-term potentiation (cLTP) as our experimental…”
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Local ubiquitin-proteasome-mediated proteolysis and long-term synaptic plasticity by Hegde, Ashok N, Haynes, Kathryn A, Bach, Svitlana V, Beckelman, Brenna C

“…The ubiquitin-proteasome pathway (UPP) of protein degradation has many roles in synaptic plasticity that underlies memory. Work on both invertebrate and…”
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P3‐211: PHARMACOLOGIC INHIBITION OF LIM KINASE PROVIDES DENDRITIC SPINE RESILIENCE AGAINST AMYLOID‐β by Henderson, Benjamin W., Greathouse, Kelsey M., Bach, Svitlana V., Walker, Courtney K., Day, Jeremy J., Seyfried, Nicholas T., Herskowitz, Jeremy H.

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PHARMACOLOGIC INHIBITION OF LIM KINASE PROVIDES DENDRITIC SPINE RESILIENCE AGAINST AMYLOID-β by Henderson, Benjamin W., Greathouse, Kelsey M., Bach, Svitlana V., Walker, Courtney K., Day, Jeremy J., Seyfried, Nicholas T., Herskowitz, Jeremy H.

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Proteasome regulates transcription and translation in long-term synaptic plasticity by Bach, Svitlana V

“…Long-term synaptic plasticity, which underlies long-term memory, depends on new gene transcription, new protein synthesis, as well as proteolytic degradation…”
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The proteasome and epigenetics: zooming in on histone modifications by Bach, Svitlana V, Hegde, Ashok N

“…The proteasome is a structural complex of many proteins that degrades substrates marked by covalent linkage to ubiquitin. Many years of research has shown a…”
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