Search Results - "Bach, Mark A."

754-P: A First-in-Human Single Ascending Dose Study of GSBR-1290, a Novel Small Molecule GLP-1 Receptor Agonist, in Healthy Volunteers by COLL, BLAI, ZHANG, JINQIANG J., JACOBER, SCOTT J., ARGENT, CHRISTOPHER, IBARRA, LANI, SNYDER, MARGO, BACH, MARK A.

“…Introduction: Type 2 Diabetes Mellitus (T2DM) and obesity incidences are rising globally. The risk:benefit ratio of peptide GLP-1 receptor agonists (RAs) has…”
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Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults : A Randomized Trial by NASS, Ralf, PEZZOLI, Suzan S, BLACKMAN, Marc R, CLANCY OLIVERI, Mary, PATRIE, James T, HARRELL, Frank E, CLASEY, Jody L, HEYMSFIELD, Steven B, BACH, Mark A, LEE VANCE, Mary, THORNER, Michael O

“…Growth hormone secretion and muscle mass decline from midpuberty throughout life, culminating in sarcopenia, frailty, decreased function, and loss of…”
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Dissecting the Workforce and Workplace for Clinical Endocrinology, and the Work of Endocrinologists Early in Their Careers by Desjardins, Claude, Bach, Mark A, Cappola, Anne R, Seely, Ellen W, Ehrenberg, Ronald G

“…The results provide an evidenced-based framework for improving the investigative workforce for clinical endocrinology. Context: The United States lacks timely…”
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Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia by Wessells, Hunter, Roy, Johnny, Bannow, John, Grayhack, John, Matsumoto, Alvin M, Tenover, Lisa, Herlihy, Richard, Fitch, William, Labasky, Richard, Auerbach, Stephen, Parra, Raul, Rajfer, Jacob, Culbertson, Jennifer, Lee, Michael, Bach, Mark A, Waldstreicher, Joanne

“…To evaluate the incidence and resolution of sexual adverse experiences (AEs) in men with benign prostatic hyperplasia treated with finasteride 5 mg compared…”
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The Effects of MK-0677, an Oral Growth Hormone Secretagogue, in Patients with Hip Fracture by Bach, Mark A., Rockwood, Kenneth, Zetterberg, Carl, Thamsborg, Gorm, Hébert, Réjean, Devogelaer, Jean-Pierre, Christiansen, Jens Sandahl, Rizzoli, René, Ochsner, J.Lockwood, Beisaw, Norman, Gluck, Oscar, Yu, Leisure, Schwab, Thomas, Farrington, Jeanne, Taylor, Alice M., Ng, Jennifer, Fuh, Vivian

“…Objectives: To evaluate the effects of MK‐0677, an orally active growth hormone (GH) secretagogue, on functional recovery from hip fracture in previously…”
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Are Performance-Based Measures Sufficiently Reliable for Use in Multicenter Trials? by Jette, Alan M., Jette, Diane U., Ng, Jennifer, Plotkin, Diane J., Bach, Mark A.

“…Background. The literature contains few reports of the test-retest reliability of performance-based measures. The purpose of this study was to determine the…”
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767-P: A Phase 1b/2a Study of the Safety and Tolerability of GSBR-1290, a Novel Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist (GLP-1RA), in Healthy Overweight/Obese Volunteers (HOV) and Participants with Type 2 Diabetes Mellitus (T2DM) by Coll, Blai, Zhang, Jinqiang, Chen, Libo, Ibarra, Lani, Yue, Huibin, Barth, Aline, Bach, Mark A

“…Introduction: GSBR-1290 is a novel, oral, non-peptide GLP-1RA and a potential alternative to injectable or oral peptides used for the treatment of T2DM and…”
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THE ENDOCRINE SOCIETY ETHICS ADVISORY COMMITTEE: Ethical Aspects of Conflicts of Interests, October 2003 by Komesaroff, Paul A, Bach, Mark A, Danoff, Ann, Grumbach, Melvin M, Kaplan, Selna, Lakoski, Joan M, Leitman, Dale, Mellon, Synthia, Underwood, Louis E, Leupen, Sarah

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Peptidomimetic Growth Hormone Secretagogues. Design Considerations and Therapeutic Potential by Nargund, Ravi P, Patchett, Arthur A, Bach, Mark A, Murphy, M. Gail, Smith, Roy G

