Search Results - "Baccanari, D. P"

Peptide Agonist of the Thrombopoietin Receptor as Potent as the Natural Cytokine by Cwirla, Steven E., Balasubramanian, Palaniappan, Duffin, David J., Wagstrom, Christopher R., Gates, Christian M., Singer, Sara C., Davis, Ann M., Tansik, Robert L., Mattheakis, Larry C., Boytos, Chris M., Schatz, Peter J., Baccanari, David P., Wrighton, Nicholas C., Barrett, Ronald W., Dower, William J.

“…Two families of small peptides that bind to the human thrombopoietin receptor and compete with the binding of the natural ligand thrombopoietin (TPO) were…”
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5-Ethynyluracil (776C85): A Potent Modulator of the Pharmacokinetics and Antitumor Efficacy of 5-Fluorouracil by Baccanari, David P., Davis, Stephen T., Knick, Vincent C., Spector, Thomas

“…5-Ethynyluracil (5-EU, 776C85) is a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (EC 1.3.1.2), the rate-determining enzyme in…”
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X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase:  High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH Is Displaced by an Inhibitor by WHITLOW, Marc, HOWARD, Andrew J., STEWART, David, HARDMAN, Karl D., CHAN, Joseph H., BACCANARI, David P., TANSIK, Robert L., HONG, Jean S., KUYPER, Lee F.

“…X-ray crystallographic analysis of 5-(4'-substituted phenyl)sulfanyl-2,4-diaminoquinazoline inhibitors in ternary complex with Candida albicans dihydrofolate…”
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α-Fluoro-β-alanine: Effects on the antitumor activity and toxicity of 5-fluorouracil by Cao, Shousong, Baccanari, David P, Rustum, Youcef M, Davis, Stephen T, Tansik, Robert L, Porter, David J.T, Spector, Thomas

“…We have shown previously that ( R)-5-fluoro-5,6-dihydrouracil (FUraH 2) attenuates the antitumor activity of 5-fluorouracil (FUra) in rats bearing advanced…”
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Dihydropyrimidine dehydrogenase inactivation and 5-fluorouracil pharmacokinetics : allometric scaling of animal data, pharmacokinetics and toxicodynamics of 5-fluorouracil in humans by SOO PEANG KHOR, AMYX, H, DAVIS, S. T, NELSON, D, BACCANARI, D. P, SPECTOR, T

“…The pharmacokinetics of 5-fluorouracil (5-FU) in different animal species treated with the dihydropyrimidine dehydrogenase (DPD) inactivator, 5-ethynyluracil…”
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Basis of selectivity of antibacterial diaminopyrimidines by Baccanari, D P, Kuyper, L F

“…The basis for the high affinity and selectivity of trimethoprim [2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine, TMP] and several close structural…”
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5-Ethynyluracil (776C85): protection from 5-fluorouracil-induced neurotoxicity in dogs by Davis, S T, Joyner, S S, Baccanari, D P, Spector, T

“…5-Ethynyluracil (776C85) is a potent mechanism-based inactivator of dihydropyrimidine dehydrogenase (DPD), the enzyme that catalyzes the rapid catabolism of…”
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5-Ethynyluracil (77C85) : effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil by SHOUSONG CAO, BACCANARI, D. P, JOYNER, S. S, DAVIS, S. T, RUSTUM, Y. M, SPECTOR, T

“…We studied the effects of 5-ethynyluracil (776C85 and 776C), a potent mechanism-based inactivator of dihydropyrimidine dehydrogenase, on the antitumor efficacy…”
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Characterization of Candida albicans Dihydrofolate Reductase by Baccanari, D P, Tansik, R L, Joyner, S S, Fling, M E, Smith, P L, Freisheim, J H

“…Dihydrofolate reductase from Candida albicans was purified 31,000-fold and characterized. In addition, the C. albicans dihydrofolate reductase gene was cloned…”
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Crystal structure of a novel trimethoprim-resistant dihydrofolate reductase specified in Escherichia coli by R-plasmid R67 by Matthews, David A, Smith, S. L, Baccanari, D. P, Burchall, J. J, Oatley, S. J, Kraut, J