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Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brain by Bach, M A, Shen-Orr, Z, Lowe, Jr, W L, Roberts, Jr, C T, LeRoith, D

“…The expression of mRNAs encoding insulin-like growth factor I (IGF-I) and the IGF-I receptor in the developing rat brain from embryonic day 16 to postnatal day…”
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Growth hormone releasing peptides: growth studies by Bach, Mark A, Cambria, Marnie

“…Although recombinant human growth hormone (GH) remains the gold standard for treatment of GH-deficient (GHD) children, growth hormone releasing hormone is also…”
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Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects by CHAPMAN, I. M, BACH, M. A, HARTMAN, M. L, VELDHUIS, J. D, GORMLEY, G. J, THORNER, M. O, VAN CAUTER, E, FARMER, M, KRUPA, D, TAYLOR, A. M, SCHILLING, L. M, COLE, K. Y, SKILES, E. H, PEZZOLI, S. S

“…Aging is associated with declining activity of the GH axis, possibly contributing to adverse body composition changes and increased incidence of cardiovascular…”
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Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults: A Randomized, Controlled Trial by Nass, Ralf, Pezzoli, Suzan S., Oliveri, Mary Clancy, Patrie, James T., Harrell, Frank E., Clasey, Jody L., Heymsfield, Steven B., Bach, Mark A., Lee Vance, Mary, Thorner, Michael O.

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Clinical uses of insulin-like growth factor I by Bondy, C A, Underwood, L E, Clemmons, D R, Guler, H P, Bach, M A, Skarulis, M

“…Insulin-like growth factor I (IGF-I) has acute insulin-like metabolic effects and long-term anabolic actions. The therapeutic potential of recombinant human…”
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The effects of subcutaneous insulin-like growth factor-I infusion in insulin-dependent diabetes mellitus by Bach, M A, Chin, E, Bondy, C A

“…Insulin-dependent diabetes can be associated with low insulin-like growth factor-I (IGF-I) levels despite normal or even high GH secretion. The basis of the…”
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Anatomy of the pituitary insulin-like growth factor system by Bach, M A, Bondy, C A

“…In situ hybridization was used to map patterns of gene expression for components of the insulin-like growth factor (IGF) system, including IGF-I and -II,…”
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Structural and functional analysis of the insulin-like growth factor I receptor gene promoter by Werner, H, Bach, M A, Stannard, B, Roberts, Jr, C T, LeRoith, D

“…The insulin-like growth factor I receptor (IGF-I-R) gene is expressed in most body tissues. The levels of IGF-I-R mRNA, however, are regulated by a number of…”
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Repeated pressure-flow studies in the evaluation of bladder outlet obstruction due to benign prostatic enlargement by Tammela, Teuvo L.J., Schäfer, Werner, Barrett, David M., Abrams, Paul, Hedlund, Hans, Rollema, Harm J., Matos-Ferreira, A., Nordling, J., Bruskewitz, R., Miller, Paul, Kirby, Roger, Andersen, Jens T., Jacobsen, Carol, Gormley, Glenn J., Malice, Marie-Pierre, Bach, Mark A.

“…Test‐retest reliability of repeated voids in pressure‐flow studies and the influence on maximum flow rate (QmaxpQ), detrusor pressure at maximum flow rate…”
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Are Performance-Based Measures Sufficiently Reliable for Use in Multicenter Trials? by Jette, Alan M, Jette, Diane U, Ng, Jennifer, Plotkin, Diane J, Bach, Mark A, The Musculoskeletal Impairment (MSI) Study Group

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Continued improvement in pressure-flow parameters in men receiving finasteride for 2 years by Schäfer, W., Tammela, T.L.J., Barrett, D.M., Abrams, P., Hedlund, H., Rollema, H.J., Nordling, J., Andersen, J.T., Hald, T., Matos-Ferriera, A., Bruskewitz, R., Miller, P., Mustonen, S., Cannon, A., Malice, Marie-Pierre, Jacobsen, Carol A., Bach, Mark A.

“…Objectives. To assess the long-term effects of finasteride on pressure-flow parameters in men with urodynamically documented bladder outflow obstruction (BOO)…”
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