“…Crystalline R67 dihydrofolate reductase (DHFR) is a dimeric molecule with two identical 78 amino acid subunits, each folded into a beta-barrel conformation…”
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Inhibition of Uridine Phosphorylase. Synthesis and Structure−Activity Relationships of Aryl-Substituted 1-((2-Hydroxyethoxy)methyl)-5-(3-phenoxybenzyl)uracil by Orr, G. Faye, Musso, David L, Kelley, James L, Joyner, Suzanne S, Davis, Stephen T, Baccanari, David P

“…Structure−activity relationship studies on a series of 1-((2-hydroxyethoxy)methyl)-5-(3-(substituted-phenoxy)benzyl)uracils as inhibitors of murine liver…”
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Effect of a single amino acid substitution on Escherichia coli dihydrofolate reductase catalysis and ligand binding by Baccanari, D P, Stone, D, Kuyper, L

“…The two isozymes of dihydrofolate reductase (Forms 1 and 2) from, a Trimethoprim-resistant strain of Escherichia coli (RT500) were separated and purified to…”
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Inhibition of uridine phosphorylase: synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils by Orr, G. Faye, Musso, David L, Boswell, G. Evan, Kelley, James L, Joyner, Suzanne S, Davis, Stephen T, Baccanari, David P

“…A series of 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils were synthesized and tested for inhibition of murine liver uridine phosphorylase (UrdPase). Inhibitors…”
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Characterization of an R-plasmid dihydrofolate reductase with a monomeric structure by Joyner, S S, Fling, M E, Stone, D, Baccanari, D P

“…A plasmid-encoded dihydrofolate reductase that originated in a clinical isolate of Salmonella typhimurium (phage type 179) moderately resistant to trimethoprim…”
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2,4-Diamino-5-benzylpyrimidines and analogs as antibacterial agents. 9. Lipophilic trimethoprim analogs as antigonococcal agents by Roth, B, Baccanari, D. P, Sigel, C. W, Hubbell, J. P, Eaddy, J, Kao, J. C, Grace, M. E, Rauckman, B. S

“…Lipophilic analogues of trimethoprim (1) bearing 3,5-dialkyl-4-hydroxy substituents in the benzene ring are much more active in vitro against Neisseria…”
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Species-dependent differences in the biochemical effects and metabolism of 5-benzylacyclouridine by Davis, S T, Joyner, S S, Chandrasurin, P, Baccanari, D P

“…The pharmacokinetics and biochemical effects of the uridine phosphorylase (UrdPase) inhibitor 5-benzylacyclouridine (BAU) were investigated in the mouse, rat…”
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Characterization and amino acid sequence of Neisseria gonorrhoeae dihydrofolate reductase by BACCANARI, D. P, TANSIK, R. L, PATERSON, S. J, STONE, D

“…Dihydrofolate reductase has been purified from a trimethoprim-resistant strain of Neisseria gonorrhoeae. The enzyme showed a single component on sodium dodecyl…”
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Refolding of recombinant Pneumocystis carinii dihydrofolate reductase and characterization of the enzyme by Delves, C J, Ballantine, S P, Tansik, R L, Baccanari, D P, Stammers, D K

“…The isolation of dihydrofolate reductase (DHFR) cDNA sequences from the messenger RNA of Pneumocystis carinii using the polymerase chain reaction is described…”
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R plasmid dihydrofolate reductase with subunit structure by Smith, S L, Stone, D, Novak, P, Baccanari, D P, Burchall, J J

“…Dihydrofolate reductase, specified by the type II plasmid of a trimethoprim-resistant Escherichia coli, was purified 40-fold to homogeneity using a combination…”
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Selective Inhibitors of Candida albicans Dihydrofolate Reductase: Activity and Selectivity of 5-(Arylthio)-2,4-diaminoquinazolines by Chan, Joseph H, Hong, Jean S, Kuyper, Lee F, Baccanari, David P, Joyner, Suzanne S, Tansik, Robert L, Boytos, Christine M, Rudolph, Sharon K

“…The recent increase in fungal infections, especially among AIDS patients, has resulted in the need for more effective antifungal agents. In our search for such…”
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